Korean J Gastroenterol.
2000 Jan;35(1):1-8.
Effects and Prognostic Factors of Combined Chemotherapy and Radiotherapy in Treatment of Patients with Esophageal Cancer
Abstract
- BACKGROUND/AIMS
The prognosis of esophageal cancer has been exceedingly poor. Recently, many studies demonstrated that combined chemotherapy and radiotherapy improved the survival. In this study, we analyzed remission rate, survival rate, recurrance rate, and prognostic factors of the esophageal cancer retrospectively.
METHODS
Twenty-six patients with esophageal cancer who received chemotherapy with radiotherapy were included in this study. Radiotherapy was undertaken with 180 cGy per day upto 6500 cGy. All patients received two cylces of chemotherapy and the additional 2-4 cycles of maintenance chemotherapy (cisplatin 75 mg/m2 IV on the first day and 5-FU 1,000 mg/m2 for four days) after radiotherapy.
RESULTS
For the 26 patients, overall response rate was 61.6%. One year and 2 year survival rate was 66.1% and 41.7%, respectively and median survival was 89 weeks. Recurrence rate was 42.3%. The observed toxicity of this combined modality were nausea in 76.9%, leukopenia in 61.5%, mucositis in 53.9%, pneumonia in 21.3%, and esophageal stenosis in 23.1% of the patients. CONCLUSIONS: This combined modality improved the response rate and median survival. Additionally, clinical stage, performance status and the response to treatment were identified as important prognostic factors.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Analysis of Treatment in the Patients with Non-Hodgkin's Lymphoma of the Head and Neck
- Combined-modality Therapy for Locoregional Esophageal Cancer
- Treatment Results and Prognostic Factors in Localized Gastrointestinal Non-Hodgkin's Lymphoma
- Treatment of Esophageal Cancer
- The Results of Combined External Radiotherapy and Chemotherapyin the Management of Esophageal Cancer
