Nucl Med Mol Imaging.  2019 Dec;53(6):382-385. 10.1007/s13139-019-00620-y.

Perspectives in TSPO PET Imaging for Neurologic Diseases

• Song YS

• KMID: 2469581
• DOI: http://doi.org/10.1007/s13139-019-00620-y

Abstract

The translocator protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein, which has brought attention as a neuroinflammatory biomarker. Positron emission tomography (PET) imaging studies have been done for several decades, since neuroinflammation has been implicated as an important pathophysiology of several common neurologic disorders. However, despite numerous previous studies with positive findings, its clinical significance is not yet clear. Various attempts to overcome the limitations are ongoing, in order to bring acceptance for use in clinics.

Keyword

Neuroinflammation; Neurologic disease; Positron emission tomography; Translocator protein (18 kDa)

MeSH Terms

Nervous System Diseases
Positron-Emission Tomography