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Acute Leukemia Relapse Presenting as Recurrent Involvement of the Optic Nerve

Lee SY, Yoon JH, Chung SA

PURPOSE: To report two cases with recurrent involvement of the optic nerve as the initial sign of acute leukemic relapse. CASE SUMMARY: An 8-year-old male with acute lymphoblastic leukemia on the...
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Two Cases of Cytomegalovirus Infection Developed in Pediatric Acute Lymphoblastic Leukemia Patients

Jung N, Kim D, Chin HS, Kim SK

A 14 year-old boy with acute lymphoblastic leukemia (ALL) on maintenance chemotherapy presented with vision-threatening cytomegalovirus (CMV) retinitis. Treatment with intavitreal ganciclovir injection (2 mg/0.1 mL) followed by oral ganciclovir...
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Pemetrexed Continuation Maintenance versus Conventional Platinum-Based Doublet Chemotherapy in EGFR-Negative Lung Adenocarcinoma: Retrospective Analysis

Paik SS, Hwang IK, Park MJ, Lee SH

BACKGROUND: Although targeted therapy and immuno-oncology have shifted the treatment paradigm for lung cancer, platinum-based combination is still the standard of care for advanced non-small cell lung cancer (NSCLC). Pemetrexed...
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The Role of Consolidation Chemoradiotherapy in Locally Advanced Pancreatic Cancer Receiving Chemotherapy: An Updated Systematic Review and Meta-Analysis

Chang JS, Chiu YF, Yu JC, Chen LT, Ch'ang HJ

PURPOSE: The role of consolidation chemoradiation (CCRT) after systemic chemotherapy in locally advanced pancreatic cancer (LAPC) is still controversial. We aim to evaluate the effectiveness of CCRT in LAPC using...
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Severe recurrent nocturnal hypoglycemia during chemotherapy with 6-mercaptopurine in a child with acute lymphoblastic leukemia

Cho EM, Moon JE, Lee SJ, Ko CW

Various endocrine dysfunctions occur during chemotherapy, including hypoglycemia. However, reports of hypoglycemia associated with 6-mercaptopurine (6-MP) are rare. Herein, we report an 8-year-old boy with severe symptomatic hypoglycemia likely due...
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Physical, Psychological and Social Symptoms, Activity and Education of Children and Adolescents with Acute Lymphoblastic Leukemia Receiving Maintenance Chemotherapy

Yoon HS, Kim KS, Choi SH, Choi SE, Kim KA, Kim KE

PURPOSE: This study was to identify the physical, psychological and social symptoms of ALL (acute lymphoblastic leukemia) children and adolescents receiving maintenance chemotherapy to build a basic data set to...
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Long Term Complete Response of Unresectable Locally Advanced Pancreatic Cancer after CCRT and Gemcitabine Chemotherapy

Yang J, Lim T, Kim T, Han S, Lee S, Kim H, Lee J, Ahn S

Locally advanced or metastatic disease accounts for two thirds of total patients with pancreatic cancer. Patients with pancreatic cancer are assessed as resectable, potentially resectable (borderline) or unresectable according to...
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Pemetrexed Continuation Maintenance in Patients with Nonsquamous Non-small Cell Lung Cancer: Review of Two East Asian Trials in Reference to PARAMOUNT

Yang JC, Ahn MJ, Nakagawa K, Tamura T, Barraclough H, Enatsu S, Cheng R, Orlando M

PURPOSE: A recent phase III study (PARAMOUNT) demonstrated that pemetrexed continuation maintenance therapy is a new treatment paradigm for advanced nonsquamous non-small cell lung cancer (NSCLC). The majority of patients...
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Prognostic Value of Splenic Artery Invasion in Patients Undergoing Adjuvant Chemoradiotherapy after Distal Pancreatectomy for Pancreatic Adenocarcinoma

Kim BH, Kim K, Chie EK, Jang JY, Kim SW, Han SW, Oh DY, Im SA, Kim TY, Bang YJ, Joo I, Ha SW

PURPOSE: The purpose of this study was to evaluate the outcome of adjuvant chemoradiotherapy (CRT) after distal pancreatectomy (DP) in patients with pancreatic adenocarcinoma, and to identify the prognostic factors...
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Insertion of Totally Implantable Central Venous Access Devices by Surgeons

An H, Ryu CG, Jung EJ, Kang HJ, Paik JH, Yang JH, Hwang DY

PURPOSE: The aim of this study is to evaluate the results for the insertion of totally implantable central venous access devices (TICVADs) by surgeons. METHODS: Total 397 patients, in whom TICVADs...
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Oral Maintenance Chemotherapy with 6-Mercaptopurine and Methotrexate in Patients with Acute Myeloid Leukemia Ineligible for Transplantation

