Clin Pediatr Hematol Oncol.  2019 Oct;26(2):115-118. 10.15264/cpho.2019.26.2.115.

Two Cases of Cytomegalovirus Infection Developed in Pediatric Acute Lymphoblastic Leukemia Patients

Affiliations
  • 1Department of Pediatrics, Inha University Hospital, Incheon, Korea. pedkim@inha.ac.kr
  • 2Department of Ophthalmology, Inha University Hospital, Incheon, Korea.

Abstract

A 14 year-old boy with acute lymphoblastic leukemia (ALL) on maintenance chemotherapy presented with vision-threatening cytomegalovirus (CMV) retinitis. Treatment with intavitreal ganciclovir injection (2 mg/0.1 mL) followed by oral ganciclovir resulted in successful resolution of CMV retinitis. Another 13 year-old boy with ALL on maintenance chemotherapy presented with prolonged fever with no response to antibiotics administration. CMV and real-time PCR revealed positive result and a titer of 2,618,700 copies/mL, respectively. Ganciclovir was used for more than the approved duration of treatment, but viral titer frequently recurred with elevated liver enzymes and fever. In these 2 cases of CMV infection, a high index of suspicion and prompt management is important in children receiving ALL chemotherapy.

Keyword

Cytomegalovirus; Acute lymphoblastic leukemia

MeSH Terms

Anti-Bacterial Agents
Child
Cytomegalovirus Infections*
Cytomegalovirus*
Drug Therapy
Fever
Ganciclovir
Humans
Liver
Maintenance Chemotherapy
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Real-Time Polymerase Chain Reaction
Retinitis
Anti-Bacterial Agents
Ganciclovir
Full Text Links
  • CPHO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error