- Fetal Alveolar Type II Cell Injury Induced by Short-term Exposure to Hyperoxia
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Lee HS
- KMID: 2312942
- Neonatal Med.
- 2013 Aug;20(3):300-310.
A High concentration of oxygen (>40%) is used as a life-saving therapy in preterm newborns since birth. By generating excess reactive oxygen species, however, hyperoxia can cause lung injury leading... -
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- Effect of Short-term Exposure of Different Concentrations of Hyperoxia on Fetal Alveolar Type II Cell Death
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Lee HS
- KMID: 2312929
- Neonatal Med.
- 2013 May;20(2):199-206.
PURPOSE: Lung injury imposed by hyperoxia is the most important cause of bronchopulmonary dysplasia (BPD) in premature lungs, and hyperoxia has the chief biological effect of inducing cell death. The... -
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- Development of Lung Injury and Change in Hyaluronan of Extracellular Matrix by the Effect of Hyperoxia in Neonatal Rat
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Kim BI, Choi JH, Chi JG
- KMID: 1898278
- J Korean Soc Neonatol.
- 2000 Nov;7(2):114-121.
No abstract available. -
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- The Pathophysiologic Effects of Hyperoxia on the Lung in Rats
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Bahk JH, Kim SD
- KMID: 1934350
- Korean J Anesthesiol.
- 1995 Mar;28(3):330-337.
- doi: 10.4097/kjae.1995.28.3.330
An animal model was used to study the effects of normobaric hyperoxia on pulmonary mechanics and histopathology. Thirty two rats (227+/-46gm) were divided into control (Group 1) in room air... -
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- Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer
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Lee HY, Kim IK, Lee HI, Lee HY, Kang HS, Yeo CD, Kang HH, Moon HS, Lee SH
- KMID: 2411582
- Korean J Intern Med.
- 2018 May;33(3):541-551.
- doi: 10.3904/kjim.2016.334
BACKGROUND/AIMS: We explored the effects of intermittent normobaric hyperoxia alone or combined with chemotherapy on the growth, general morphology, oxidative stress, and apoptosis of benzo[a]pyrene (B[a]P)-induced lung tumors in mice. METHODS:... -
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- Changes in Pulmonary Interleukin-6 and Pulmonary Pathology in Neonatal Mice After Exposure to Hyperoxia and Ascorbate Treatment
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Chang HY, Park EH, Oh CH, Park MS, Namgung R, Park KI, Lee C, Han DG
- KMID: 1838666
- J Korean Soc Neonatol.
- 2001 May;8(1):103-109.
PURPOSE: Levels of proinflammatory cytokines such as IL-1, IL-6 and TNF-alpha have been shown to be increased in the lung of adult mice after exposure to hyperoxia. Ascorbate, a non-enzymatic... -
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- The Effect of Prenatal Dexamethasone Treatment on Pulmonary Antioxidant System in Newborn Rats during Prolonged High O2 Exposure
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Sung IK, Kim SY
- KMID: 2098993
- J Korean Soc Neonatol.
- 1999 Nov;6(2):178-185.
PURPOSE: To evaluate the effect of prenatally treated dexamethasone on pulmonary antioxidant enzyme system and survival rate in newborn rats during prolonged high oxygen exposure. METHODS: The wet lung weight/dry... -
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- Intratracheal Administration of Endotoxin Attenuates Hyperoxia-Induced Lung Injury in Neonatal Rats
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Shim JW, Chang YS, Park WS
- KMID: 2396098
- Yonsei Med J.
- 2008 Feb;49(1):144-150.
PURPOSE: This study was undertaken to determine the effects of intratracheal administration of endotoxin on hyperoxia-induced lung injury in neonatal rats. MATERIALS AND METHODS: Newborn Sprague Dawley rat pups were... -
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- Interleukin-10 Down-Regulates Cathepsin B Expression in Fetal Rat Alveolar Type II Cells Exposed to Hyperoxia
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Lee HS, Kim CK
- KMID: 1503909
- Yonsei Med J.
- 2013 Mar;54(2):445-452.
- doi: 10.3349/ymj.2013.54.2.445
PURPOSE: Hyperoxia has the chief biological effect of cell death. We have previously reported that cathepsin B (CB) is related to fetal alveolar type II cell (FATIIC) death and pretreatment... -
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- Morphologic Changes of Lung Parenchymal Tissue in Neonatal Rat Pups Under Chronic Hyperoxia
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Kim BI, Choi JH, Yun C
- KMID: 2208496
- J Korean Pediatr Soc.
- 1994 Aug;37(8):1055-1064.
We studied the effects of chronic hyperoxia (>95% oxygen for 14 days) in change of body weight, wet to dry lung weight ratio, and morphologic changes of lung tissue compared... -
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- The Effect of Hyperoxia on the Retinal and Optic Nerve Head Microcirculation in Smoke rs and Non-Smokers
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Kim SH, Kim HK, Kim HC
- KMID: 2336871
- J Korean Ophthalmol Soc.
- 1999 Jun;40(6):1568-1573.
