Clin Pediatr Hematol Oncol.
2019 Oct;26(2):115-118. 10.15264/cpho.2019.26.2.115.
Two Cases of Cytomegalovirus Infection Developed in Pediatric Acute Lymphoblastic Leukemia Patients
- Affiliations
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- 1Department of Pediatrics, Inha University Hospital, Incheon, Korea. pedkim@inha.ac.kr
- 2Department of Ophthalmology, Inha University Hospital, Incheon, Korea.
- KMID: 2464261
- DOI: http://doi.org/10.15264/cpho.2019.26.2.115
Abstract
- A 14 year-old boy with acute lymphoblastic leukemia (ALL) on maintenance chemotherapy presented with vision-threatening cytomegalovirus (CMV) retinitis. Treatment with intavitreal ganciclovir injection (2 mg/0.1 mL) followed by oral ganciclovir resulted in successful resolution of CMV retinitis. Another 13 year-old boy with ALL on maintenance chemotherapy presented with prolonged fever with no response to antibiotics administration. CMV and real-time PCR revealed positive result and a titer of 2,618,700 copies/mL, respectively. Ganciclovir was used for more than the approved duration of treatment, but viral titer frequently recurred with elevated liver enzymes and fever. In these 2 cases of CMV infection, a high index of suspicion and prompt management is important in children receiving ALL chemotherapy.
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