- On comparison of SAS codes with GLM and MIXED for the crossover studies with QT interval data
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Choi K, Hong T, Lee J
- KMID: 2050940
- Transl Clin Pharmacol.
- 2014 Dec;22(2):78-82.
- doi: 10.12793/tcp.2014.22.2.78
The structural complexity of crossover studies for bioequivalence test confuses analysts and leaves them a hard choice among various programs. Our study reviews PROC GLM and PROC MIXED in SAS... -
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- The Safety and Pharmacokinetics of Cyanidin-3-Glucoside after 2-Week Administration of Black Bean Seed Coat Extract in Healthy Subjects
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Jeon S, Han S, Lee J, Hong T, Yim DS
- KMID: 2011159
- Korean J Physiol Pharmacol.
- 2012 Aug;16(4):249-253.
- doi: 10.4196/kjpp.2012.16.4.249
We analyzed the pharmacokinetics of C3G on data from twelve subjects, after 2-week multiple dosing of black bean (Phaseolus vulgaris, Cheongjakong-3-ho) seed coat extract, using the mixed effect analysis method... -
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- Severe cerebral vasospasm following non-K1 Escherichia coli meningitis: a case report
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Stewart C, Hong T, Shobayo AA, Chang JE, Subramaniam T
- KMID: 2563029
- J Neurocrit Care.
- 2024 Dec;17(2):94-97.
- doi: 10.18700/jnc.240037
Background: Cerebral vasospasm has been reported following various forms of bacterial meningitis; however, there have been no prior reports of meningitis caused by the non-K1 strain of Escherichia coli. Case... -
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- A Review of Fundamentals of Statistical Concepts in Clinical Trials
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Choi K, Lee J, Jeon S, Hong T, Paek J, Han S, Yim DS
- KMID: 2334531
- J Korean Soc Clin Pharmacol Ther.
- 2012 Dec;20(2):109-124.
Statistical analysts engaged in typical clinical trials often have to confront a tight schedule to finish massive statistical analyses specified in a Standard Operation Procedure (SOP). Thus, statisticians or not,... -
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- Physiologically-based pharmacokinetic predictions of intestinal BCRP-mediated drug interactions of rosuvastatin in Koreans
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Bae SH, Park WS, Han S, Park GJ, Lee J, Hong T, Jeon S, Yim DS
- KMID: 2410096
- Korean J Physiol Pharmacol.
- 2018 May;22(3):321-329.
- doi: 10.4196/kjpp.2018.22.3.321
It was recently reported that the C(max) and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3,... -
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- Decreased potency of fimasartan in liver cirrhosis was quantified using mixed-effects analysis
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Kim CO, Jeon S, Han S, Hong T, Park MS, Yoon YR, Yim DS
- KMID: 2411418
- Transl Clin Pharmacol.
- 2017 Mar;25(1):43-51.
- doi: 10.12793/tcp.2017.25.1.43
Fimasartan is a nonpeptide angiotensin II receptor blocker. In a previous study that compared the pharmacokinetics (PK) of fimasartan between patients with hepatic impairment (cirrhosis) and healthy subjects, the exposure... -
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- Single institute experience of pancreatico-enteric anastomosis failure after pancreaticoduodenectomy
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Woo Y, You Y, Han J, Choi H, Kim Y, Kwak B, Hong T, Kim D
- KMID: 2452895
- Korean J Clin Oncol.
- 2019 Jun;15(1):19-26.
- doi: 10.14216/kjco.190019
PURPOSE: We have summarized the experience of our institution related to what treatment has been performed in patients with pancreatic fistula and their outcome. METHODS: Seventy-eight pancreatico-enteric anastomosis failure (PEAF) patients... -
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- Bone Marrow-Derived Mesenchymal Stem Cells Isolated from Patients with Cirrhosis and Healthy Volunteers Show Comparable Characteristics
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Lim YL, Eom YW, Park SJ, Hong T, Kang SH, Baik SK, Park KS, Kim MY
- KMID: 2508913
- Int J Stem Cells.
- 2020 Nov;13(3):394-403.
