- Ketanserin in the Treatment of Essential Hypertension Over 55 Years Old
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Lee BH, Kim JH, Lim HK, Lee CK
- KMID: 1938112
- Korean Circ J.
- 1990 Sep;20(3):469-473.
- doi: 10.4070/kcj.1990.20.3.469
The effect of ketanserin, serotonin antagonist, among 19 korean patients over 55 years with essential hypertension was assessed in an open clinical trial for three months. patients were given Ketanserin... -
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- Antihypertensive Effects of Ketanserin in Patients Aging Over 55 with Essential Hypertension
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Hong TJ, Chung NS, Shim WH, Cho SY, Kim SS, Lee WK
- KMID: 2229148
- Korean Circ J.
- 1991 Jun;21(3):614-619.
- doi: 10.4070/kcj.1991.21.3.614
To evaluate the antihypertensive effects of serotonin antagonist, ketanserin, a daily dosage of 10~40mg (18.9+/-6.8 mean+/-SE) was administered to 22 patients with essential hypertension and aged 55??1 years (64+/-7.7 mean+/-SE)... -
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- Effect of ketanserin and positive end expiratory pressure ventilation on hemodynamics and gas exchange in experimental acute pulmonary embolism
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Lee SD, Lee YH, Han SK, Shim YS, Kim KY, Han YC
- KMID: 2049917
- Tuberc Respir Dis.
- 1993 Apr;40(2):135-146.
No abstract available. -
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- Ketanserin and Naftopidil Enhance the Potentiating Effect of Alpha-Methyl-Serotonin on the Neurally-Induced Contraction of Human Isolated Urinary Bladder Muscle Strips
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Hattori T, Lluel P, Rouget C, Rekik M, Yoshiyama
- KMID: 2375590
- Int Neurourol J.
- 2017 Mar;21(1):20-28.
- doi: 10.5213/inj.1732758.379
PURPOSE: The aim of this study was to assess the potential involvement of a specific subtype of 5-hydroxytryptamine (5-HT), 5HT(2) receptors in neurally-induced contractions of the human detrusor. METHODS: Contractile responses... -
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- N-( 4-[ 18F ] Fluoromethylbenzyl ) spiperone: A Selective Radiotracer for In Vivo Studies of Dopamine D2 Receptors
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Kim SE, Choe YS, Chi DY, Lee KH, Choi Y, Kim BT
- KMID: 2078655
- Korean J Nucl Med.
- 1997 Nov;31(4):421-426.
We evaluated the in vivo kinetics, distribution, and pharmacology of N-(4-[F] fluorornethylbenzyl)spiperone ([F]FMBS), a newly developed derivative of spiperone, as a potentially more selective #radiotrar.er for the dopamine (DA) Dz... -
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- Effect of 5-HT2c Receptor Modulation on the m-Chlorophenlpiperazine-Induced Hypoactivity
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Jang WS, Byun WT, Chung YI, Lee WS
- KMID: 2287000
- Korean J Psychopharmacol.
- 1997 Apr;8(1):107-112.
It was aimed to investigate the effect of 5-HT2C receptor modulation on the rat behavioral responses induced by 1-(m-chlorophenyl) piperazine(mCPP), a major metabolite of trazodone. The animal activities(ambulation, stereotypy and... -
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- Effect of Centrally-administered DOI, a 5-HT2 Receptor Agonist, on the Regulation of Rabbit Renal Nerve Activities
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Lim YC, Kim HJ, Baik YH
- KMID: 2116754
- Chonnam Med J.
- 2002 Jun;38(2):99-106.
Centrally-administered DOI [1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane HCl], a selective 5-HT2 agonist, has been observed to elicit antidiuresis and antinatriuresis in rabbits. Renal nerves has been suggested to be closely related with this renal... -
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- Preventive Effect of Serotonergic Drugs on LPS-Induced Acute Anorexia in Rats
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Park SY, Kim KH, Ahn DK, Park TI, Kim JY, Kim YW, Lee DC, Lee SK
- KMID: 1600056
- Korean J Physiol Pharmacol.
- 2005 Jun;9(3):149-153.
The aim of the present study was to determine whether serotonergic drugs could reverse lipopolysaccharide (LPS) -induced anorexia in rats. LPS (500microgram/kg body weight) and all serotonergic drugs, except for... -
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- Renal functional responses to a centrally-administered 5-HT-1A agonist in the anesthetized rabbits
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Lim YC, Kim KS, Kook YJ, Koh JT
- KMID: 2285175
- Korean J Physiol Pharmacol.