Choi YW, Jeong SH, Ahn MS, Lee HW, Kang SY, Choi JH, Park JS

For decades, maintenance chemotherapy has failed to improve the cure rate or prolong the survival of patients with acute myeloid leukemia (AML), other than those with acute promyelocytic leukemia. Immediately...
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Cytotoxic Chemotherapy for Non-small Cell Lung Cancer

Park BB

Non-small-cell lung cancer is one of the leading causes of deaths from cancer worldwide. There have been remarkable advances in the targeted treatment of advanced non-small cell lung cancer (NSCLC)...
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Update on the Evidence Regarding Maintenance Therapy

Lee JE, Chung CU

  • KMID: 2320482
  • Tuberc Respir Dis.
  • 2014 Jan;76(1):1-7.
Maintenance therapy has emerged as a novel therapeutic paradigm for advanced non-small-cell lung cancer (NSCLC). Maintenance therapy that aims to sustain a clinically favorable state after first-line chemotherapy has two...
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A feasibility study on maintenance of docetaxel after paclitaxel-carboplatin chemotherapy in patients with advanced ovarian cancer

Isonishi S, Suzuki M, Nagano H, Takagi K, Shimauchi , Kawabata M, Ochiai K

OBJECTIVE: To test the concept of taxane sequencing, this feasibility trial evaluated maintenance of docetaxel after paclitaxel and carboplatin combination chemotherapy in patients with stage IC-IV ovarian cancer. METHODS: All patients...
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Clinical Prognostic Factors for Locally Advanced Esophageal Squamous Carcinoma Treated after Definitive Chemoradiotherapy

Kim DE, Kim UJ, Choi WY, Kim MY, Kim SH, Kim MJ, Shim HJ, Hwang JE, Bae WK, Chung IJ, Nam TK, Na KJ, Cho SH

  • KMID: 2167638
  • Cancer Res Treat.
  • 2013 Dec;45(4):276-284.
PURPOSE: Locally advanced esophageal cancers are generally treated with neoadjuvant chemoradiotherapy, followed by surgery in operable candidates. However, even if the patients were diagnosed as operable disease, surgery could not...
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Second Complete Remission of Relapsed Stage IV Non-Small Cell Lung Cancer Following Retreatment

Yoo SJ, Lee JE, Jung SY, Park DI, Park MR, Park HS, Jung SS, Kim JO, Kim SY

  • KMID: 2319811
  • Tuberc Respir Dis.
  • 2012 Apr;72(4):381-385.
Non-small cell lung cancer (NSCLC) is the leading cause of cancer related deaths. Most patients were presented with advanced disease at the time of diagnosis. In advanced NSCLC, it is...
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Parvovirus B19 Infection in a Child with Acute Lymphoblastic Leukemia during Maintenance Chemotherapy

Sung KW, Chang EJ, Jang WJ, Jeon IS

  • KMID: 1441722
  • Clin Pediatr Hematol Oncol.
  • 2012 Apr;19(1):44-48.
Parvovirus B19 targets human erythroid progenitor cells, causing a self-limiting subclinical erythroid aplasia in the healthy hosts, whereas the immunocompromised subjects generate a prolonged viremia and chronic anemia with or...
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Fatal Broncho-Mediastinal Fistula in a Patient with Non-Small Cell Lung Cancer after Photodynamic Therapy

Heo EY, Kim YJ, Yang SC

Photodynamic therapy (PDT) can be used as palliative therapy to reduce obstructive symptoms in patients with advanced lung cancer. Herein, we report on the case of a patient with fatal...
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Staphylococcal Endocarditis Presenting with a Renal Infarct in a Patient with Acute Lymphoblastic Leukemia

Son MH, Park ES, Seo JH, Lim JY, Park CH, Woo HO, Youn HS

  • KMID: 1804618
  • Cancer Res Treat.
  • 2008 Sep;40(3):151-154.
We present here a patient with acute lymphoblastic leukemia (ALL) and who developed infective endocarditis during induction chemotherapy with prednisolone, L-asparaginase (Leunase(R)), vincristine and adriamycin. The patient did not have...
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Genetic Polymorphism of Thiopurine Methyltransferase in Children with Acute Lymphoblastic Leukemia

Cho HG, Baek HJ, Han DK, Bae SY, Kook H, Hwang TJ

  • KMID: 1483074
  • Clin Pediatr Hematol Oncol.
  • 2008 Apr;15(1):1-9.
Purpose: 6-mercaptopurine (6-MP) is a very important drug in pediatric patients for the maintenance treatment of acute lymphoblastic leukemia (ALL). 6-MP is catabolized by thiopurine methyltransferase (TPMT). TPMT activity, one...
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