- Anticholinesterase and Anti-inflammatory Constituents from Beilschmiedia pulverulenta Kosterm
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Salleh WM, Ahmad F, Yen KH, Zulkifli R
- KMID: 2366688
- Nat Prod Sci.
- 2016 Dec;22(4):225-230.
- doi: 10.20307/nps.2016.22.4.225
Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol... -
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- Comparative Study of Concentration of Isoflavones and Lignans in Plasma and Prostatic Tissues of Normal Control and Benign Prostatic Hyperplasia
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Hong SJ, Kim SI, Kwon SM, Lee JR, Chung BC
- KMID: 1118973
- Yonsei Med J.
- 2002 Apr;43(2):236-241.
- doi: 10.3349/ymj.2002.43.2.236
Objective: Isoflavones and lignans are phytoestrogens that have recently gained interest as dietary factors related to prostatic diseases. However, no data on the concentrations in prostate tissue in humans is... -
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- Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai
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Hong CE, Lyu SY
- KMID: 2317846
- Toxicol Res.
- 2013 Dec;29(4):279-283.
Acanthopanax koreanum Nakai, a well known traditional herb grown in Jeju Island, South of Korea, has been used as a tonic and sedative agent, as well as in the treatment... -
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- Chemical Constituents from Buddleja officinalis and Their Inhibitory Effects on Nitric Oxide Production
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Park TW, Lee C, Lee JW, Jang H, Jin Q, Lee MK, Hwang BY
- KMID: 2328879
- Nat Prod Sci.
- 2016 Jun;22(2):129-133.
- doi: 10.20307/nps.2016.22.2.129
Bioactivity-guided fractionation of a methanolic extract of Buddleja officinalis led to the isolation of two monoterpenes, crocusatin M (1), crocusatin C (2), a flavonoid, acacetin (3), three lignans, lariciresinol (4),... -
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- Diarylbutane-type Lignans from Myristica fragrans (Nutmeg) show the Cytotoxicity against Breast Cancer Cells through Activation of AMP-activated Protein Kinase
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Le TV, Nguyen PH, Choi HS, Yang JL, Kang KW, Ahn SG, Oh WK
- KMID: 2376495
- Nat Prod Sci.
- 2017 Mar;23(1):21-28.
- doi: 10.20307/nps.2017.23.1.21
In our program to search for new AMP-activated protein kinase (AMPK) activators from plants that exert potential anticancer property, we found that an EtOAc extract of Myristica fragrans (nutmeg) activated... -
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- Lignans with NADPH Oxidase 2 (NOX2)-inhibitory Activity from the Fruits of Schisandra chinensis
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Park JM, Pel P, Chin YW, Lee MY
- KMID: 2409611
- Nat Prod Sci.
- 2018 Mar;24(1):59-65.
- doi: 10.20307/nps.2018.24.1.59
An isoform of NADPH oxidase (NOX), NOX2 is a superoxide-generating enzyme involved in diverse pathophysiological events. Although its potential as a therapeutic target has been validated, there is no clinically... -
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- Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents
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Lee JH, Sun YN, Kim YH, Lee SK, Kim HP
- KMID: 2170543
- Biomol Ther.
- 2016 Jan;24(1):67-74.
- doi: 10.4062/biomolther.2015.070
In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as... -
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- The Study of Pytoestrogen Intake and Bone Mineral Density of Vegetarian and Nonvegetarian Postmenopausal Women
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Kim MH, Choi MK, Sung CJ
- KMID: 2232876
- Korean J Community Nutr.
- 2004 Feb;9(1):66-72.
There is some evidence that phytostrogen plays an important role in bone metabolism in postmenopausal women. In this study, we investigated the phytoestrogen intake levels and the relation between dietary... -
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- Schisantherin B Improves the Pathological Manifestations of Mice Caused by Behavior Desperation in Different Ages-Depression with Cognitive Impairment
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Xu M, Xiao F, Wang M, Yan T, Yang H, Wu B, Bi K, Jia Y
- KMID: 2442007
- Biomol Ther.
- 2019 Feb;27(2):160-167.
- doi: 10.4062/biomolther.2018.074
Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.)... -
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- Effects of Schisandra chinensis fruit extract and gomisin A on the contractility of penile corpus cavernosum smooth muscle: a potential mechanism through the nitric oxide - cyclic guanosine monophosphate pathway
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Choi BR, Kim HK, Park JK
- KMID: 2420994
- Nutr Res Pract.
- 2018 Aug;12(4):291-297.
- doi: 10.4162/nrp.2018.12.4.291
BACKGROUND/OBJECTIVES: This study evaluated the effects and molecular mechanisms of the Schisandra chinensis fruit extract (SC) and its major compound gomisin A (GA), on the contractility of rabbit penile corpus... -
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- Anticancer Effect of Magnolia officinalis' Extract on N-butyl-N-(4-hydroxybutyl) Nitrosamine Induced Bladder Cancer in Mice
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Lee SC, Jung P, Kim YJ, Yun SJ, Lee SC, Kim WJ
- KMID: 2311944
- Korean J Urol.
- 2008 Aug;49(8):682-687.
