- Rhox in mammalian reproduction and development
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Lee SE, Lee SY, Lee KA
- KMID: 2167500
- Clin Exp Reprod Med.
- 2013 Sep;40(3):107-114.
- doi: 10.5653/cerm.2013.40.3.107
Homeobox genes play essential roles in embryonic development and reproduction. Recently, a large cluster of homeobox genes, reproductive homeobox genes on the X chromosome (Rhox) genes, was discovered as three... -
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- Expression pattern of the class I homeobox genes in ovarian carcinoma
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Hong JH, Lee JK, Park JJ, Lee NW, Lee KW, Na JY
- KMID: 2173508
- J Gynecol Oncol.
- 2010 Mar;21(1):29-37.
- doi: 10.3802/jgo.2010.21.1.29
OBJECTIVE: Although some sporadic reports reveal the link between the homeobox (HOX) genes and ovarian carcinoma, there is no comprehensive analysis of the expression pattern of the class I homeobox... -
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- Lin28 regulates the expression of neuropeptide Y receptors and oocyte-specific homeobox genes in mouse embryonic stem cells
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Park GT, Seo YM, Lee SY, Lee KA
- KMID: 1743696
- Clin Exp Reprod Med.
- 2012 Jun;39(2):87-93.
- doi: 10.5653/cerm.2012.39.2.87
OBJECTIVE: Lin28 has been known to control the proliferation and pluripotency of embryonic stem cells. The purpose of this study was to determine the downstream effectors of Lin28 in mouse... -
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- Expression and Cellular Localization of Psx Gene in Rat Placenta
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Choi EH, Jung C, Nam KI, Lee SW, Bae CS, Kim BY, Park SS, Ahn KY
- KMID: 1982474
- Korean J Phys Anthropol.
- 2011 Mar;24(1):51-56.
Homeobox genes seem to play critical roles in regulating morphogenesis, patterning, organogenesis, and differentiation. They have the conserved sequence that codes the DNA-binding domain called homeodomain. The expression and cellular... -
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- A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)
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Moon Y, Horsman DE, Humphries , Park G
- KMID: 1493618
- Immune Netw.
- 2013 Oct;13(5):222-226.
- doi: 10.4110/in.2013.13.5.222
Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation... -
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- Nuclear localization of Obox4 is dependent on its homeobox domain
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Park GT, Lee KA
- KMID: 1430076
- Clin Exp Reprod Med.
- 2013 Mar;40(1):1-6.
- doi: 10.5653/cerm.2013.40.1.1
OBJECTIVE: Oocyte-specific homeobox 4 (Obox4) is preferentially expressed in oocytes and plays an important role in the completion of meiosis of oocytes. However, the Obox4 expression pattern has not been... -
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- HOXC10 suppresses browning of white adipose tissues
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Ng Y, Tan SX, Chia SY, Tan HY, Gun SY, Sun L, Hong W, Han W
- KMID: 2375022
- Exp Mol Med.
- 2017 Feb;49(2):e292.
- doi: 10.1038/emm.2016.144
Given that increased thermogenesis in white adipose tissue, also known as browning, promotes energy expenditure, significant efforts have been invested to determine the molecular factors involved in this process. Here... -
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- A Case of Idiopathic Central Diabetes Insipidus together with Primary Empty Sella and Combined Pituitary Hormone Deficiency
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Ahn SY, Bae KH, Kim MH, Lee JH, Shon HS, Jung ED
- KMID: 2063537
- J Korean Endocr Soc.
- 2007 Aug;22(4):272-276.
- doi: 10.3803/jkes.2007.22.4.272
Central diabetes insipidus is a heterogeneous condition that is characterized by polyuria and polydipsia, and this is due to a deficiency of arginine vasopressin. Central diabetes insipidus is rare in... -
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- A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature
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Jung HY, Cho H, Chung JH, Bae SB, Lee JH, Lee HJ, Jang SH, Oh MH
- KMID: 2151143
- J Pathol Transl Med.
- 2015 Jul;49(4):331-334.
- doi: 10.4132/jptm.2015.04.16
Thymic carcinomas are uncommon malignant tumors, and thymic adenocarcinomas are extremely rare. Here, we describe a case of primary thymic adenocarcinoma in a 59-year-old woman. Histological examination of the tumor... -
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- Dlx3 and Dlx5 Inhibit Adipogenic Differentiation of Human Dental Pulp Stem Cells
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Lee HL, Nam H, Lee G, Baek JH
- KMID: 2009497
- Int J Oral Biol.
