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Regulation of Osteoclast Differentiation by Cytokine Networks

Amarasekara DS, Yun H, Kim S, Lee N, Kim H, Rho J

Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand...
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Immune Characterization of Bone Marrow-Derived Models of Mucosal and Connective Tissue Mast Cells

Benedé S, Cody E, Agashe C, Berin MC

PURPOSE: It is well appreciated that mast cells (MCs) demonstrate tissue-specific imprinting, with different biochemical and functional properties between connective tissue MCs (CTMCs) and mucosal MCs (MMCs). Although in vitro...
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The Effect of Caffeine on 3T3-L1 Adipocyte Differentiation : A Nutrigenomical Approach

Kim MJ, Kim Y, Chung JH, Kim JW, Kim HK

  • KMID: 2257587
  • Korean J Nutr.
  • 2005 Oct;38(8):649-655.
Nutrigenomics refers to research that investigates the interaction between nutrition and the human genome. Caffeine in tea and coffee is widely and routinely consumed by people. This study was performed...
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In Vitro Effect of Interleukin-11 (IL-11) on Megakaryopoiesis from Umbilical Cord Blood Cells

Lee KK, Kim CK, Lee NS, Kim SJ, Cheong HJ, Lee KT, Park SK, Baick SH, Won JH, Hong DS, Park HS

BACKGROUND: The megakaryopoiesis and platelet production is regulated by several hematopoietc factors such as thrombopoietin (TPO), interleukin-11 (IL-11) and interleukin-3 (IL-3). IL-11 is a potent stimulator of megakaryopoiesis in vivo,...
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The Effects of Cyclosporin A and FK-506 on the Cytokine Production of Lymphocytes in Atopic Dermatitis

Park CW, Lee KY, Lee EH, Lee CH

BACKGROUND: It has been demonstrated that patients with atopic dermatitis(AD) show an impaired capacity of their T cells to release of interleukin-2(IL-2) in vitro and elevated serum levels of soluble...
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Studies of cocktail therapy with multiple cytokines for neoplasia or infectious disease of the dog I. cDNA cloning of canine IL-3 and IL-6

Shin IS, Kim HR, Nam MJ, Youn HY

  • KMID: 1103518
  • J Vet Sci.
  • 2001 Aug;2(2):115-120.
This paper describes the cloning and sequence analysis of the cDNAs encoding the canine homologues of interleukin-3 (IL-3) and interleukin-6 (IL-6). The coding sequences for canine IL-3 and IL-6 were...
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The role of dependent pathway in eosinophil apoptosis

Ki SY, Jeon KW, Lee MR, Uh ST, Kim YH, Park CS, Chung IY

  • KMID: 2286031
  • J Asthma Allergy Clin Immunol.
  • 1999 Oct;19(5):667-684.
BACKGROUND: Interleukin-5 (IL-5), IL-3, and GM-CSF are known to prolong the survival of eosinophils, and IL-5 has the most potent effect on eosinophil survivaL It is also known that divergent signals induce...
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In vitro Biphasic Effect of Honey Bee Venom on Basophils from Screened Healthy Blood Donors

Chirumbolo S, Zanoni G, Ortolani R, Vella A

Apis mellifera L. bee venom is the most studied hymenoptera allergen, but many aspects of its action on human basophils remain unclear. Allergologists seek evidence of the effectiveness of bee...
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The Effect of glucocorticoid on the change of nitric oxide and cytokine levels in induced sputum from patients with bronchial asthma

Kim TY, Yoon HK, Choi YM, Lee SY, Kwon SS, Kim YK, Kim KH, Moon HS, Park SH, Song JS

BACKGROUND: It has been well known that bronchial asthma is a chronic airway inflammatory disorder. Recently, sputum specimen induced with hypertonic saline was introduced as a simple and useful noninvasive...
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Differentiation of human CD14+ monocytes: an experimental investigation of the optimal culture medium and evidence of a lack of differentiation along the endothelial line

Safi W, Kuehnl A, Nüssler A, Eckstein H, Pelisek J

The aim of this study was to determine the optimal culturing media for human CD14+ monocytes and to evaluate whether these cells are capable of differentiating into vascular endothelial cells....
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Characterization of IL-3, IL-5, GM-CSF-induced Eosinophils from Human CD34+ Cord Blood Cells

Lee KS, Ahn KM, Nam SY, Son DY, Ham SC, Han MY, Lee SI

  • KMID: 1994354
  • Pediatr Allergy Respir Dis.
  • 1999 Dec;9(4):412-420.
PURPOSE: Eosinophils are cells of the granulocyte lineage that participate in host defence against parasitic disease and mediate allergic inflammation. In this study by using the combination of cytokines IL-3,...
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Ex Vivo Expansion of Primitive Hematopoietic Cells by Using Hematopoietic Growth Factors

Sung KW, Lee JA, Yoo KH, Kim DH, Jung HL, Koo HH, Shin HY, Ahn HS

  • KMID: 2278229
  • Korean J Pediatr Hematol Oncol.
  • 2001 Apr;8(1):110-119.
PURPOSE: If primitive hematopoietic cells expanded ex vivo can be used in stem cell transplantation, duration for hematologic recovery will be shortened. In this study, CD34 cells were cultured with...
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