- Knockdown of 14-3-3zeta enhances radiosensitivity and radio-induced apoptosis in CD133+ liver cancer stem cells
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Lee YK, Hur W, Lee SW, Hong SW, Kim SW, Choi JE, Yoon SK
- KMID: 2155342
- Exp Mol Med.
- 2014 Feb;46(2):e77.
- doi: 10.1038/emm.2013.151
14-3-3zeta is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3zeta decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study,... -
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- TIGR gene in primary open-angle glaucoma and steroid-induced glaucoma
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Kee C, Ahn BH
- KMID: 1375118
- Korean J Ophthalmol.
- 1997 Dec;11(2):75-78.
- doi: 10.3341/kjo.1997.11.2.75
To identify TIGR gene mutation in two Korean pedigrees of primary open-angle glaucoma (POAG), and in 25 steroid-induced glaucoma patients, TIGR gene assay was performed. Genomic DNA was extracted from... -
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- A Case of 9.7 Mb Terminal Xp Deletion Including OA1 Locus Associated with Contiguous Gene Syndrome
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Cho EH, Kim SY, Kim JK
- KMID: 1778839
- J Korean Med Sci.
- 2012 Oct;27(10):1273-1277.
- doi: 10.3346/jkms.2012.27.10.1273
Terminal or interstitial deletions of Xp (Xp22.2-->Xpter) in males have been recognized as a cause of contiguous gene syndromes showing variable association of apparently unrelated clinical manifestations such as Leri-Weill... -
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- Two Siblings with Adolescent/Adult Onset Niemann-Pick Disease Type C in Korea
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Lee SY, Lee HJ, Kim SH, Jeong YJ, Jin HK, Bae JS, Cheon SM, Kim JW
- KMID: 2373740
- J Korean Med Sci.
- 2016 Jul;31(7):1168-1172.
- doi: 10.3346/jkms.2016.31.7.1168
Niemann-Pick disease, type C (NP-C), is caused by NPC1 or NPC2 gene mutations. Progressive neurological, psychiatric, and visceral symptoms are characteristic. Here, we present cases of a brother (Case 1)... -
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- Field Cancerization in Sporadic Colon Cancer
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Park SK, Song CS, Yang HJ, Jung YS, Choi KY, Koo DH, Kim KE, Jeong KU, Kim HO, Kim H, Chun HK, Park DI
- KMID: 2412075
- Gut Liver.
- 2016 Sep;10(5):773-780.
- doi: 10.5009/gnl15334
BACKGROUND/AIMS: Aberrant DNA methylation has a specific role in field cancerization. Certain molecular markers, including secreted frizzled-related protein 2 (SFRP2), tissue factor pathway inhibitor 2 (TFPI2), N-Myc downstream-regulated gene 4... -
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- Human Brain Astrocytes Mediate TRAIL-mediated Apoptosis after Treatment with IFN-gamma
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Lee J, Shin JS, Choi IH
- KMID: 1715853
- Yonsei Med J.
- 2006 Jun;47(3):354-358.
- doi: 10.3349/ymj.2006.47.3.354
TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1beta TNF-alphaor IFN-gamma TRAIL was induced in... -
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- Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: Involvement of RTP801 in amyloid beta-peptide toxicity
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Kim JR, Lee SR, Chung HJ, Kim S, Baek SH, Kim JH, Kim YS
- KMID: 1093613
- Exp Mol Med.
- 2003 Oct;35(5):403-411.
Amyloid beta-peptide (Abeta), a causative molecule in the pathogenesis of Alzheimer's disease and the main component of senile plaques, is known to be neurotoxic in vitro and in vivo. The... -
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- The Combination of TRAIL Treatment and Cancer Cell Selective Expression of TRAIL-Death Receptor DR4 Induces Cell Death in TRAIL-Resistant Cancer Cells
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Choi E, Kim Y, Kim K
- KMID: 1715873
- Yonsei Med J.
- 2006 Feb;47(1):55-62.
- doi: 10.3349/ymj.2006.47.1.55
The human telomerase reverse transcriptase (hTERT) promoter can be used for the tumor-specific expression of transgenes in order to induce selective cancer cell death. The hTERT core promoter is active... -
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- Cloning of adriamycin-resistant related (arr) gene in an adriamycin-resistant L1210 variant
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Kim JR, Kim SY, Kim JH
- KMID: 1109297
- Exp Mol Med.
