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Immunological abnormalities in patient with IgA nephropathy

Ihm CG, Woo JT, Chang YW, Kwon OS, Kim MJ

T cell immunity and phagocytic activity were studied in the blood of patients with IgA nephropathy in order to clarify their roles in the pathogenesis of IgA nephropathy. The percentages...
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Immunology of Hepatitis C: Clinical Significance of T Cell Response

Shin EC

  • KMID: 760641
  • Korean J Hepatol.
  • 2006 Jun;12(2):140-153.
Hepatitis C virus (HCV) infection is a worldwide problem in terms of public health. It causes chronic hepatitis C in 60-80% of patients after acute hepatitis C. Chronic hepatitis C...
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Maintenance of CD8+T-cell anergy by CD4+CD25+ regulatory T cells in chronic graft-versus-host disease

Kim J, Kim HJ, Choi WS, Nam SH, Cho HR, Kwon B

  • KMID: 1098083
  • Exp Mol Med.
  • 2006 Oct;38(5):494-501.
In a murine model of systemic lupus erythematosus (SLE)-like chronic graft-versus-host disease (cGVHD), donor CD8+T cells rapidly fall into anergy to host cells, while donor CD4+T cells hyperactivate B cells...
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Studies on Lymphocyte Subpopulations and Cell-mediated lmmunity in Patients with Chronic Renal Failure

Park K, Ha SK, Han DS

Several parameters of cell-mediated immunity thirty-eight patients with end stage chronic renal failure were measured including total lymphyocytes, B-and T-lymphocytes, T-cell subsets and the mitogenic reponse to PHA and Con...
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Regulatory T Cells - An Emerging Role in Transplantation

Feng G, Wood K

No abstract available.
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Gamma/delta T lymphocytes in the BCG granulomatous lesions

Kim DS, Lee KY, Yang WI, Han SJ, Hwang EH

Recent studies in man and animal models have demonstrated that TCR-gamma delta-bearing T cells (gamma delta T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection....
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In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1

La S, Kim E, Kwon B

  • KMID: 1056231
  • Exp Mol Med.
  • 2005 Jun;37(3):193-198.
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive...
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CD99 activates T cells via a costimulatory function that promotes raft association of TCR complex and tyrosine phosphorylation of TCR zeta

Oh KI, Kim BK, Ban YL, Choi EY, Jung KC, Lee IS, Park SH

  • KMID: 1094658
  • Exp Mol Med.
  • 2007 Apr;39(2):176-184.
We investigated the co-stimulatory role of a cell-surface protein, CD99. Co-ligation of CD99 and suboptimal CD3 induced T-cell activation to a level comparable to that obtained with optimal CD3 or...
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Role of murine Peyer's patch lymphocytes against primary and challenge infections with Cryptosporidium parvum

Guk SM, Chai JY

In order to determine the role of Peyer's patch lymphocytes (PPL) in self-clearing of Cryptosporidium parvum infection in murine models, changes in PPL subsets, their cytokine expression, and in vitro...
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Antibody Response of Mouse Splenocytes Using Mixture of Supernatants of Thymocytes, Adherent and Non-adherent Splenocytes: In-vitro Immunization-II

Kim D, Noh GW, Kim DH, Kwon OH

We adapted one of the in-vitro immunization methods to induce antibody responses and confirmed the success of the immunization by enzyme-linked immunosorbent assay (ELISA) without hybridization. We have previously reported...
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The presence of CD8+ invariant NKT cells in mice

Lee H, Hong C, Shin J, Oh S, Jung S, Park YK, Hong S, Lee GR, Park SH

Invariant natural killer T (iNKT) cells develop in the thymus upon recognition of CD1d expressed on developing thymocytes. Although CD4 and CD8 coreceptors are not directly involved in the interaction...
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Analysis of the immunologic mechanism of intravesical bacillus Calmette-Guerin therapy for superficial bladder tumors: distribution and function of immune cells

Chung JY, Lee ES, Lee WJ, Kim HH, Min KJ, Lee CW

Intravesical bacillus Calmette-Guerin (BCG) administration has been used as an adjuvant therapy after transurethral resection for superficial bladder cancer, but the exact mechanisms of its antitumor activity are not yet...
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Suppression of CD4+ T-Cells in the Spleen of Mice Infected with Toxoplasma gondii KI-1 Tachyzoites

Kim WH, Shin EH, Kim JL, Yu SY, Jung BK, Chai JY

Toxoplasma gondii KI-1, a recent new isolate from Korea, shows similar pathogenicity and infectivity to mice compared to the virulent RH strain. To understand characteristics of host immunity, including immune...
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Fulminant Epstein-Barr Virus-associated T-cell Lymphoproliferative Disorder in an Immunocompetent Middle-aged Man Presenting with Chronic Diarrhea and Gastrointestinal Bleeding

Abdul-Ghafar J, Kim JW, Park KH, Cho MY

The World Health Organization (WHO) recently defined systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disorders (LPD) of childhood as a life-threatening illness. However, this rare disease has not been extensively studied....
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Decreased CD5+ B cells during the acute phase of Kawasaki disease

Kim HS, Noh GW, Kim DS, Lee KY, Lee HS, Lee HK, Lee SI

We investigated the changes of CD5+ B cells in the peripheral blood of 20 Kawasaki disease (KD) patients. The percentage of CD5+ B cells in the total lymphocytes and in...
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Expression of Hepatitis C Virus Core Protein in Hepatocytes Does Not Modulate Proliferation or Apoptosis of CD8+ T Cells

Jin YH, Crispe IN, Park S

  • KMID: 2428300
  • Yonsei Med J.
  • 2005 Dec;46(6):827-834.
Hepatocytes are the primary targets of the hepatitis C virus (HCV). While immunosuppressive roles of HCV core protein have been found in several studies, it remains uncertain whether core protein...
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T Cell-specific Immunosuppression Using Tautomycetin or PTD-conjugated Protein Drugs

Chae WJ, Choi JM, Yang JJ, Lee SK

No abstract available.
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B-cell Complement Dependent Cytotoxic Crossmatch Positivity is an Independent Risk Factor for Long-term Renal Allograft Survival

Hwang HS, Yoon HE, Choi BS, Oh EJ, Kim JI, Moon IS, Kim YS, Yang CW

The clinical significance of positive B-cell complement-dependent cytotoxicity crossmatching (B-CDC) in renal transplant recipients remains unclear. We reviewed 20 recipients with isolated B-CDC positivity at the time of transplantation. We...
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Clinical Significance of Monitoring Circulating CD4+CD25+ Regulatory T Cells in Kidney Transplantation during the Early Posttransplant Period

Kim SH, Oh EJ, Ghee JY, Song HK, Han DH, Yoon HE, Choi BS, Yoon SK, Choi JY, Moon IS, Kim DG, Yang CW

The CD4+CD25+ T regulatory cells (Tregs) play an important role in immune tolerance in experimental transplantation but the clinical significance of circulating Tregs in the peripheral blood is undetermined. In...
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Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen

Chang BS, Bohach GA, Lee SU, Davis WC, Fox LK, Ferens WA, Seo KS, Koo HC, Kwon NH, Park YH

  • KMID: 1091208
  • J Vet Sci.
  • 2005 Sep;6(3):247-250.
Our recent study has provided that the in vitro SEC-induced proliferation of bovine T cells is preceded by a period of a non-proliferative immunoregulation of T cells that may be...
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