- Definition, Pathogenesis, and Natural Progress of Non-alcoholic Fatty Liver Disease
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Jeon JH, Park KG
- KMID: 2173896
- J Korean Diabetes.
- 2014 Jun;15(2):65-70.
- doi: 10.4093/jkd.2014.15.2.65
Non-alcoholic fatty liver disease (NAFLD) is emerging as a world-wide health problem and is currently recognized as a hepatic manifestation of metabolic syndrome. It is an umbrella term to describe... -
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- Intercellular Lipid Mediators and GPCR Drug Discovery
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Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
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- Lipidomic analysis of plasma lipids composition changes in septic mice
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Ahn WG, Jung JS, Song DK
- KMID: 2414264
- Korean J Physiol Pharmacol.
- 2018 Jul;22(4):399-408.
- doi: 10.4196/kjpp.2018.22.4.399
A lipidomic study on extensive plasma lipids in bacterial peritonitis (cecal ligation and puncture, CLP)-induced sepsis in mice was done at 24 h post-CLP. The effects of administration of lysophosphatidylcholine... -
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- Lysophosphatidylcholine suppresses apoptosis and induces neurite outgrowth in PC12 cells through activation of phospholipase D2
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Yun DH, Jeon ES, Sung SM, Ryu SH, Kim JH
- KMID: 1110121
- Exp Mol Med.
- 2006 Aug;38(4):375-384.
Lysophosphatidylcholine (LPC) is a bioactive lipid generated by phospholipase A2-mediated hydrolysis of phosphatidylcholine. In the present study, we demonstrate that LPC stimulates phospholipase D2 (PLD2) activity in rat pheochromocytoma PC12... -
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- Lysophosphatidylcholine, Oxidized Low-Density Lipoprotein and Cardiovascular Disease in Korean Hemodialysis Patients: Analysis at 5 Years of Follow-up
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Lee YK, Lee DH, Kim JK, Park MJ, Yan JJ, Song DK, Vaziri ND, Noh JW
- KMID: 1429196
- J Korean Med Sci.
- 2013 Feb;28(2):268-273.
- doi: 10.3346/jkms.2013.28.2.268
Although oxidized low-density lipoprotein (LDL) and lysophosphatidylcholine (LPC) have been proposed as important mediators of the atherosclerosis, the long-term contribution to the risk of cardiovascular disease (CVD) in hemodialysis patients... -
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- The Effect of Naringin on the Lysophosphatidylcholine-induced Proliferation of Vascular Smooth Muscle Cells
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Kim SH, Kim IW, Lee HY, Chae IH, Kim MA, Kim HS, Kim CH, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Lee YW
- KMID: 1643996
- Korean Circ J.
- 2002 Jan;32(1):61-70.
- doi: 10.4070/kcj.2002.32.1.61
BACKGROUND AND OBJECTIVES: Lysophosphatidylcholine (lysoPC), an atherogenic lysophospholipid, is known to induce the proliferation of vascular smooth muscle cells (VSMCs). Naringin is a flavonoid in grapes and grapefruits and has... -
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- Increase of Intracellular Ca2+ Concentration Induced by Lysophosphatidylcholine in Murine Aortic Endothelial Cells
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Zhu MH, Park SJ, Kim HJ, Yang DK, Suh SH, So I, Kim KW
- KMID: 1614997
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):93-100.
Effects of oxidized low-density lipoprotein (ox-LDL), l-alpha-stearoyl-lysophosphatidylcholine (LPC), on intracellular Ca2+ concentration were examined in mouse endothelial cells by measuring intracellular Ca2+ concentration ([Ca2+]i) with fura 2-AM and reverse transcription-polymerase... -
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- Cytotoxic Effects of Lysophosphatidylcholine on Vascular Smooth Muscle Cells
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Lee DY, Kang YH, Choi DS, Lee YJ, Rhyu MR, Yoon BK
- KMID: 2321326
- J Korean Soc Menopause.
- 2012 Dec;18(3):139-146.
OBJECTIVES: To investigate the cytotoxic effects of lysophosphatidylcholine (lysoPC), an active component of oxidized low-density lipoproteins (LDL), on vascular smooth muscle cells (VSMCs). METHODS: VSMCs were derived from rat aorta. Cell... -
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- Lysophosphatidylcholine Attenuates Endothelium-dependent Relaxation Responses through Inhibition of ACh-induced Endothelial [Ca2+]i Increase
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Kwon SC, Lee YH, Nam T, Ahn DS
- KMID: 1512938
- Korean J Physiol Pharmacol.
- 2006 Feb;10(1):25-30.
Lysophosphatidylcholine (LPC), which accumulates in atherosclerotic arteries, has been reported to inhibit endothelium-dependent relaxation (EDR) in many different species. However, the underlying mechanism of LPC-induced inhibition of EDR is still... -
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- Bioactive Lysophosphatidylcholine 16:0 and 18:0 Are Elevated in Lungs of Asthmatic Subjects
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Yoder M, Zhuge Y, Yuan Y, Holian O, Kuo S, van Breemen R, Thomas LL, Lum H
- KMID: 2166937
- Allergy Asthma Immunol Res.
- 2014 Jan;6(1):61-65.
- doi: 10.4168/aair.2014.6.1.61
PURPOSE: Asthma is a chronic inflammatory disease of the airways, and is associated with upregulation of phospholipase A2 (PLA2), the enzyme that hydrolyzes phosphatidylcholine, producing lysophosphatidylcholine (LPC) and free fatty... -
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- Targeted Plasma Metabolite Profiling of Metformin in Healthy Korean Volunteers
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Lihm HS, Cha J, Seo JJ, Park J, Lee J, Lee HW, Bae KS, Kim W, Yoon YR
- KMID: 2334537
- J Korean Soc Clin Pharmacol Ther.
