- Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
-
Nakajima H, Hirose K
- KMID: 1456191
- Immune Netw.
- 2010 Feb;10(1):1-4.
- doi: 10.4110/in.2010.10.1.1
Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as... -
- CITED
-
- Close
- SHARE
-
- Close
- Regulation of Osteoclast Differentiation by Cytokine Networks
-
Amarasekara DS, Yun H, Kim S, Lee N, Kim H, Rho J
- KMID: 2404891
- Immune Netw.
- 2018 Feb;18(1):e8.
- doi: 10.4110/in.2018.18.e8
Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand... -
- CITED
-
- Close
- SHARE
-
- Close
- A Case of Paradoxical Flare of Pustular Psoriasis after Ustekinumab Therapy
-
Kang IH, Shin MK, Lee MH, Jeong KH
- KMID: 2436996
- Korean J Dermatol.
- 2018 Nov;56(9):548-551.
Biologics are the most advanced treatment for psoriasis. Ustekinumab, one of the biologics for psoriasis, is a human monoclonal antibody that binds to the p40 subunit of interleukin-12 and interleukin-23.... -
- CITED
-
- Close
- SHARE
-
- Close
- Targeting Interleukin-17 and Th17 in Immune Inflammatory Diseases
-
Cho MR
- KMID: 2168216
- Hanyang Med Rev.
- 2013 Feb;33(1):17-26.
- doi: 10.7599/hmr.2013.33.1.17
Th17 cells (Th17) are a distinct lineage of CD4+ T cells that secrete high amounts of IL-17 under orphan nuclear receptor retinoic acid receptor-related orphan receptor gammat (RORgammat) which is... -
- CITED
-
- Close
- SHARE
-
- Close
- Screening of Interleukin-12/interleukin-23 p40 Inducers in Rheumatoid Synovial Fluids by Fluorescence Reporter Mouse System
-
Kim J, Cho ML, Hong S, Kim WK, Youn J
- KMID: 1583640
- Korean J Phys Anthropol.
- 2006 Sep;19(3):205-214.
Although rheumatoid arthritis has been known to be a common autoimmune disease characterized by chronic inflammation mainly evident in diarthrodial joints, its pathogenesis remains to be clarified. In the present study,... -
- CITED
-
- Close
- SHARE
-
- Close
- Immunohistochemical Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis
-
Song HS, Kim SJ, Park TI, Jang YH, Lee ES
- KMID: 2344815
- Ann Dermatol.
- 2016 Aug;28(4):451-456.
- doi: 10.5021/ad.2016.28.4.451
BACKGROUND: Cutaneous pustular disorders include generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP). OBJECTIVE: To identify differences between GPP and AGEP, here we immunohistochemically evaluated interleukin (IL)-36 and the... -
- CITED
-
- Close
- SHARE
-
- Close
- IL-23 P19 Expression Induced by IL-17 and IL-1beta in Rheumatoid Arthritis Synovial Mononuclear Cells
-
Cho ML, Heo YJ, Oh HJ, Kang CM, Lee SY, Hong YS, Kim HY
- KMID: 2054256
- Immune Netw.
- 2008 Mar;8(1):29-37.
- doi: 10.4110/in.2008.8.1.29
Interleukin-23 (IL-23) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). This study was undertaken to investigate the IL-23 inductive activity... -
- CITED
-
- Close
- SHARE
-
- Close
- Tissue and Serum Inflammatory Cytokine Levels in Korean Psoriasis Patients: A Comparison between Plaque and Guttate Psoriasis
-
Roh NK, Han SH, Youn HJ, Kim YR, Lee YW, Choe YB, Ahn KJ
- KMID: 2157451
- Ann Dermatol.
- 2015 Dec;27(6):738-743.
- doi: 10.5021/ad.2015.27.6.738
BACKGROUND: The phenotypic heterogeneity of psoriasis could be explained by the alternate activation of either T-helper (Th)-1- or Th-17-related cytokines. However, evidence directly supporting this hypothesis is scarce. OBJECTIVE: To characterize... -
- CITED
-
- Close
- SHARE
-
- Close
- Kinetics of IL-23 and IL-12 Secretion in Response to Toxoplasma gondii Antigens from THP-1 Monocytic Cells
-
Quan JH, Zhou W, Cha GH, Choi IW, Shin DW, Lee YH
- KMID: 1501814
- Korean J Parasitol.
- 2013 Feb;51(1):85-92.
- doi: 10.3347/kjp.2013.51.1.85
IL-23 and IL-12 are structurally similar and critical for the generation of efficient cellular immune responses. Toxoplasma gondii induces a strong cell-mediated immune response. However, little is known about IL-23... -
- CITED
-
- Close
- SHARE
-
- Close
- 7alpha-Hydroxycholesterol Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells
-
Seo HC, Kim SM, Eo SK, Rhim BY, Kim K
- KMID: 2380367
- Biomol Ther.
- 2015 Jan;23(1):84-89.
- doi: 10.4062/biomolther.2014.067
We investigated the question of whether 7-oxygenated cholesterol derivatives could affect inflammatory and/or immune responses in atherosclerosis by examining their effects on expression of IL-23 in monocytic cells. 7alpha-Hydroxycholesterol (7alphaOHChol)... -
- CITED
-
- Close
- SHARE
-
- Close
- Co-stimulation of TLR4 and Dectin-1 Induces the Production of Inflammatory Cytokines but not TGF-beta for Th17 Cell Differentiation
-
Chang J, Kim BM, Chang CH
- KMID: 1508826
- Immune Netw.
