Nutr Res Pract.  2011 Feb;5(1):20-27.

Effects of a safflower tea supplement on antioxidative status and bone markers in postmenopausal women

• Cho SH
• Jang JH
• Yoon JY
• Han CD
• Choi Y
• Choi SW

Abstract

We conducted this study to examine the effects of safflower seed granular tea containing physiologically active polyphenols on antioxidative activities and bone metabolism. Forty postmenopausal women ages 49 to 64-years were recruited from Daegu and Gyeongbuk and were randomly assigned to either a safflower tea supplement (Saf-tea) group (n = 27) or a placebo group (n = 13). The Saf-tea group received 20 g of safflower seed granule tea per day containing a 13% ethanol extract of defatted safflower seeds, whereas the placebo group received a similar type of tea that lacked the ethanol extract. No significant changes in nutrient intake for either the placebo or Saf-tea groups were observed before or after the study period, except vitamin A intake increased after 6 months in the Saf-tea group. Dietary phytoestrogen intakes were similar in the Saf-tea group (60.3 mg) and placebo group (52.5 mg). Significant increases in plasma genistein and enterolactone were observed in the Saf-tea group. After 6 months of supplementation, serum levels of antioxidant vitamins such as alpha-tocopherol and ascorbic acid increased significantly, and TBARS levels decreased in the Saf-tea group compared to the placebo group. Serum osteocalcin levels were reduced (P < 0.05) in the Saf-tea group after 6 months, whereas serum osteocalcin did not change in the placebo group. Urinary deoxypyridinoline/creatinine excretion was not different between the two groups at baseline, and did not change in either group after 6 months. Bone mineral density decreased significantly in the placebo group (P < 0.01) but not in the supplemented group. It was concluded that polyphenols (72 mg/day), including serotonin derivatives, in the Saf-tea had both antioxidant and potential bone protecting effects in postmenopausal women without liver toxicity.

Keyword

Safflower tea; postmenopausal women; antioxidant; bone marker

MeSH Terms

4-Butyrolactone
alpha-Tocopherol
Ascorbic Acid
Bone Density
Carthamus tinctorius
Ethanol
Female
Genistein
Humans
Lignans
Liver
Osteocalcin
Phytoestrogens
Plasma
Polyphenols
Seeds
Serotonin
Tea
Thiobarbituric Acid Reactive Substances
Vitamin A
Vitamins
4-Butyrolactone
Ascorbic Acid
Ethanol
Genistein
Lignans
Osteocalcin
Phytoestrogens
Polyphenols
Serotonin
Tea
Thiobarbituric Acid Reactive Substances
Vitamin A
Vitamins
alpha-Tocopherol

Figure

• 

  Fig. 1 Changes in serum cocnentrations of retinol, α-tocopherol and ascorbic acid of the subjects after three and six months of safflower tea supplementation. *,**Significantly different from baseline by paired t-test at P < 0.05 and P < 0.001. ***Significantly different from baseline by paired t-test at P < 0.001 and from placebo group by ANCOVA at P < 0.05.

• 

  Fig. 2 Changes in serum cocnentrations of TBARS of the subjects after three and six months of safflower tea supplementation. **Significantly different from baseline by paired t-test and from placebo group by ANCOVA at P < 0.05.

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