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Bioprospecting Potential of the Soil Metagenome: Novel Enzymes and Bioactivities

Lee MH, Lee SW

The microbial diversity in soil ecosystems is higher than in any other microbial ecosystem. The majority of soil microorganisms has not been characterized, because the dominant members have not been...
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Journal Walk Regarding the Expanding Role of Microbiota in Our Gut

Kang JS

No abstract available.
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Microflora Modulation of Motility

Quigley EM

  • KMID: 2326207
  • J Neurogastroenterol Motil.
  • 2011 Apr;17(2):140-147.
That gastrointestinal motility can influence the gut microbiota has been known for decades and the clinical consequences of impaired motility, in terms of the bacterial population of the small intestine,...
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Statistical Analysis of Metagenomics Data

Calle ML

Understanding the role of the microbiome in human health and how it can be modulated is becoming increasingly relevant for preventive medicine and for the medical management of chronic diseases....
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Inflammasomes in antiviral immunity: clues for influenza vaccine development

Yamazaki T, Ichinohe T

Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and...
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Metagenome Analysis of Bodily Microbiota in a Mouse Model of Alzheimer Disease Using Bacteria-derived Membrane Vesicles in Blood

Park JY, Choi J, Lee Y, Lee JE, Lee EH, Kwon HJ, Yang J, Jeong BR, Kim YK, Han PL

Emerging evidence has suggested that the gut microbiota contribute to brain dysfunction, including pathological symptoms of Alzheimer disease (AD). Microbiota secrete membrane vesicles, also called extracellular vesicles (EVs), which contain...
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Dysbiosis of the Faecal Microbiota in Patients with Crohn's Disease and Their Unaffected Relatives (Gut 2011;60:631-637)

Kang SJ, Im JP

No abstract available.
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Human Resistome Study with Metagenomic Sequencing Data

Shin JH, Rho M

With the introduction of synthetic antibiotics, many lives including humans and animals have been saved against bacterial infection. An increasing level of antibiotics use, however, raises serious problems of multi-drug...
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Current Status and Future Promise of the Human Microbiome

Kim BS, Jeon YS, Chun J

  • KMID: 2315410
  • Pediatr Gastroenterol Hepatol Nutr.
  • 2013 Jun;16(2):71-79.
The human-associated microbiota is diverse, varies between individuals and body sites, and is important in human health. Microbes in human body play an essential role in immunity, health, and disease....
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Analysis of Oropharyngeal Microbiota between the Patients with Bronchial Asthma and the Non-Asthmatic Persons

Dang HT, Kim SA, Park HK, Shin JW, Park SG, Kim W

Bronchial asthma can be triggered by microbial agents in the oropharynx. This study was designed to identify the differences in microbiota of oropharynx of bronchial asthmatic patients in contrast to...
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Oral and Human Microbiome Research

Chung SK

In the past gut microbiome has been the main focus of microbiome research. Studies about the microbiome inside oral cavities and other organs are underway. Studies about the relationship between...
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Rapid Assessment of Microbiota Changes in Individuals with Autism Spectrum Disorder Using Bacteria-derived Membrane Vesicles in Urine

Lee Y, Park JY, Lee EH, Yang J, Jeong BR, Kim YK, Seoh JY, Lee S, Han PL, Kim EJ

Individuals with autism spectrum disorder (ASD) have altered gut microbiota, which appears to regulate ASD symptoms via gut microbiota-brain interactions. Rapid assessment of gut microbiota profiles in ASD individuals in...
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Oral Metagenomic Analysis Techniques

Chung SK

The modern era of microbial genome analysis began in earnest in the 2000s with the generalization of metagenomics and gene sequencing techniques. Studying complex microbial community such as oral cavity...
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Comparative Analysis of Ileal and Cecal Microbiota in Aged Rats

Lee SM, Kim N, Park JH, Nam RH, Yoon K, Lee DH

BACKGROUND: Gut microbiota contributes to intestinal and immune homeostasis through host-microbiota interactions. Distribution of the gut microbiota differs according to the location in the gastrointestinal tract. Although the microbiota properties...
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Comparison of differences in microbial compositions between negative controls and subject samples with varying analysis configurations

Kim H, Lee SP, Kang SM, Kang SY, Jung S, Lee SM

PURPOSE: Identifying microbial communities with 16S ribosomal RNA (rRNA) gene sequencing is a popular approach in microbiome studies, and various software tools and data resources have been developed for microbial...
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Pathogenesis of Inflammatory Bowel Diseases

Nagahori M, Nemoto Y, Watanabe M

Our understanding of IBD pathogenesis has been increasing rapidly. The genetically determined interplay between the commensal microbiota, intestinal epithelial cells, and the immune system has been appreciated deeply. The interplay...
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Gut Microbiota and Clinical Disease: Obesity and Nonalcoholic Fatty Liver Disease

Park JS, Seo JH, Youn HS

The prevalence of obesity is increasing worldwide. Obesity can cause hyperlipidemia, hypertension, cardiovascular diseases, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Many environmental or genetic factors have been suggested...
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Gut Microbiota in Inflammatory Bowel Disease

Shim JO

The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesis of inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along...
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Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant

Park YM, Lee SY, Kang MJ, Kim BS, Lee MJ, Jung SS, Yoon JS, Cho HJ, Lee E, Yang SI, Seo JH, Kim HB, Suh DI, Shin YH, Kim KW, Ahn K, Hong SJ

PURPOSE: The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and...
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Application of Metagenomic Techniques: Understanding the Unrevealed Human Microbiota and Explaining the in Clinical Infectious Diseases

Kim W

Uncultured microorganisms comprise the majority of the planet's biological diversity. In many environments, as many as 99% of the microorganisms cannot be cultured by standard techniques, and the uncultured fraction...
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