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Neutralizing Antibodies Against Interferon-Beta in Korean Patients with Multiple Sclerosis

Hyun JW, Kim G, Kim Y, Kong B, Joung A, Park NY, Jang H, Shin HJ, Kim SH, Ahn SW, Shin HY, Huh SY, Kim W, Park MS, Kim BJ, Kim BJ, Oh J, Kim HJ

BACKGROUND AND PURPOSE: Patients treated with interferon-beta (IFN-β) can develop neutralizing antibodies (NAbs) against IFN-β that can negatively affect the therapeutic response. This study assessed the prevalence of NAbs and...
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Anti-proliferative Effect of Engineered Neural Stem Cells Expressing Cytosine Deaminase and Interferon-β against Lymph Node–Derived Metastatic Colorectal Adenocarcinoma in Cellular and Xenograft Mouse Models

Park GT, Kim SU, Choi KC

PURPOSE: Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, genetically engineered human neural stem cells...
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Cerebral Cortex Involvement in Neuromyelitis Optica Spectrum Disorder

Kim W, Lee JE, Kim SH, Huh SY, Hyun JW, Jeong IH, Park MS, Cho JY, Lee SH, Lee KS, Kim HJ

BACKGROUND AND PURPOSE: Brain lesions involving the cerebral cortex are rarely described in patients with neuromyelitis optica spectrum disorder (NMOSD), in contrast to multiple sclerosis. We investigated cerebral cortex involvement...
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Reduction of Disease Activity in Patient with Relapsing-Remitting Multiple Sclerosis after Switching to Teriflunomide from Interferon Beta

Shin KS, Park JG, Park MS

No abstract available.
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Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity

Sung NY, Kim MY, Cho JY

Flavonoids are plant pigments that have been demonstrated to exert various pharmacological effects including anti-cancer, anti-diabetic, anti-atherosclerotic, anti-bacterial, and anti-inflammatory activities. However, the molecular mechanisms in terms of exact target...
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Human Rhinovirus-induced Proinflammatory Cytokine and Interferon-beta Responses in Nasal Epithelial Cells From Chronic Rhinosinusitis Patients

Kim JH, Kim YS, Cho GS, Kim NH, Gong CH, Lee BJ, Jang YJ

PURPOSE: Asthma exacerbation from human rhinovirus (HRV) infection is associated with deficient antiviral interferon (IFN) secretion. Although chronic rhinosinusitis (CRS), an inflammatory upper airway disease, is closely linked to asthma,...
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Long (27-nucleotides) small inhibitory RNAs targeting E6 protein eradicate effectively the cervical cancer cells harboring human papilloma virus

Cho JS, Lee SW, Kim YM, Kim D, Kim DY, Kim YT

OBJECTIVE: This study was to identify small inhibitory RNAs (siRNAs) that are effective in inhibiting growth of cervical cancer cell lines harboring human papilloma virus (HPV) and to examine how...
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Combination Therapy for Gliomas Using Temozolomide and Interferon-Beta Secreting Human Bone Marrow Derived Mesenchymal Stem Cells

Park JH, Ryu CH, Kim MJ, Jeun SS

OBJECTIVE: Malignant gliomas are the most common primary tumors of the central nervous system and the prognosis of patients with gliomas is poor. The combination of interferon-bata (IFN-beta) and temozolomide...
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Role of Cyclic GMP-AMP Synthase in Sensing Human Immunodeficiency Virus

Park YS, Kim IH, Koh YS

Cyclic guanosine monophosphate adenosine monophosphate (cGAMP) synthase (cGAS) detects human immunodeficiency virus (HIV) and produces cGAMP to induce cytokines. Reverse transcribed DNA of HIV is critical for triggering innate immune...
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TRIF Deficiency does not Affect Severity of Ovalbumin-induced Airway Inflammation in Mice

Kim TH, Kim DJ, Park JH, Park JH

Allergic asthma is a chronic pulmonary inflammatory disease characterized by reversible airway obstruction, hyperresponsiveness and eosinophils infiltration. Toll-like receptors (TLRs) signaling are closely associated with asthma and have emerged as...
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Sporadic Porphyria Cutanea Tarda in a Patient with Multiple Sclerosis Treated with Interferon Beta 1-a Therapy: A Case Report