PURPOSE: Magnolia officinalis has been used in traditional Chinese medicine to treat a variety of diseases. The main constituents of Magnolia officinalis are honokiol and magnolol, which have a variety... -
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- Dihydrobenzofuran Neolignans Isolated from Euonymus alatus Leaves and Twigs Attenuated Inflammatory Responses in the Activated RAW264.7 Macrophage Cells
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Kim NH, Yang MH, Heo JD, Sung SH, Jeong EJ
- KMID: 2312922
- Nat Prod Sci.
- 2016 Mar;22(1):53-59.
- doi: 10.20307/nps.2016.22.1.53
Anti-inflammatory effects of dihydrobenzofuran neolignans isolated from Euonymus alatus leaves and twigs were evaluated in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Six neolignans, (+)- simulanol (1), (+)-dehydrodiconiferyl alcohol (2), (-)-simulanol (3),... -
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- Transcriptome Analysis of the Effects of Gomisin A on the Recovery of Carbon Tetrachloride-Induced Damage in Rat Liver
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Choi YM, Choi IS, Lee SM, Hwang DY, Choi YW, Park YH
- KMID: 2053666
- Lab Anim Res.
- 2011 Jun;27(2):161-169.
- doi: 10.5625/lar.2011.27.2.161
Gomisin A possesses a hepatic function-facilitating property in liver-injured rats. Its preventive action on carbon tetrachloride-induced cholestasis is due to maintenance of the function of the bile acids-independent fraction. To... -
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- Effects of Phytoestrogens on Glucose Metabolism in C57BL/KsOlaHsd-db/db Mice
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Seo BH, Kim KO, Lee JH, Lee HS
- KMID: 2268543
- Korean J Nutr.
- 2011 Aug;44(4):275-283.
- doi: 10.4163/kjn.2011.44.4.275
This study was conducted to evaluate the antihyperglycemic effects of three phytoestrogens, genistein, coumestrol, and enterolactone, in type 2 diabetic animals. Forty male C57BL/KsOlaHsd-db/db mice were used as a diabetic... -
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- Magnolol Inhibits LPS-induced NF-kappaB/Rel Activation by Blocking p38 Kinase in Murine Macrophages
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Li MH, Kothandan , Cho SJ, Huong PT, Nan YH, Lee KY, Shin SY, Yea SS, Jeon YJ
- KMID: 2071705
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):353-358.
- doi: 10.4196/kjpp.2010.14.6.353
This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit LPS-induced expression of iNOS gene and activation of NF-kappaB/Rel in RAW 264.7 cells.... -
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- Effects of a safflower tea supplement on antioxidative status and bone markers in postmenopausal women
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Cho SH, Jang JH, Yoon JY, Han CD, Choi Y, Choi SW
- KMID: 2313494
- Nutr Res Pract.
- 2011 Feb;5(1):20-27.
We conducted this study to examine the effects of safflower seed granular tea containing physiologically active polyphenols on antioxidative activities and bone metabolism. Forty postmenopausal women ages 49 to 64-years... -
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- Effects of Supplementation with a Schizandrin C Derivative DDB-mixed Preparation (DWP-04) on Antioxidant Activity in Cisplatin-induced Nephrotoxicity in Rats
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Choi J, Kang HO, Jung YS, Rim H, Hur B
- KMID: 2080046
- Korean J Nephrol.
- 2010 Jan;29(1):3-16.
PURPOSE: This study investigated the effect of reducing cisplatin induced nephrotoxicity with DWP-04 that is the compound of Schizandrin C derivative biphenyldimethyl dicarboxylate (DDB), glutathione and selenium. For the purpose... -
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- Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IkappaB/NF-kappaB, in atherosclerotic cell model
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Qiu L, Xu R, Wang S, Li S, Sheng H, Wu J, Qu Y
- KMID: 2155425
- Exp Mol Med.
- 2015 Jul;47(7):e171.
- doi: 10.1038/emm.2015.37
Pentraxin 3 (PTX3) was identified as a marker of the inflammatory response and overexpressed in various tissues and cells related to cardiovascular disease. Honokiol, an active component isolated from the... -
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- Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity
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Hu J, Chen LJ, Liu L, Chen X, Chen PL, Yang G, Hou WL, Tang MH, Zhang F, Wang XH, Zhao X, Wei YQ
- KMID: 1072942
- Exp Mol Med.
- 2008 Dec;40(6):617-628.
- doi: 10.3858/emm.2008.40.6.617
Honokiol is an active compound purified from magnolia that has been shown to induce cell differentiation, apoptosis, and anti-angiogenesis effects, as well as an enhancement in tumor growth delay in... -
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- 5-Formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway
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Zhu W, Fu A, Hu J, Wang T, Luo Y, Peng M, Ma Y, Wei Y, Chen L
- KMID: 1109403
- Exp Mol Med.
- 2011 Mar;43(3):146-152.
- doi: 10.3858/emm.2011.43.3.017
Our previous report has demonstrated that 5-formylhonokiol (FH), a derivative of honokiol (HK), exerts more potent anti-proliferative activities than honokiol in several tumor cell lines. In present study, we first... -
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