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Therapeutic Drug Monitoring (TDM) of Antimicrobial Agents

Kim SW

Optimal exposure of certain antimicrobials and minimization of their toxicity can be achieved by therapeutic drug monitoring (TDM) of antimicrobial agents. Vancomycin and aminoglycosides are most frequently monitored because of...
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A Case of Typhoid Fever to Failed Ciprofloxacin, Infected in Korea

Lee KS, Lee HY, Jeon EJ, Chung JW

Typhoid fever caused by Salmonella enterica serovar Typhi (S. typhi) and usually ciprofloxacin is first used for treatment. However, the incidence of fluoroquinolone resistance or reduced susceptibility in S. typhi...
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Pharmacokinetics and Pharmacodynamics of Antibiotics : General Concepts and Recent Advances

Lee DG, Shin HH

Pharmacokinetics (PK) of antibiotics can be considered as the absorption, distribution, and elimination of drug. Pharmacodynamics (PD) is the relationship between concentration of drug and the antimicrobial effect. Time course...
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Two Cases of Vivax Malaria Accompanied by Splenic Complications (such as splenic rupture and splenic infarction)

Jung EJ, Choo EJ, Kim TH, Jeon MH, Lee EJ, Cho YS, Lee HY, Kim JY

Malaria is a protozoan disease transmitted by Anopheles mosquitoes. Since Plasmodium vivax malaria reemerged in the north west areas of South Korea in 1993, many cases with various manifestations have...
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A Case of 'True' Fungus-Infected Aneurysm of Abdominal Aorta in an Immunocompetent Patient

Lee HY, Kim TH, Choo EJ, Jeon MH, Lee EJ, Jung EJ, Jeon SR, Park EJ, Youm W, Jang WH, Hwang JH, Kim DH, Kim DW

Infected aneurysms are uncommon, frequently fatal lesions. "True" fungus-infected aneurysms are even rarer. Fungal infections have high morbidity and mortality. However, diagnosis is frequently difficult, since the symptoms are non-specific...
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Comparison of Real-time PCR Methods and pp65 Antigenemia Assay to Detect Cytomegalovirus Reactivation in Hematopoietic Stem Cell Transplantation

Lee SY, Choi BS, Kim SS, Choi SM, Shin WS, Lee JS

Human cytomegalovirus (HCMV) is a common human pathogen that causes morbidity and mortality in hematopoietic stem cell transplantation (HSCT) recipients. Early diagnosis of HCMV infection or reactivation, and setting threshold...
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A Case of Septic Hip Arthritis Caused by Aspergillus fumigatus in a Liver Transplant Recipient

Kim T, Lee SR, Cho OH, Park KH, Oh R, Lee SO, Kim YS, Woo JH, Kim MN, Choi SH

Septic arthritis is an uncommon finding of invasive Aspergillosis. It can be caused by direct inoculation, post-surgical infection, and hematogenous spread. Articular aspergillosis often involves the knee. A 49-year-old man...
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Efficacy of Cefcapene Pivoxil for Empirical Therapy of Acute Uncomplicated Cystitis

Lee SJ, Ha US, Kim HW, Cho YH

BACKGROUND: A high prevalence of fluoroquinolone resistance among uropathogens has been observed in Korea. Since empirical antimicrobial therapy should be guided by the proportion of pathogens resistant to the chosen...
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Risk Dactors for Death in Patients with Staphylococcus aureus Bacteremia

Moon SY, Lee MS, Son JS, Lee HJ, Lee SO

BACKGROUND: Staphylococcus aureus is a common cause of severe infection and frequently results in death or disability. We investigated potential risk factors influencing clinical outcome in S. aureus bacteremia (SAB)....
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The Pattern of Vaccine Administration Accessed by Vaccine Consumption in a University Hospital

Kim JS, Baek YS, Chung MH, Lee JS, Oh KS

BACKGROUND: Studies on immunization in Korea mainly focus to the coverage rates in recipients. The attitudes of health-care providers regarding immunization are rarely evaluated. Therefore, to assess the pattern of...
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