Yonsei Med J.  1988 Jun;29(2):109-116. 10.3349/ymj.1988.29.2.109.

Studies on Lymphocyte Subpopulations and Cell-mediated lmmunity in Patients with Chronic Renal Failure

• Park K
• Ha SK
• Han DS

• KMID: 1119198
• DOI: http://doi.org/10.3349/ymj.1988.29.2.109

Abstract

Several parameters of cell-mediated immunity thirty-eight patients with end stage chronic renal failure were measured including total lymphyocytes, B-and T-lymphocytes, T-cell subsets and the mitogenic reponse to PHA and Con A at three different times; before dialysis, 3 months and 12 months after dialysis treatment. There were no significant differences in the absolute numbers of peripheral leukocytes between each patient and the control group. But the absolute numbers of lymphocytes of each patient group were significantly reduced compared to the control group (p< 0.01). The proportion of peripheral blood active T cells and helper T cells was significantly reduced both in the predialysis uremic and dialysis populations compared to the control group, although the helper/suppressor(OKT4/OKT8) ratio was not different between each patient and the control group except for a lower ratio in the hemodialysis 12 month follow-up group (HD 12M). With respect m the PHA and Con A stimulation tests, the stimulation indices of the predialysis and hemodialysis groups were significantly lower than those of the control group. However, patients on continuous ambulatory peritoneal dialysis (CAPD) exhibited a normal mitogenic response and a lower suppressor cell removal index compared to the patients on hemodialysis, suggesting an improved cell-mediated immunity in the patients undergoing CAPD.

Keyword

Uremia; lymphocyte subset; mitogenic response; hemodialysis; continuous ambulatory peritoneal dialysis (CAPD)

MeSH Terms

Adult
Aged
B-Lymphocytes/*immunology
Comparative Study
Human
In Vitro
Kidney Failure, Chronic/*immunology/therapy
Lectins/pharmacology
Leukocyte Count
Lymphocyte Activation/drug effects
Middle Age
Peritoneal Dialysis, Continuous Ambulatory
Renal Dialysis
Support, Non-U.S. Gov't
T-Lymphocytes/classification/*immunology
T-Lymphocytes, Helper-Inducer/immunology
T-Lymphocytes, Suppressor-Effector/immunology