Exp Mol Med.
2006 Oct;38(5):494-501.
Maintenance of CD8+T-cell anergy by CD4+CD25+ regulatory T cells in chronic graft-versus-host disease
- Affiliations
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- 1The Immunomodulation Research Center, University of Ulsan, Ulsan, Korea. bkwon@mail.ulsan.ac.kr
- 2Department of Biological Science, University of Ulsan, Ulsan, Korea.
- 3Department of Surgery, Ulsan University Hospital, University of Ulsan, Ulsan, Korea.
- 4Department of Biological Science, Ajou University, Suwon, Korea.
Abstract
- In a murine model of systemic lupus erythematosus (SLE)-like chronic graft-versus-host disease (cGVHD), donor CD8+T cells rapidly fall into anergy to host cells, while donor CD4+T cells hyperactivate B cells and break B-cell tolerance to self-Ags in the recipient mouse. The functional recovery of donor CD8+T cells can result in the conversion of cGVHD to acute GVHD (aGVHD), indicating that donor CD8+T-cell anergy is a restriction factor in the development of cGVHD. In this report, we present evidence that donor CD4+CD25+regulatory T cells (T(reg) cells) are critical in maintaining the donor CD8+T-cell anergy and thus suppressing the development of aGVHD in mice that are naturally prone to cGVHD. Our results provide a novel insight into the role of T(reg) cells in determining cGVHD versus aGVHD.
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