Carrieri P, Petracca M, Montella S, Cerullo G, Cerillo I, Cimmino G

No abstract available.
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Interferon beta-1b Treatment in a Korean Girl with Multiple Sclerosis

Kim HJ, Kim HD, Lee JS, Kang HC

  • KMID: 2329623
  • J Korean Child Neurol Soc.
  • 2013 Mar;21(1):28-32.
Here we report a case of pediatric multiple sclerosis treated with interferon beta-1b. Interferon beta is widely used in adult patients with multiple sclerosis (MS). However, its effects and safety...
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Antibodies to Interferon beta in Patients with Multiple Sclerosis Receiving CinnoVex, Rebif, and Betaferon

Zare N, Zarkesh-Esfahani SH, Gharagozloo M, Shaygannejad V

Treatment with interferon beta (IFN-beta) induces the production of binding antibodies (BAbs) and neutralizing antibodies (NAbs) in patients with multiple sclerosis (MS). NAbs against IFN-beta are associated with a loss...
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Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling

Krishnan J, Choi S

A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of...
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Adenovirus Expressing Human Interferon Inhibits Replication of Foot and Mouth Disease Virus and Reduces Fatal Rate in Mice

Chu JQ, Kim SM, Lee KN, Oem JK, Ko YJ, Lee HS, Kim YJ, Park JY, Kim KJ, Parida S, Oh Y, Paton DJ, Joo YS, Kim B, Park JH

Interferon is an important cytokine that plays a critical role in the initial host defense against viral infection. Recombinant human adenoviruses expressing human interferon-alpha (Ad-HIFNalpha) or pig interferon-beta fused with...
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Calcium/Calmodulin-Dependent Protein Kinase is Involved in the Release of High Mobility Group Box 1 Via the Interferon-beta Signaling Pathway

Ma L, Kim SJ, Oh KI

  • KMID: 2424209
  • Immune Netw.
  • 2012 Aug;12(4):148-154.
Previously, we have reported that high mobility group box 1 (HMGB1), a proinflammatory mediator in sepsis, is released via the IFN-beta-mediated JAK/STAT pathway. However, detailed mechanisms are still unclear. In...
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Basic and Translational Understandings of Microbial Recognition by Toll-Like Receptors in the Intestine

Rhee SH

  • KMID: 2326186
  • J Neurogastroenterol Motil.
  • 2011 Jan;17(1):28-34.
Microbial recognition by multicellular organisms is initially accomplished by a group of pattern recognition receptors which are specialized to recognize microbe-associated molecular patterns (MAMPs) such as lipopolysaccharide, bacterial lipoprotein, CpG...
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GRIM-19 Expression and Function in Human Gliomas

Jin YH, Jung S, Jin SG, Jung TY, Moon KS, Kim IY

OBJECTIVE: We determined whether the expression of GRIM-19 is correlated with pathologic types and malignant grades in gliomas, and determined the function of GRIM-19 in human gliomas. METHODS: Tumor tissues were...
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Multiple Sclerosis

Kim W, Kim HJ

Multiple sclerosis (MS) is an inflammatory autoimmune disorder of the central nervous system (CNS) and one of the most common disabling neurological diseases of young adults. Although the exact mechanisms...
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Recombinant Interferon-Beta-1alpha Plus Ribavirin for the Treatment of Chronic HCV Infection: A Prospective, Randomized, Comparative Pilot Study

Ahn SH, Lee HW, Kim YS, Kim JK, Han KH, Chon CY, Moon YM

  • KMID: 1744235
  • Gut Liver.
  • 2009 Mar;3(1):20-25.
BACKGROUND/AIMS: Interferon beta (IFN-beta) has been shown to have antiviral activity, and thus could be useful in treating viral infections. Therefore, we compared the efficacy and safety of recombinant IFN-beta(IFN-beta-1a)...
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