- 1997 Jun;1(3):315-323.
Central tryptaminergic system has been shown to play an important role in the regulation of renal function: 5-HT-1 (5-hydroxytryptamine-1) receptors might seem to mediate the diuresis and natriuresis, whereas the 5-HT-2 and 5-HT-3... -
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- Effect of Trazodone on the Rat Cerebral Hemodynamics
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Hong JY, Byoun WT, Shin HK, Ko SY, Lee WS
- KMID: 2287015
- Korean J Psychopharmacol.
- 1999 Apr;10(1):71-79.
OBJECTIVES: The present study assessed the effect of trazodone on the cerebral hemodynamics of male Sprague-Dawley rats. METHOD: The changes of regional cerebral blood flow(rCBF) and pill arterial diameter were... -
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- The Role of 5-HT Receptors on the Acetylcholine Release from the Rat Striatum
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Joo YH, Jung KY, Choi BK
- KMID: 1607282
- Korean J Psychopharmacol.
- 2001 Jun;12(2):140-146.
The aim of this study was to investigate the role of the 5-HT receptors in acetylcholine (ACh) release from the striatum. Slices from the rat striatum and synaptosomes were incubated... -
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- Glucosylsphingosine Activates Serotonin Receptor 2a and 2b: Implication of a Novel Itch Signaling Pathway
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Afzal R, Shim WS
- KMID: 2389381
- Biomol Ther.
- 2017 Sep;25(5):497-503.
- doi: 10.4062/biomolther.2016.207
Recent reports claimed that glucosylsphingosine (GS) is highly accumulated and specifically evoking itch-scratch responses in the skins of atopic dermatitis (AD) patients. However, it was unclear how GS can trigger... -
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- Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline Ileal Longitudinal Smooth Muscle
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Wang Y, Park SY, Oh KH, Min Y, Lee YJ, Lee SY, Sohn UD
- KMID: 2071728
- Korean J Physiol Pharmacol.
- 2011 Oct;15(5):267-272.
- doi: 10.4196/kjpp.2011.15.5.267
A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes.... -
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- Role of 5-Hydroxytryptamine in Non-Adrenergic Non-cholinergic Relaxation of the Circcular Muscle from Rat Stomach Fundus
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Kim JH, Kang PJ, Kim CH, Cho SR, Lee IT, Park JH, Kim CH, Rhim BY
- KMID: 2084756
- Korean J Gastroenterol.
- 1997 Oct;30(4):433-444.
BACKGROUND AND AIMS: Gastrointestinal smooth muscle is innervated bv non-adrenergic, non-cholinergic (NANC) inhibitory neurons. These inhibitory enteric neurons play an important role in gastrointestinal motility, and are involved in receptive... -
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- Neurobehavioral teratology due to hypoxic exposure in newborn rats
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Lee SS, Lee S, Kang DW, Kim JS, Kim DG
- KMID: 2342639
- J Korean Neurol Assoc.
- 1998 Apr;16(2):143-154.
BACKGROUND AND PURPOSE: Neurobehavioral teratology is a term used for the postnatal effects on behavior of prenatal exposure to drug or to specific environment. Perinatal hypoxia is a major... -
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- Facilitation of serotonin-induced contraction of rat mesenteric artery by ketamine
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Park SW, Noh HJ, Kim JM, Kim B, Cho SI, Kim YS, Woo NS, Kim SH, Bae YM
- KMID: 2364264
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):605-611.
- doi: 10.4196/kjpp.2016.20.6.605
Ketamine is an anesthetic with hypertensive effects, which make it useful for patients at risk of shock. However, previous ex vivo studies reported vasodilatory actions of ketamine in isolated arteries.... -
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- Serotonin(5-HT): can it be a cause in overactive bladder
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Kim HJ, Lee SJ
- KMID: 2330455
- J Korean Continence Soc.
- 2001 Jun;5(1):39-47.
- doi: 10.5213/jkcs.2001.5.1.39
PURPOSE: The purpose of this study is to investigate in vitro the effects of serotonin on the rat detrusor. In particular, this study examines what drugs inhibit the serotonin-induced detrusor... -
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- Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase
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Sung DJ, Noh HJ, Kim JG, Park SW, Kim B, Cho H, Bae YM
- KMID: 2154286
- Exp Mol Med.
- 2013 Dec;45(12):e67.
Serotonin (5-hydroxytryptamine (5-HT)) is a neurotransmitter that regulates a variety of functions in the nervous, gastrointestinal and cardiovascular systems. Despite such importance, 5-HT signaling pathways are not entirely clear. We... -
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