Nucl Med Mol Imaging.  2018 Aug;52(4):266-278. 10.1007/s13139-018-0521-1.

Emerging Tracers for Nuclear Cardiac PET Imaging

• Kim DY
• Cho SG
• Bom HS

• KMID: 2418990
• DOI: http://doi.org/10.1007/s13139-018-0521-1

Abstract

Myocardial perfusion imaging using positron emission tomography (PET) has several advantages over single photon emission computed tomography (SPECT). The recent advances in SPECT technology have shown promise, but there is still a large need for PET in the clinical management of coronary artery disease (CAD). Especially, absolute quantification of myocardial blood flow (MBF) using PET is extremely important. In spite of considerable advances in the diagnosis of CAD, novel PET radiopharmaceuticals remain necessary for the diagnosis of CAD because clinical use of current cardiac radiotracers is limited by their physical characteristics, such as decay mode, emission energy, and half-life. Thus, the use of a radioisotope that has proper characteristics and a proper half-life to develop myocardial perfusion agents could overcome these limitations. In this review, the current state of cardiac PET and a general overview of novel ¹â¸F or ⁶⁸Ga-labeled radiotracers, including their radiosynthesis, in vivo characterization, and evaluation, are provided. The future perspectives are discussed in terms of their potential usefulness based on new image analysis methods and hybrid imaging.

Keyword

Coronary artery disease(CAD); Myocardialimagingagents; ¹⁸F-labeledmitochondrialvoltage sensors; ⁶⁸Ga-labeled cardiac imaging agents; Positron emission tomography

MeSH Terms

Coronary Artery Disease
Diagnosis
Half-Life
Myocardial Perfusion Imaging
Perfusion
Positron-Emission Tomography
Radiopharmaceuticals
Tomography, Emission-Computed, Single-Photon
Radiopharmaceuticals