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Intervention with costimulatory pathways as a therapeutic approach for graft-versus-host disease

Kwon B

Graft-versus-host disease (GVHD) is mediated by mature donor T cells contained in the hematopoietic stem cell graft. During the development of GVHD, signaling through a variety of costimulatory receptors plays...
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Maintenance of CD8+T-cell anergy by CD4+CD25+ regulatory T cells in chronic graft-versus-host disease

Kim J, Kim HJ, Choi WS, Nam SH, Cho HR, Kwon B

  • KMID: 1098083
  • Exp Mol Med.
  • 2006 Oct;38(5):494-501.
In a murine model of systemic lupus erythematosus (SLE)-like chronic graft-versus-host disease (cGVHD), donor CD8+T cells rapidly fall into anergy to host cells, while donor CD4+T cells hyperactivate B cells...
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