Alterations of Biochemical Markers in Osteoporotic Fractures

Seo, Jae Sung; Lee, Kwang Hee; Jang, Woo Hyuk

Abstract

Hip fracture is one of the most severe consequence of osteoporosis affecting aged women. Biochemical markers of bone formation and bone resorption allow for a noninvasive assessment of the bone turnover alteration of the entire skeleton in osteoporosis. To evaluate the bone metabolic status of postmenopausal women who sustained hip fractures, we measured serum osteocalcin levels as a bone formation markers, and urinary deoxypyridinoline levels as a bone resorption markers. Comparison was made with-age-matched controls. At the time of admission, serum osteocalcin was 23% lower in the fractured patients compared to controls and urine deoxypyridinoline was 22% higher than in the controls(P<0.05). Hip fracture patients have biochemical evidence of decreased bone formation and increased bone resorrtion compared to controls. Increased bone resorrtion was considered more important factor than bone formation in the postmenopausal osteoporotic hip fracture. Since fracture pathogenesis is complex, various factors, such as osteoporosis and risk factors for injury, have been considered. We suggest that abnormal level of osteocalcin and deoxypyridinoline in Postmenopausal women could be contribute a factor of fracture pathogenesis.