- 2014 Feb;14(1):30-37.
- doi: 10.4110/in.2014.14.1.30
Collaboration of TLR and non-TLR pathways in innate immune cells, which acts in concert for the induction of inflammatory cytokines, can mount a specific adaptive immune response tailored to a... -
- CITED
-
- Close
- SHARE
-
- Close
- Interleukin 17-expressing Innate Synovial Cells Drive K/Bxn Serum-induced Arthritis
-
Cho WS, Jang E, Kim HY, Youn J
- KMID: 2362801
- Immune Netw.
- 2016 Dec;16(6):366-372.
- doi: 10.4110/in.2016.16.6.366
K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of... -
- CITED
-
- Close
- SHARE
-
- Close
- Pathogenesis of Ankylosing Spondylitis
-
Kim HW, Lee SH
- KMID: 2222907
- J Rheum Dis.
- 2015 Apr;22(2):61-68.
- doi: 10.4078/jrd.2015.22.2.61
Ankylosing spondylitis (AS) is the prototype of spondyloarthritis which shares complex clinical phenotypes and risk factors, both genetic and environmental with other chronic inflammatory disease, e.g. inflammatory bowel disease. Human... -
- CITED
-
- Close
- SHARE
-
- Close
- Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder
-
Kim JW, Kim YK, Hwang JA, Yoon HK, Ko YH, Han C, Lee HJ, Ham BJ, Lee HS
- KMID: 2316303
- Psychiatry Investig.
- 2013 Sep;10(3):294-299.
OBJECTIVE: Cytokines are believed to have a role in the pathophysiology of major depression. The alteration in levels of pro-inflammatory cytokines [interleukin 1beta (IL-1beta), IL-2, IL-6, IL-12, interferon gamma, and... -
- CITED
-
- Close
- SHARE
-
- Close
- IL-12 and IL-23 Production in Toxoplasma gondii- or LPS-Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways
-
Ismail HA, Kang BH, Kim JS, Lee JH, Choi IW, Cha GH, Yuk JM, Lee YH
- KMID: 2403712
- Korean J Parasitol.
- 2017 Dec;55(6):613-622.
- doi: 10.3347/kjp.2017.55.6.613
IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these... -
- CITED
-
- Close
- SHARE
-
- Close
- Recent medical therapy for psoriasis
-
Youn SW
- KMID: 2441069
- J Korean Med Assoc.
- 2019 Mar;62(3):176-180.
- doi: 10.5124/jkma.2019.62.3.176
Psoriasis is a chronic inflammatory disease. Medical therapy is the mainstay of the management of psoriasis, and the main target of psoriasis treatment is immunological dysregulation. Cyclosporine and methotrexate, the... -
- CITED
-
- Close
- SHARE
-
- Close
- The Th17 and Autoimmune Arthritis
-
Cho ML, Heo YJ, Park JS, Lee SY, Sung YC, Kim HY
- KMID: 2150622
- Immune Netw.
- 2007 Mar;7(1):10-17.
- doi: 10.4110/in.2007.7.1.10
Autoimmune arthritis, such as rheumatoid arthritis (RA), is a chronic inflammatory disorder that primarily affects the joints and then results in their progressive destruction. Effector Th cells have been classified... -
- CITED
-
- Close
- SHARE
-
- Close
- The Effect of Inflammatory Cytokines on the Differentiation of Th17 Cells in Human Peripheral Blood
-
Heo YJ, Park MK, Ju JH, Park KS, Cho ML, Kim HY
- KMID: 2202129
- J Korean Rheum Assoc.
- 2009 Jun;16(2):133-143.
- doi: 10.4078/jkra.2009.16.2.133
OBJECTIVE: IL-17-producing T cells (Th17 cells) have been identified as a distinct lineage of CD4+ T helper cells in mice. Since this discovery, many efforts have been made to investigate... -
- CITED
-
- Close
- SHARE
-
- Close
- The Expression of Cytokine and Chemokine Related with Dendritic Cell and Effector T Cell in Psoriatic Lesions
-
Lee KY, Jeon SY, Ko DY, Song KH, Kim KH
- KMID: 2301611
- Korean J Dermatol.
- 2012 Jul;50(7):599-608.
BACKGROUND: T cells and dendritic cells (DCs) are more observed in the psoriatic lesion. Inflammatory DCs stimulate T cell differentiation (Th1 or Th17 cells) by producing IL-12 and IL-23 in... -
- CITED
-
- Close
- SHARE
-
- Close
- Immunomodulatory Effects of Balneotherapy with Hae-Un-Dae Thermal Water on Imiquimod-Induced Psoriasis-Like Murine Model
-
Lee YB, Lee JY, Lee HJ, Yun ST, Lee JT, Kim HJ, Yu DS, Woo SY, Kim JW
- KMID: 2171659
- Ann Dermatol.
- 2014 Apr;26(2):221-230.
- doi: 10.5021/ad.2014.26.2.221
BACKGROUND: Balneotherapy, although not a well-established dermatological treatment, is thought to have therapeutic properties for psoriasis and is used as an alternative treatment modality throughout the world. OBJECTIVE: To evaluate the... -
- CITED
-
- Close
- SHARE
-
- Close