- doi: 10.15283/ijsc20072
Background and Objectives: Autologous or allogeneic bone marrow-derived mesenchymal stem cells (BMSCs) have been applied in clinical trials to treat liver disease. However, only a few studies are comparing the... -
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- High Resolution 3D Magnetic Resonance Fingerprinting with Hybrid Radial-Interleaved EPI Acquisition for Knee Cartilage T1 , T2 Mapping
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Han D, Hong T, Lee Y, Kim DH
- KMID: 2520438
- Investig Magn Reson Imaging.
- 2021 Sep;25(3):141-155.
- doi: 10.13104/imri.2021.25.3.141
Purpose: To develop a 3D magnetic resonance fingerprinting (MRF) method for application in high resolution knee cartilage PD, T1 , T2 mapping. Materials and Methods: A novel 3D acquisition trajectory with... -
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- Evaluation of pharmacokinetic interactions between amoxicillin, clarithromycin, and the potassium-competitive acid blocker YH4808 in healthy subjects
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Lee WY, Oh E, Cui M, Kim CO, Lim Y, Kim H, Park H, Yoon S, Park MS, Hong T
- KMID: 2505150
- Transl Clin Pharmacol.
- 2020 Mar;28(1):55-65.
- doi: 10.12793/tcp.2020.28.e5
YH4808 is a novel potassium-competitive acid blocker that was developed as a therapeutic agent for gastric acid-related diseases; it may replace proton pump inhibitors, which are widely used in combination... -
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- Pharmacokinetic drug interaction between atorvastatin and ezetimibe in healthy Korean volunteers
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Park J, Kim CO, Jin BH, Yang S, Park MS, Hong T
- KMID: 2407003
- Transl Clin Pharmacol.
- 2017 Dec;25(4):202-208.
- doi: 10.12793/tcp.2017.25.4.202
Atorvastatin and ezetimibe are frequently co-administered to treat patients with dyslipidemia for the purpose of low-density lipoprotein cholesterol control. However, pharmacokinetic (PK) drug interaction between atorvastatin and ezetimibe has not... -
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- Comparison of the Population Pharmacokinetics and Safety Between Please Orally Soluble Film and VIAGRA(R) in Healthy Male Volunteers
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Hong T, Lee J, Jeon S, Paek J, Kim HI, Kwak SS, Park SJ, Han S, Yim DS
- KMID: 2334542
- J Korean Soc Clin Pharmacol Ther.
- 2013 Jun;21(1):26-33.
BACKGROUND: The objective of this study was to compare the pharmacokinetics and safety between newly developed sildenafil (Please Orally Soluble Film) and sildenafil citrate (VIAGRA(R)) after single oral administration in... -
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- Effects of high occupational physical activity, aging, and exercise on heart rate variability among male workers
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Kang D, Kim Y, Kim J, Hwang Y, Cho B, Hong T, Sung B, Lee Y
- KMID: 2370868
- Ann Occup Environ Med.
- 2015 ;27(1):22.
- doi: 10.1186/s40557-015-0073-0
OBJECTIVES: Effects of aging and leisure time physical activity (LPA) might influence the effect of occupational physical activity (OPA) on risk for cardiovascular disease (CVD). This study was conducted to... -
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- Pharmacokinetics and Safety of Levodropropizine Controlled Release Tablet after Repeated Dosing in Healthy Male Volunteers
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Jeon S, Lee J, Hong T, Paek J, Han S, Yim DS
- KMID: 2203224
- J Korean Soc Clin Pharmacol Ther.
- 2013 Dec;21(2):113-119.
- doi: 10.12793/jkscpt.2013.21.2.113
BACKGROUND: Levodropropizine is non-opioid agent whose peripheral antitussive action may result from its modulation of sensory neuropeptide levels. Currently, levodropropizine 60 mg is taken three-times daily. A controlled release formulation... -
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- Immunogenicity and Safety of Trivalent Split Influenza Vaccine in Healthy Korean Adults with Low Pre-Existing Antibody Levels: An Open Phase I Trial
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Kang K, Han S, Hong T, Jeon S, Paek J, Kang JH, Yim DS
- KMID: 2427152
- Yonsei Med J.
- 2016 Nov;57(6):1354-1360.
- doi: 10.3349/ymj.2016.57.6.1354
PURPOSE: A phase I clinical trial was conducted to evaluate the immunogenicity and safety of newly developed egg-cultivated trivalent inactivated split influenza vaccine (TIV) in Korea. MATERIALS AND METHODS: The TIV... -
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