Korean Circ J.  1991 Jun;21(3):614-619. 10.4070/kcj.1991.21.3.614.

Antihypertensive Effects of Ketanserin in Patients Aging Over 55 with Essential Hypertension

• Hong TJ
• Chung NS
• Shim WH
• Cho SY
• Kim SS
• Lee WK

• KMID: 2229148
• DOI: http://doi.org/10.4070/kcj.1991.21.3.614

Abstract

To evaluate the antihypertensive effects of serotonin antagonist, ketanserin, a daily dosage of 10~40mg (18.9+/-6.8 mean+/-SE) was administered to 22 patients with essential hypertension and aged 55??1 years (64+/-7.7 mean+/-SE) for 12 weeks. After 12 weeks of ketanserin treatment mean blood pressure decreased from 177.9+/-11.9 to 15.7+/-15.3mmHg in systole and from 104.2+/-7.4 to 88.4+/-7.9mmHg in diastole (P<0.001). There was no significant change in heart rates with ketanserin treatment. The antihypertensive treatment with ketanserin was effective in 18 patients(81.8%) and ineffective in 4 patients (18.2%). Adverse reactions such as drowsiness (8.7%), edama (4.3%) and weakness (4.3%) were noted, but all were mild and transient. This results suggest that ketanserin is an effective and safe antihypersive agent in the treatment of essential hyperension.

MeSH Terms

Aging*
Blood Pressure
Diastole
Heart Rate
Humans
Hypertension*
Ketanserin*
Serotonin
Sleep Stages
Systole
Ketanserin
Serotonin