- 2012 Dec;20(2):175-181.
BACKGROUND: Metformin is an effective oral antihyperglycaemic agent for type 2 diabetes mellitus, with a variety of metabolic effects. In addition to controlling blood glucose level, it has been appeared... -
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- Association of the vascular endothelial damage and estrogen, progesterone
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Kim MK, Kim JA, Jeon YJ, Park JS, Park MH, Suh SH, Chun SH, Ahn JJ, Kim YJ
- KMID: 1870353
- Korean J Obstet Gynecol.
- 2007 Mar;50(3):429-438.
OBJECTIVE: The aim of this study were to examine the serum level of estradiol, estriol, progesterone, oxidized LDL in preeclamtic patients and to evaluate the protective effects of estrogen and... -
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- Lysophosphatidylcholine Increases Ca2+ Current via Activation of Protein Kinase C in Rabbit Portal Vein Smooth Muscle Cells
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Jung S, Lee Y, Han S, Kim Y, Nam T, Ahn D
- KMID: 2071643
- Korean J Physiol Pharmacol.
- 2008 Feb;12(1):31-35.
- doi: 10.4196/kjpp.2008.12.1.31
Lysophosphatidylcholine (LPC), a metabolite of membrane phospholipids by phospholipase A(2), has been considered responsible for the development of abnormal vascular reactivity during atherosclerosis. Ca2+ influx was shown to be augmented... -
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- Effect of lysophosphatidylcholine on whole cell K+ current in rabbit coronary smooth muscle cells.
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Yi CH, Ha MY, Ahn DS, Kang BS
- KMID: 1858588
- Korean Circ J.
- 2001 Feb;31(2):217-229.
- doi: 10.4070/kcj.2001.31.2.217
BACKGROUND: Impairment of relaxing response and augmentation of contractile response to vasoactive substances have been reported in atherosclerotic arteries. These alterations in vascular reactivity are considered as an underlying mechanism... -
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- Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective
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Sidorov E, Sanghera D, Vanamala J
- KMID: 2438648
- J Stroke.
- 2019 Jan;21(1):31-41.
- doi: 10.5853/jos.2018.03454
Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find... -
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- Impact of Lysophosphatidylcholine on the Plasminogen Activator System in Cultured Vascular Smooth Muscle Cells
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Yoon BK, Kang YH, Oh WJ, Park K, Lee DY, Choi D, Kim DK, Lee Y, Rhyu MR
- KMID: 2157928
- J Korean Med Sci.
- 2012 Jul;27(7):803-810.
- doi: 10.3346/jkms.2012.27.7.803
The balance between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis. PAI-1 expression increases in atherosclerotic arteries and vascular smooth muscle cells (VSMCs) are one... -
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- Oxidized Low-density Lipoprotein- and Lysophosphatidylcholine-induced Ca2+ Mobilization in Human Endothelial Cells
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Kim MY, Liang GH, Kim JA, Choi SS, Choi S, Suh SH
- KMID: 2285368
- Korean J Physiol Pharmacol.
- 2009 Feb;13(1):27-32.
- doi: 10.4196/kjpp.2009.13.1.27
The effects of oxidized low-density lipoprotein (OxLDL) and its major lipid constituent lysophosphatidylcholine (LPC) on Ca2+ entry were investigated in cultured human umbilical endothelial cells (HUVECs) using fura-2 fluorescence and... -
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- Profiling of Serum Metabolites Using MALDI-TOF and Triple-TOF Mass Spectrometry to Develop a Screen for Ovarian Cancer
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Lee JH, Kim YH, Kim KH, Cho JY, Woo SM, Yoo BC, Kim SC
- KMID: 2417877
- Cancer Res Treat.
- 2018 Jul;50(3):883-893.
- doi: 10.4143/crt.2017.275
PURPOSE: We sought to develop a matrix assisted laser desorption ionization-time of flight (MALDI-TOF)-based, ovarian cancer (OVC), low-mass-ion discriminant equation (LOME) and to evaluate a possible supportive role for triple-TOF... -
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- Effect of Salicylate on the Monocyte Chemoattractant Protein-1 Expression and Intracellular Reactive Oxygen Species Formation in Human Mesangial Cells
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Chung SJ, Kim CS, Chang JW, Kim SB, Lee SK, Park JS
- KMID: 1610145
- Korean J Nephrol.
- 2003 May;22(3):261-272.
BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) and reactive oxygen species (ROS) play an important role during glomerular inflammation. We investigated the effect of aspirin metabolite, salicylate on the pro-inflammatory cytokine-induced MCP-1... -
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- Influences of Free Fatty Acids on Transmembrane Action Potential and ATP-sensitive Potassium Channel Activity in Rat Myocardium
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Kim JH, Ju JM, Park J, Baik YH, Kook H, Jeong HS, Jeong MH, Cho JG, Park JC, Kang JC
- KMID: 2093795
- Korean Circ J.
- 2000 Dec;30(12):1589-1589.
- doi: 10.4070/kcj.2000.30.12.1589
BACKGROUND: To evaluate the role of free fatty acids on the ischemic myocardium, influences of various free fatty acids upon transmembrane action potential and ATP-sensitive K+(KATP) channel activity were examined... -
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