The effect of hyperoxia and smoking on retinal and optic nerve head microcirculation, and O2 reactivity in smokers and non-smokers were investigated using HRF(Heidelberg Retinal Flowmeter). 10 eyes of 10... -
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- Erythropoietin Attenuates Hyperoxia-Induced Lung Injury by Down-modulating Inflammation in Neonatal Rats
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Lee JH, Sung DK, Koo SH, Shin BK, Hong YS, Son CS, Lee JW, Chang YS, Park WS
- KMID: 1785767
- J Korean Med Sci.
- 2007 Dec;22(6):1042-1047.
- doi: 10.3346/jkms.2007.22.6.1042
This study was done to determine whether recombinant human erythropoietin (rhEPO) treatment could attenuate hyperoxia-induced lung injury, and if so, whether this protective effect is mediated by the down-modulation of... -
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- The inflammatory response of neutrophils in an in vitro model that approximates the postcardiac arrest state
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Cho YD, Park SJ, Choi SH, Yoon YH, Kim JY, Lee SW, Lim CS
- KMID: 2392372
- Ann Surg Treat Res.
- 2017 Oct;93(4):217-224.
- doi: 10.4174/astr.2017.93.4.217
PURPOSE: Postcardiac arrest syndrome (PCAS) shares many features with sepsis including plasma cytokine elevation with dysregulation of cytokine production, and the presence of endotoxin in plasma. PCAS is closely related... -
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- The Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Alveolarization Inhibition Induced by Hyperoxia in Neonatal Rat
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Choi CW, Kim BI, Lim IS, Lee HJ, Joung KE, Shim GH, Lee JA, Kim EK, Kim HS, Choi JH
- KMID: 1750712
- J Korean Soc Neonatol.
- 2007 Nov;14(2):153-161.
PURPOSE: We sought to determine whether bone marrow-derived mesenchymal stem cells (BMMSC) could attenuate the inhibition of alveolarization induced by hyperoxia. METHODS: Human BMMSC (SNU-hMSC) were infused into the peritoneal cavity... -
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- Lipid Peroxidation in Vivo Monitored as Ethane Exhalation in Hyperoxia
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Song JC, Cho SH, Chung MH, Yun DR
- KMID: 2282269
- Korean J Prev Med.
- 1987 Nov;20(2):221-227.
In vivo ethane production in rats was used as an index of oxygen toxicity. The rats were allocated to four exposure conditions; hyperbaric oxygenation (HBO=5 ATA, 100% O2), normobaric oxygenation... -
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- A Study on The Effect of Hyperoxia on EKG Findings of Rabbits
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Lee SJ, Song JC, Park HB
- KMID: 2282587
- Korean J Prev Med.
- 1992 Mar;25(1):34-43.
To investigate the effect of hyperoxia on EKG findings and to evaluate the applicability of EKG as noninvasive monitoring index of oxygen toxicity, 38 rabbits were continuously exposed to 6... -
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- Hyperoxia influences mRNA expression of cytokines in cultured human umbilical vein endothelial cells
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Park MS, Wallace HM
- KMID: 711520
- Yonsei Med J.
- 1998 Feb;39(1):1-12.
- doi: 10.3349/ymj.1998.39.1.1
High concentrations of oxygen, indispensable for the treatment of severe hypoxemia from neonatal as well as adult respiratory distress syndrome, increase the risk of oxygen toxicity. Biochemical mechanisms are lipid... -
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- Time Course of Pulmonary Capillary Permeability Changes in the Rat Exposed to 100% Oxygen
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Bahk JH, Song H, Park SY, Kim SD
- KMID: 2237811
- Korean J Anesthesiol.
- 1996 Jan;30(1):15-19.
- doi: 10.4097/kjae.1996.30.1.15
BACKGROUND: Exposure to hyperoxia causes extensive injury to lung tissue, which resembles the pathologic changes of the adult respiratory distress syndrome. To observe the relationship between the pulmonary oxygen toxicity... -
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- Development of Immune Reaction Concept for Perinatology
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Kim HS
- KMID: 1896934
- Korean J Perinatol.
- 2015 Jun;26(2):109-113.
- doi: 10.14734/kjp.2015.26.2.109
Most of perinatological phenomenona and diseases are closely related with immune reaction. Most of initial immune responses occur through innate immunity and most causes, such as mechanical damage, hypoxia, and... -
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- Granulocyte Colony Stimulating Factor Attenuates Hyperoxia-Induced Lung Injury by Down-Modulating Inflammatory Responses in Neonatal Rats
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Jeon GW, Sung DK, Jung YJ, Koo SH, Choi SH, Chang YS, Sin JB, Park WS
- KMID: 1106439
- Yonsei Med J.
- 2011 Jan;52(1):65-73.
- doi: 10.3349/ymj.2011.52.1.65
PURPOSE: Granulocyte colony stimulating factor (G-CSF) has been known to increase neutrophil production and have anti-inflammatory properties, but the effect of G-CSF on pulmonary system is in controversy. We investigated... -
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