Korean Circ J.  1990 Sep;20(3):469-473. 10.4070/kcj.1990.20.3.469.

Ketanserin in the Treatment of Essential Hypertension Over 55 Years Old

• Lee BH
• Kim JH
• Lim HK
• Lee CK

• KMID: 1938112
• DOI: http://doi.org/10.4070/kcj.1990.20.3.469

Abstract

The effect of ketanserin, serotonin antagonist, among 19 korean patients over 55 years with essential hypertension was assessed in an open clinical trial for three months. patients were given Ketanserin 20mg bid with monthly follow-up visits. Mean values of systolic/diastolic blood pressures fell from 169+/-17/104+/-10mmHg to 155+/-14/94+/-9mmHg at 2 weeks(p<0.01) and to 147+/-10/87+/-6mmHg at end of treatment 12 weeks after(p<0.001). There was no significant change in heart rate. Transient mild side effects were observed in 5 patients. We conclude that Ketanserin is an effective and safe drug for the treatment of elderly hypertensives.

Keyword

Ketanserin; Serotonin antagonist; Elderly hypertensive

MeSH Terms

Aged
Follow-Up Studies
Heart Rate
Humans
Hypertension*
Ketanserin*
Middle Aged*
Serotonin
Ketanserin
Serotonin