- Morphological studies on pancreas and kidney in cyclophosphamide-induced NOD mice
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Seong JK, Oh YS
- KMID: 1700044
- J Korean Diabetes Assoc.
- 1993 Mar;17(1):59-72.
No abstract available. -
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- Inhibition of diabetes in non-obese diabetic mice by nicotinamide treatment for 5 weeks at the early age
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Kim JY, Chi JK, Kim EJ, Park SY, Kim YW, Lee SK
- KMID: 1081049
- J Korean Med Sci.
- 1997 Aug;12(4):293-297.
- doi: 10.3346/jkms.1997.12.4.293
To know the effects of nicotinamide (NCT) treatment for 5 weeks at the early age on insulitis and development of diabetes in non-obese diabetic (NOD) mice, this experiment was... -
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- Defects in the differentiation and function of bone marrow-derived dendritic cells in non-obese diabetic mice
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Lee M, Kim AY, Kang Y
- KMID: 648127
- J Korean Med Sci.
- 2000 Apr;15(2):217-223.
- doi: 10.3346/jkms.2000.15.2.217
Due to their high immunostimulatory ability as well as the critical role they play in the maintenance of self-tolerance, dendritic cells have been implicated in the pathogenesis of autoimmune diseases.... -
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- Prevention of overt diabetes and insulitis by BCG administration in the NOD mice of the breast-fed period
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Hwang TS, Kang HS, Kim YU
- KMID: 2092714
- Korean J Anat.
- 2000 Feb;33(1):49-54.
By the concept that IDDM (insulin-dependent diabetes mellitus) is one of the autoimmune diseases, several immune suppressive drugs and immune modulators including BCG have been used to suppress the occurrence... -
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- Effects of BCG, lymphotoxin and bee venom on insulitis and development of IDDM in non-obese diabetic mice
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Kim JY, Cho SH, Kim YW, Jang EC, Park SY, Kim EJ, Lee SK
- KMID: 646041
- J Korean Med Sci.
- 1999 Dec;14(6):648-652.
- doi: 10.3346/jkms.1999.14.6.648
To investigate whether BCG, lymphtoxin (LT) or bee venom (BV) can prevent insulitis and development of diabetes in non-obese diabetic (NOD) mice, we measured the degree of insulitis and incidence... -
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- Toll-like receptor 4 on islet beta cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes
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Li M, Song L, Gao X, Chang W, Qin X
- KMID: 1365903
- Exp Mol Med.
- 2012 Apr;44(4):260-267.
- doi: 10.3858/emm.2012.44.4.021
Type 1 diabetes mellitus is caused by the autoimmune destruction of beta cells within the islets. In recent years, innate immunity has been proposed to play a key role in... -
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- Effect of Mouse Type and Human Type of CpG Oligonucleotide Vaccination on Development of Diabetes in NOD Mice
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Lee BJ, Kim SK, Park ES, Jang HJ, Cho HC, Shim MS, Kim MJ, Shin YG, Chung CH
- KMID: 2008287
- J Korean Diabetes Assoc.
- 2002 Dec;26(6):451-459.
BACKGROUND: Type 1 diabetes is autoimmune disease and the modulation of immune system could offer breakthrough to the disease. Unmethylated CpG motifs and their oligoneucleotide are potent immunostimulators that can... -
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- Distinct Pattern of GAD65 and GAD67 Gene Expression in the Pancreas of NOD Mouse
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Ko IY, Kang Y
- KMID: 2137369
- J Korean Diabetes Assoc.
- 1997 Sep;21(3):243-253.
BACKGROUND: Glutamic acid decarboxylase(GAD; EC 4.1.1.15), one of the major B-cell autoantigens in IDDM, is an enzyme which catalyzes the synthesis of major inhibitory neurotransmitter, r-aminobutyric acid (GARA), in the... -
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- Polymeric Gene Delivery for Diabetic Treatment
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Kim SW
- KMID: 2281637
- Diabetes Metab J.
- 2011 Aug;35(4):317-326.
- doi: 10.4093/dmj.2011.35.4.317
Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene... -
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- IL-10 Plasmid DNA Delivery in NOD Mice for the Prevention of Autoimmune Pancreatic Beta Cell Destruction
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Koh JJ, Ko KS, Park JS, Kim WB, Park KS, Kim SY, Lee HK, Shin SG, Kim SW
- KMID: 2199619
- J Korean Soc Endocrinol.
- 2000 Jun;15(2):262-271.
BACKGROUND: Recently, we have reported that biodegradable poly [-(4-aminobutyl)-L-glycolic acid] (PAGA) can condense and protect plasmid DNA from DNase I. In this study, we investigated whether the systemic administration of... -
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- Limited Effect of CpG ODN in Preventing Type 1 Diabetes in NOD Mice
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Lee BJ, Kim SK, Kim MK, Park ES, Cho HC, Shim MS, Kim MJ, Shin YG, Chung CH
- KMID: 1734067
- Yonsei Med J.
- 2005 Jun;46(3):341-346.
