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Mosapride Improves Lower Esophageal Sphincter and Esophageal Body Function in Patients With Minor Disorders of Esophageal Peristalsis

Kim SE, Park MI, Park SJ, Moon W, Kim JH, Jung K, Kwon HJ, Kim GM, Joo HK

  • KMID: 2500680
  • J Neurogastroenterol Motil.
  • 2020 Apr;26(2):232-240.
  • doi: 10.5056/jnm19062
Background/Aims High-resolution manometry (HRM) has broadened the awareness of minor esophageal peristaltic disorders. However, the treatments for these minor disorders are limited and the role of prokinetics has been controversial....
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Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells

Joo HK, Lee YR, Choi S, Park MS, Kang G, Kim CS, Jeon BH

Activation of protein kinase C (PKC) is closely linked with endothelial dysfunction. However, the effect of PKCβII on endothelial dysfunction has not been characterized in cultured endothelial cells. Here, using...
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Altered Secretory Activity of APE1/Ref-1 D148E Variants Identified in Human Patients With Bladder Cancer

Lee YR, Lim JS, Shin JH, Choi S, Joo HK, Jeon BH

  • KMID: 2309837
  • Int Neurourol J.
  • 2016 May;20(Suppl 1):S30-S37.
PURPOSE: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in DNA repair and redox modulation. Recently, serum and urinary APE1/Ref-1 levels were reported to be increased in patients...
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Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein

Choi S, Joo HK, Jeon BH

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that plays a central role in the cellular response to DNA damage and redox regulation against oxidative stress. APE1/Ref-1 functions in...
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Trichostatin A Modulates Angiotensin II-induced Vasoconstriction and Blood Pressure Via Inhibition of p66shc Activation

Kang G, Lee YR, Joo HK, Park MS, Kim CS, Choi S, Jeon BH

Histone deacetylase (HDAC) has been recognized as a potentially useful therapeutic target for cardiovascular disorders. However, the effect of the HDAC inhibitor, trichostatin A (TSA), on vasoreactivity and hypertension remains...
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Redox Regulating Protein APE1/Ref-1 Expression is Increased in Abdominal Aortic Coarctation-induced Hypertension Rats

Song SH, Cho EJ, Park MS, Lee YR, Joo HK, Kang G, Kang SK, Choi S, Jeon BH

  • KMID: 2330961
  • J Korean Soc Hypertens.
  • 2012 Sep;18(3):126-135.
BACKGROUND: Aim of study is designed to investigate whether apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) expression is changed in abdominal aortic coarctation models. METHODS: Male Sprague-Dawley rats were randomly assigned with abdominal aortic...
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Tat-Mediated p66shc Transduction Decreased Phosphorylation of Endothelial Nitric Oxide Synthase in Endothelial Cells

Lee SK, Lee JY, Joo HK, Cho EJ, Kim CS, Lee SD, Park JB, Jeon BH

We evaluated the role of Tat-mediated p66shc transduction on the activation of endothelial nitric oxide synthase in cultured mouse endothelial cells. To construct the Tat-p66shc fusion protein, human full length...
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Comparison of Isokinetic Strength between Stage 1,2 Impingement Syndrome and Rotator Cuff Tear

Kim DW, Joo HK, Jung JE

  • KMID: 2101932
  • J Korean Shoulder Elbow Soc.
  • 2010 Jun;13(1):53-57.
PURPOSE: The goal of this study was to evaluate differences in strength deficits between (i) patients with stage 1 or 2 impingement syndrome and (ii) patients with rotator cuff tears. MATERIALS...
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False Negative Bone Scan in 56-year Old Man with L2 Compression Fracture Performed 78 Hours after Trauma: A Case Report

Seo JG, Joo HK, Kim ST

It is very rare that the bone scan after 72 hours from the trauma doesn't exhibit the increased radio-nuclide uptake in the patient with fracture. The purpose of this study...
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Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase

Lee KH, Lee SK, Kim HS, Cho EJ, Joo HK, Lee EJ, Lee JY, Park MS, Chang SJ, Cho CH, Park JB, Jeon BH

The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Pb caused progressive cellular death in endothelial cells, which occurred...
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NADPH Oxidase and Mitochondrial ROS are Involved in the TNF-alpha-induced Vascular Cell Adhesion Molecule-1 and Monocyte Adhesion in Cultured Endothelial Cells

Yu JH, Kim CS, Yoo DG, Song YJ, Joo HK, Kang G, Jo JY, Park JB, Jeon BH

  • KMID: 1587401
  • Korean J Physiol Pharmacol.
  • 2006 Aug;10(4):217-222.
Atherosclerosis is considered as a chronic inflammatory process. However, the nature of the oxidant signaling that regulates monocyte adhesion and its underlying mechanism is poorly understood. We investigated the role...
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The clinical efficacy and cost-effectiveness of Lamellar body count in fetal lung maturation test

Hong SP, Park EK, Jeong SY, Joo HK, Lee JH, Moon HB, Koh YM, Shin JC, Kim CY

  • KMID: 2076736
  • Korean J Obstet Gynecol.
  • 2002 Nov;45(11):1951-1955.
OBJECTIVE: To evaluate the availability and efficacy of the Lamellar body count as a predictor of fetal lung maturity METHODS: Amniocentesis was performed for evaluation of fetal lung maturity status within...
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A Case of Malignant Lymphoma originated from uterine cervix

Rhim CC, Roh SR, Kim DJ, Song MK, Lee JS, Joo HK, Park YH, Ryu KS, Han GT, Lee JK, Lee JM, Namkoong S

  • KMID: 2262360
  • Korean J Obstet Gynecol.
  • 2001 Aug;44(8):1558-1561.
The malignant lymphomas are neoplastic transformation of cells that reside predominantly in lymphoid tissues. The two major variants of malignant lymphoma are non-Hodgkin's lymphoma and Hodgkin's disease. Although both of...
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A case of Edward syndrome with radius aplasia

Joo HK, Park YH, Lee JH, Moon HB, Kim SJ, Yi CS, Shin JC, Kim SP

  • KMID: 2262432
  • Korean J Obstet Gynecol.
  • 2001 Oct;44(10):1937-1940.
Trisomy 18 is the second most common chromosomal anomaly that reach to live birth after Down syndrome. Several methods were proposed to screen patients on the risk of Edward syndrome...
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Clinical Studies on Risk Facotrs of Recurrnces after First Febrile Convulsions in Infancies and Early Childhood

Chun HK, Joo HK, Ahn MS, Oh JS

  • KMID: 2142449
  • J Korean Pediatr Soc.
  • 1994 Jun;37(6):786-793.
The aim of this study was to evaluate the risk factors of recurrences after their first febrile convulsions in infants and young children. Dlinical studies were made on 187 cases...
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A study on Purification of Water Works by Multi-filter Bed Method with Aeration: Application of Biological Oxidation by Aerobic Microorganism

Chung YH, Moon JK, Joo HK, Seo HJ

  • KMID: 2281849
  • Korean J Prev Med.
  • 1972 Nov;5(1):43-48.
5 bed sand filter, applying biological oxidation, was designed and studied on the treatment of water works. Never using any coagulant agent (drugs), which may cause water pollution in pre-treatment...
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A study on Public Nuisance in Kwangju City: Surey on Air Pollution and Noise Level

Chung YH, Kim KW, Moon JK, Joo HK

  • KMID: 2281840
  • Korean J Prev Med.
  • 1972 Nov;5(1):1-7.
During the period from June 1st 1971 to November 30th 1971, studies on air polluton were made in Kwangju city. The city was divided into 6 areas : the downtown...
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