Pediatr Gastroenterol Hepatol Nutr.  2013 Mar;16(1):22-27. 10.5223/pghn.2013.16.1.22.

Gut Microbiota and Clinical Disease: Obesity and Nonalcoholic Fatty Liver Disease

• Park JS
• Seo JH
• Youn HS

• KMID: 1428803
• DOI: http://doi.org/10.5223/pghn.2013.16.1.22

Abstract

The prevalence of obesity is increasing worldwide. Obesity can cause hyperlipidemia, hypertension, cardiovascular diseases, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Many environmental or genetic factors have been suggested to contribute to the development of obesity, but there is no satisfactory explanation for its increased prevalence. This review discusses the latest updates on the role of the gut microbiota in obesity and NAFLD.

Keyword

Obesity; Microbiota; Non-alcoholic fatty liver disease

MeSH Terms

Cardiovascular Diseases
Fatty Liver
Hyperlipidemias
Hypertension
Metagenome
Obesity
Prevalence
Fatty Liver

Figure

• 

  Fig. 1 Schematic view of the possible mechanisms linking gut microbiota to obesity and nonalcoholic metabolic liver disease. Adapted from Tsukumo et al. Arq Bras Endocrinol Metabol 2009;53:139-44 [44].

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