- doi: 10.3349/ymj.2005.46.3.341
Type 1 diabetes is considered as Th1 cell mediated autoimmune disease and the suppression of Th1 cells or the activation of Th2 cells has been regarded as a plausible immunologic... -
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- Spontaneous osteosarcoma of the femur in a non-obese diabetic mouse
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Hong S, Lee HA, Choe O, Chung Y, Kim O
- KMID: 1850053
- Lab Anim Res.
- 2011 Sep;27(3):251-254.
- doi: 10.5625/lar.2011.27.3.251
An abnormal swelling was identified in the distal portion of the right femur in a 1-year-old non-obese diabetic (NOD) mouse. Grossly, a large mass of the distal femur was observed... -
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- Short-Term High Expression of Interferon-Alpha Modulates Progression of Type 1 Diabetes in NOD Mice
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Park MK, Seo SY, Hong SH, Kim HJ, Park EJ, Kim DK, Lee HJ
- KMID: 1512940
- Korean J Physiol Pharmacol.
- 2006 Feb;10(1):39-44.
Type I diabetes (T1D) is an organ-specific autoimmune disease caused by the T cell-mediated destruction of the insulin-producing beta cells in the pancreatic islets. The onset of T1D is the... -
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- Cotransplanted Bone Marrow Derived Mesenchymal Stem Cells (MSC) Enhanced Engraftment of Hematopoietic Stem Cells in a MSC-dose Dependent Manner in NOD/SCID Mice
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Kim DH, Yoo KH, Yim YS, Choi J, Lee SH, Jung HL, Sung KW, Yang SE, Oh WI, Yang YS, Kim SH, Choi SY, Koo HH
- KMID: 1713108
- J Korean Med Sci.
- 2006 Dec;21(6):1000-1004.
- doi: 10.3346/jkms.2006.21.6.1000
Transplantation of marrow-derived mesenchymal stem cells (MSCs), expanded by culture in addition to whole bone marrow, has been shown to enhance engraftment of human hematopoietic stem cells (HSCs). Our hypothesis... -
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- Co-transplantation of Human Mesenchymal Stem Cells Promotes Human CD34+ Cells Engraftment in a Dose-dependent Fashion in NOD/SCID Mice
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Park SK, Won JH, Kim HJ, Bae SB, Kim CK, Lee KT, Lee NS, Lee YK, Jeong DC, Chung NG, Kim HS, Hong DS, Park HS
- KMID: 1778346
- J Korean Med Sci.
- 2007 Jun;22(3):412-419.
- doi: 10.3346/jkms.2007.22.3.412
Mesenchymal stem cells (MSCs) have recently been identified and characterized in humans. Moreover, MSC secrete cytokines that can support hematopoietic progenitor growth. In the present study, we evaluated whether the... -
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- The efficacy of SPA0355 in protecting beta cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes
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Bae UJ, Song MY, Jang HY, Gim HJ, Ryu JH, Lee SM, Jeon R, Park BH
- KMID: 2154270
- Exp Mol Med.
- 2013 Nov;45(11):e51.
Cytokines activate several inflammatory signals that mediate beta-cell destruction. We recently determined that SPA0355 is a strong anti-inflammatory compound, thus reporting its efficacy in protecting beta cells from various insults.... -
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- Effect of Human Parathyroid Hormone on Hematopoietic Progenitor Cells in NOD/SCID Mice Co-Transplanted with Human Cord Blood Mononuclear Cells and Mesenchymal Stem Cells
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Lim YJ, Hwang K, Kim M, Cho YH, Lee JH, Lee YH, Seo JJ
- KMID: 1776945
- Yonsei Med J.
- 2013 Jan;54(1):238-245.
- doi: 10.3349/ymj.2013.54.1.238
PURPOSE: We evaluated the effect of human parathyroid hormone (hPTH) on the engraftment and/or in vivo expansion of hematopoietic stem cells in an umbilical cord blood (UCB)-xenotransplantation model. In addition,... -
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- Establishment of a canine mammary gland tumor cell line and characterization of its miRNA expression
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Osaki T, Sunden Y, Sugiyama A, Azuma K, Murahata Y, Tsuka T, Ito N, Imagawa T, Okamoto Y
- KMID: 2413139
- J Vet Sci.
- 2016 Sep;17(3):385-390.
- doi: 10.4142/jvs.2016.17.3.385
Canine mammary gland tumors (CMGTs), which are the most common neoplasms in sexually intact female dogs, have been suggested as a model for studying human breast cancer because of several... -
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- Peptide/Gene Therapy for the Prevention of Diabetes
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Park Y
- KMID: 2168168
- Hanyang Med Rev.
- 2009 May;29(2):176-185.
Pancreatic betacell function deteriorates continuously in type 2 diabetes patients despite optimal treatment, which has been attributed to hyperglycemia itself via formation of excess reactive oxygen species. Studies of animals... -
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- Apoptosis of Human Islet Cells by Cytokines
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Kim S, Kim KA, Suk K, Kim YH, Oh SH, Lee MK, Kim KW, Lee MS
- KMID: 2168009
- Immune Netw.
- 2012 Jun;12(3):113-117.
- doi: 10.4110/in.2012.12.3.113
FasL, perforin, TNFalpha, IL-1 and NO have been considered as effector molecule(s) leading to beta-cell death in autoimmune diabetes. However, the real culprit(s) of beta-cell destruction have long been elusive... -
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