- Differential Mucin Gene Expression Associated with Methotrexate Resistance of Human Colonic Adenocarcinoma Cell Line, HT29
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Lee BH, Kim YS
- KMID: 2006789
- J Korean Cancer Assoc.
- 1997 Dec;29(6):977-983.
PURPOSE: In normal tissue, MUC2 mucin gene is expressed predominantly in goblet cells, while MUC3 is expressed in both goblet cells and columnar absorptive cells of small intestine and colon.... -
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- Activation of SAPK and increase in Bak levels during ceramide and indomethacin-induced apoptosis in HT29 cells
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Kim JH, Oh SO, Jun SS, Jung JS, Woo JS, Kim YK, Lee SH
- KMID: 1917073
- Korean J Physiol Pharmacol.
- 1999 Feb;3(1):75-82.
It has been reported that activation of sphingomyelin pathway and nonsteroidal anti-inflammatory drugs (NSAIDS) inhibit the promotion of colon carcinoma. Ceramide, a metabolite of sphingomyelin, and indomethacin were shown to induce apoptosis in... -
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- Usefulness of expression of protease as biologic marker in 5-FU resistant human colon cancer cell line HT29
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Cho M, Choi SR, Lee JI, Lee CJ, Kim YS
- KMID: 2251351
- Korean J Med.
- 1999 Sep;57(3):323-332.
There have been many reports that colon cancer responds poorly to chemotherapy. Several classes of matrix metalloproteinases(MMPs) have been implicated in the process of invasion of epithelial and endothelial basement membranes in... -
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- The Nedd8-activating enzyme inhibitor MLN4924 suppresses colon cancer cell growth via triggering autophagy
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Lv Y, Li B, Han K, Xiao Y, Yu X, Ma Y, Jiao Z, Gao J
- KMID: 2430084
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):617-625.
- doi: 10.4196/kjpp.2018.22.6.617
Neddylation is a post-translational protein modification process. MLN4924 is a newly discovered pharmaceutical neddylation inhibitor that suppresses cancer growth with several cancer types. In our study, we first investigated the... -
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- Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells
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Ndolo KM, Park KR, Lee HJ, Yoon KB, Kim YC, Han SY
- KMID: 2376868
- Immune Netw.
- 2017 Apr;17(2):110-115.
- doi: 10.4110/in.2017.17.2.110
Aurora kinase A plays an essential role in mitosis including chromosome separation and cytokinesis. Aberrant expression and activity of Aurora kinase A is associated with numerous malignancies including colorectal cancer... -
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- Sorbus rufopilosa Extract Exhibits Antioxidant and Anticancer Activities by Inducing Cell Cycle Arrest and Apoptosis in Human Colon Adenocarcinoma HT29 Cells
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Oh YN, Jin S, Park HJ, Kwon HJ, Kim BW
- KMID: 2367562
- J Cancer Prev.
- 2016 Dec;21(4):249-256.
- doi: 10.15430/JCP.2016.21.4.249
BACKGROUND: Sorbus rufopilosa, a tsema rowan, is a species of the small ornamental trees in the genus Sorbus and the family Rosaceae found in East Asia. The bioactivities of S.... -
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- The Effect of Lactobacillus acidophilus PTCC 1643 on Cultured Intestinal Epithelial Cells Infected with Salmonella enterica serovar Enteritidis
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Moshiri M, Dallal MM, Rezaei F, Douraghi M, Sharifi L, Noroozbabaei Z, Gholami M, Mirshafiey A
- KMID: 2386101
- Osong Public Health Res Perspect.
- 2017 Feb;8(1):54-60.
- doi: 10.24171/j.phrp.2017.8.1.07
OBJECTIVES: Gastrointestinal disorders caused by Salmonella enterica serovar Enteritidis (SesE) are a significant health problem around the globe. Probiotic bacteria have been shown to have positive effects on the immune... -
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- Cytotoxicity and Quinone Reductase Activity Stimulating Effects of Fin of Thunnus Thynnus Extracts in Various Cancer Cells
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Shin MO, Ku MJ, Bae SJ
- KMID: 2078410
- Korean J Nutr.
- 2007 Mar;40(2):147-153.
In this study, we investigated the anticancer activity of the fin of Thunnus Thynnus (TT ). TT was extracted with methanol (TTM ), and then further fractionated into four subfractions... -
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- Inhibitory effects of calcium against intestinal cancer in human colon cancer cells and ApcMin/+ mice
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Ju J, Kwak Y, Hao X, Yang CS
- KMID: 2313621
- Nutr Res Pract.
- 2012 Oct;6(5):396-404.
The aim of the study was to investigate the inhibitory effects of calcium against intestinal cancer in vitro and in vivo. We first investigated the effects of calcium treatment in... -
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- Cytosolic Glutathione S-Transferase Change after Deoxycholate Exposure in Colon Cancer Cell Lines
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Park DK, Shin JH, Park SG, Cheung SY
- KMID: 1835108
- J Korean Soc Coloproctol.
- 1998 Dec;14(4):701-708.
