Nucl Med Mol Imaging.  2016 Sep;50(3):185-195. 10.1007/s13139-016-0397-x.

Radiolabeled Phosphonium Salts as Mitochondrial Voltage Sensors for Positron Emission Tomography Myocardial Imaging Agents

• Kim DY
• Min JJ

• KMID: 2351642
• DOI: http://doi.org/10.1007/s13139-016-0397-x

Abstract

Despite substantial advances in the diagnosis of cardiovascular disease, ¹â¸F-labeled positron emission tomography (PET) radiopharmaceuticals remain necessary to diagnose heart disease because clinical use of current PET tracers is limited by their short half-life. Lipophilic cations such as phosphonium salts penetrate the mitochondrial membranes and accumulate in mitochondria of cardiomyocytes in response to negative inner-transmembrane potentials. Radiolabeled tetraphenylphosphonium cation derivatives have been developed as myocardial imaging agents for PET. In this review, a general overview of these radiotracers, including their radiosynthesis, in vivo characterization, and evaluation is provided and clinical perspectives are discussed.

Keyword

¹⁸F-Fluoroalkylphosphonium cations; Mitochondrial voltage sensors; Myocardial imaging agents; Positron emission tomography; Tetraphenylphosphonium cation derivatives

MeSH Terms

Cardiovascular Diseases
Cations
Diagnosis
Electrons*
Half-Life
Heart Diseases
Mitochondria
Mitochondrial Membranes
Myocytes, Cardiac
Positron-Emission Tomography*
Radiopharmaceuticals
Salts*
Cations
Radiopharmaceuticals
Salts