- 1998 Sep;30(3):145-149.
A partial fragment of novel sequence (arr, adriamycin-resistant related) was previously identified using the differential display (DD)-PCR technique with adriamycin-resistant L1210 variant (L1210AdR), which shows a typical multidrug resistant (MDR)... -
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- Molecular characterization of Korean rabies virus isolates
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Yang DK, Park YN, Hong GS, Kang HK, Oh YI, Cho SD, Song JY
- KMID: 1067338
- J Vet Sci.
- 2011 Mar;12(1):57-63.
- doi: 10.4142/jvs.2011.12.1.57
The nucleoprotein (N) and glycoprotein (G) of 11 Korean rabies virus (RABV) isolates collected from animals diagnosed with rabies between 2008 and 2009 were subjected to molecular and phylogenetic analyses.... -
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- Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1
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Kwak HB, Yang D, Ha H, Lee JH, Kim HN, Woo ER, Lee S, Kim HH, Lee ZH
- KMID: 1094151
- Exp Mol Med.
- 2006 Jun;38(3):256-264.
Bone is a dynamic tissue that is regulated by the activity of bone-resorbing osteoclasts and bone-forming osteoblasts. Excessive osteoclast formation causes diseases such as osteoporosis and rheumatoid arthritis. Natural substances... -
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- Expression of Mucin Genes in the Human Testis and Its Relationship to Spermatogenesis
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Seo JT, Lee JS, Jun JH, Yang MH
- KMID: 2158147
- Yonsei Med J.
- 2005 Oct;46(5):667-672.
- doi: 10.3349/ymj.2005.46.5.667
In this study we investigate the expression pattern of mucin genes in the human testis and evaluate the relationship between the expression of mucin genes and impaired spermatogenesis in the... -
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- Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathway
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Jee B, Jin K, Hahn JH, Song HG, Lee H
- KMID: 1088655
- Exp Mol Med.
- 2003 Feb;35(1):30-37.
To investigate the functional role of KAI1/CD82, a metastasis suppressor for human prostate cancer, in the regulation of homotypic cell adhesion, we transfected KAI1 cDNA into DU 145 human prostate... -
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- Biomedical significance of endothelial cell specific growth factor, angiopoietin
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Koh GY, Kim I, Kwak HJ, Yun MJ, Leem JC
- KMID: 1093591
- Exp Mol Med.
- 2002 Mar;34(1):1-11.
Until recently, vascular endothelial growth factor (VEGF) was the only growth factor proven to be specific and critical for blood vessel formation. Other long-known factors, such as the fibroblast growth... -
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- FKBP-12 Exhibits an Inhibitory Activity on Calcium Oxalate Crystal Growth in Vitro
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Han IS, Nakagawa Y, Park JW, Suh MH, Suh SI, Shin SW, Ahn SY, Choe BK
- KMID: 2157592
- J Korean Med Sci.
- 2002 Feb;17(1):41-48.
- doi: 10.3346/jkms.2002.17.1.41
Urolithiasis and calcium oxalate crystal deposition diseases are still significant medical problems. In the course of nephrocalcin cDNA cloning, we have identified FKBP-12 as an inhibitory molecule of calcium oxalate... -
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- An antioxidant modulates expression of receptor activator of NF-kappaB in asthma
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Lee KS, Park HS, Park SJ, Kim SR, Min KH, Jin SM, Li L, Lee YC
- KMID: 1094147
- Exp Mol Med.
- 2006 Jun;38(3):217-229.
Oxidative stress plays critical roles in airway inflammation that is usually accompanied by increased vascular permeability and plasma exudation. VEGF increases vascular permeability and leads to airway inflammation. In addition,... -
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- Role of STAT3 as a Negative Regulator in Mac2- Binding Protein Expression
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Park YP, Kim JT, Yang Y, Lim JS, Yoon DY, Kim JW, Lee HG
- KMID: 854872
- Korean J Lab Med.
- 2008 Jun;28(3):230-238.
- doi: 10.3343/kjlm.2008.28.3.230
BACKGROUND: Mac-2 binding protein (Mac-2BP) is a secreted glycoprotein from the culture fluid of several human cancer cells, especially breast, lung, and gastric cells. Mac-2BP plays a role in immune... -
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