PURPOSE: Bile acids (especially deoxycholate) was known to be toxic and mutagenic on colon epithelium. They proposed at least four mechanisms for the bile acid toxicity. It is the one... -
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- Epigallocatechin-3-gallate Suppresses Galactose-alpha1,4-galactose-beta1,4-glucose Ceramide Expression in TNF-alpha Stimulated Human Intestinal Epithelial Cells Through Inhibition of MAPKs and NF-kappa B
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Moon DO, Choi SR, Lee CM, Kim GY, Lee HJ, Park YM
- KMID: 1712731
- J Korean Med Sci.
- 2005 Aug;20(4):548-554.
- doi: 10.3346/jkms.2005.20.4.548
Intestinal epithelial cells (IECs) have been known to produce galactose-alpha1,4-galactose-beta1,4-glucose ceramide (Gb3) that play an important role in the mucosal immune response. The regulation of Gb3 is important to prevent... -
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- Infection of human intestinal epithelial cells by invasive bacteria activates NF-κB and increases ICAM-1 expression through NOD1
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Shin WG, Park BJ, Lee SJ, Kim JG
- KMID: 2411512
- Korean J Intern Med.
- 2018 Jan;33(1):81-90.
- doi: 10.3904/kjim.2015.409
BACKGROUND/AIMS: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. Infection of human IECs with invasive bacteria... -
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- Nuclear Factor-kappa B Activation and Chemokine Genes Expression in HT-29 Intestinal Epithelial Cells in Response to Clostridium difficile Toxin A Stimulation
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Lee JY, Yoon YM, Roh HC, Kim JM
- KMID: 1574164
- J Bacteriol Virol.
- 2005 Sep;35(3):217-226.
Intestinal epithelial cells are known to up-regulate the expression of several chemokines in response to bacterial toxins. Since there has been little understanding on the cellular mechanisms of C. difficile... -
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- Expression of Cyclooxygenase - 2 in Intestinal Epithelial Cells in Response to Invasive Bacterial Infection and its Role of Epithelial Cell Apoptosis
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Kim JM, Kang SJ, Cho YJ
- KMID: 1543611
- J Korean Soc Microbiol.
- 1999 Oct;34(5):479-489.
Invasion of enteric bacteria, such as Salmonella and invasive E. coli, into intestinal epithelial cells induces proinflammatory gene responses and finally epithelial cell apoptosis. In this study, we asked whether... -
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- Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells
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Oh SY, Park KS, Kim AJ, Choi KY
- KMID: 1093594
- Exp Mol Med.
- 2002 Mar;34(1):27-31.
Activation of the extra cellular signal regulated kinase (ERK) pathway is involved in both proliferation and growth arrest of cells depending on intensity and duration of stimuli. In this study,... -
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- The Inhibitory Effect of Curcumin on the Growth of Human Colon Cancer Cells (HT-29, WiDr) in vitro
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Kim KH, Park HY, Nam JH, Park JE, Kim JY, Park MI, Chung KO, Park KY, Koo JY
- KMID: 772765
- Korean J Gastroenterol.
- 2005 Apr;45(4):277-284.
BACKGROUND/AIMS: The effects of curcumin on the growth of human colon cancer cell lines, HT-29 and WiDr cells were examined and the effects of 5-fluorouracil (5-FU) were also studied.... -
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- Effects of Contact Inhibitionof Entamoeba histolytica Trophozoites to Human Colon Epithelial Cells in Proinflammatory Cytokine Gene Expression in Colon Epithelial Cells Induced by E.histolytica
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Kim JM, Jung HC, Lee KM, Chin YJ, Kim YJ, Song IS, Kim CY
- KMID: 1772387
- Korean J Gastroenterol.
- 1997 Aug;30(2):194-203.
BACKGROUND AND AIMS: Entamoeba histolytica can cause invasive disease by clisruption of the intestinal barriers and subsequent lysis of the intestinal cells. Adherence to and contact-dependent killing of host cells... -
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- Involvement of Protein Kinase C delta in Iron Chelator-Induced IL-8 Production in Human Intestinal Epithelial Cells
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Sohn YW, Choi EY, Han WC, Yun KJ, Oh JM, Jun CD
- KMID: 2030768
- Korean J Anat.
- 2005 Feb;38(1):21-30.
Our previous study demonstrated that a bacterial siderophore, deferoxamine (DFO), could trigger inflammatory signals in human intestinal epithelial cells as a single stimulus, leading to IL-8 production via ERK1/2 and... -
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- Effect of Inonotus Obliques Extracts on Proliferation and Caspase-3 Activity in Human Castro-Intestinal Cancer Cell Lines
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Hwang YJ, Noh GW, Kim SH
- KMID: 2235853
- Korean J Nutr.
- 2003 Jan;36(1):18-23.
We studied the effects of hot water extract of Inonotus obliquos mushroom on the proliferation and apoptosis of the human colon adenocarcinoma, HT-29 and the human stomach adenocarcinoma, SNU-484 cell.... -
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- Effect of Lactacystin on the Sulindac-Induced Apoptosis Mechanisms in HT-29 Cells
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Kim JM, Park KJ, Kim SH, Choi HJ
- KMID: 2334296
- J Korean Soc Coloproctol.
- 2003 Apr;19(2):61-66.
PURPOSE: One of possible mechanisms of the antineoplastic effect by nonsteroidal anti-inflammatory drugs (NSAIDs) is an induction of apoptosis. The NSAIDs-induced apoptosis appears to be caspase- and mitochondria-dependent. The ubiquitin-proteasome... -
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