- 2012 Mar;37(1):31-36.
Dlx3 and Dlx5 are homeobox domain proteins and are well-known regulators of osteoblastic differentiation. Since possible reciprocal relationships between osteogenic and adipogenic differentiation in mesenchymal stem cells exist, we examined... -
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- A Case of Septo-optic Dysplasia Associated with Anterior Pituitary Hormone Abnormalities
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Lee JW, Hwang EK, Kim TH, Yoon HY, Jung JH, Choi YW, Yong SW, Ahn JH, Kim SY, Kim HS, Chung YS
- KMID: 1468493
- J Korean Endocr Soc.
- 2009 Mar;24(1):33-37.
- doi: 10.3803/jkes.2009.24.1.33
Septo-optic dysplasia (SOD) is a rare congenital malformation syndrome that is manifested by a triad of optic nerve hypoplasia, midline brain abnormalities and hypopituitarism. It is known to be associated... -
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- DNA-Based Identification of Necrophagous Fly Species Using Abdominal-B (Abd-B) Homeobox Sequence
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Piao HG, Chung U, Shin SE, Ko KS, Hwang JJ
- KMID: 2250322
- Korean J Leg Med.
- 2012 May;36(1):74-84.
- doi: 10.7580/KoreanJLegMed.2012.36.1.74
In medicolegal investigations, correct identification of the necrophagous fly species collected around and on the corpse is an essential step for estimating the postmortem interval (PMI). Therefore, forensic pathologists and... -
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- Promoter methylation and expression levels of selected hematopoietic genes in pediatric B-cell acute lymphoblastic leukemia
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Musialik E, Bujko M, Kober P, Wypych A, Gawle-Krawczyk K, Matysiak M, Siedlecki
- KMID: 1787909
- Blood Res.
- 2015 Mar;50(1):26-32.
- doi: 10.5045/br.2015.50.1.26
BACKGROUND: Precursor B-cell acute lymphoblastic leukemia (B-cell ALL) is the most common neoplasm in children and is characterized by genetic and epigenetic aberrations in hematopoietic transcription factor (TF) genes. This... -
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- The Mechanism of White and Brown Adipocyte Differentiation
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Nakagami H
- KMID: 2280709
- Diabetes Metab J.
- 2013 Apr;37(2):85-90.
- doi: 10.4093/dmj.2013.37.2.85
Obesity gives vent to many diseases such as type 2 diabetes, hypertension, and hyperlipidemia, being considered as the main causes of mortality and morbidity worldwide. The pathogenesis and pathophysiology of... -
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- Relationship of CDX1 mRNA and CDX2 mRNA expression and clinicopathologic features in colorectal cancers
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Kim GH, Lee DH, Kim HW, Cheong JY, Seo SB, Heo J, Kang DH, Song GA, Cho M, Yang US, Park DY, Yoo MA
- KMID: 2306008
- Korean J Med.
- 2004 Oct;67(4):349-357.
BACKGROUND: CDX1 and CDX2, members of the caudal-type homeobox gene family, control proliferation and differentiation of intestinal mucosal cells. Their expression is reduced commonly in colorectal cancers, but reports about... -
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- Chromatin organization and transcriptional activation of Hox genes
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Lee JY, Min H, Wang X, Khan AA, Kim MH
- KMID: 2168900
- Anat Cell Biol.
- 2010 Mar;43(1):78-85.
- doi: 10.5115/acb.2010.43.1.78
Spatially and temporally programmed expression of the Hox genes along the antero-posterior (A-P) axis is essential for correct pattern formation during embryonic development. An accumulating body of evidence indicates the... -
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- Decreased Expression and Induced Nucleocytoplasmic Translocation of Pancreatic and Duodenal Homeobox 1 in INS-1 Cells Exposed to High Glucose and Palmitate
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Ryu GR, Yoo JM, Lee E, Ko SH, Ahn YB, Song KH
- KMID: 2281494
- Diabetes Metab J.
- 2011 Feb;35(1):65-71.
- doi: 10.4093/dmj.2011.35.1.65
BACKGROUND: Type 2 diabetes mellitus (T2DM) is often accompanied by increased levels of circulating fatty acid. Elevations in fatty acids and glucose for prolonged periods of time have been suggested... -
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- Underexpression of HOXA11 Is Associated with Treatment Resistance and Poor Prognosis in Glioblastoma
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Se YB, Kim SH, Kim JY, Kim JE, Dho YS, Kim JW, Kim YH, Woo HG, Kim SH, Kang SH, Kim HJ, Kim TM, Lee ST, Choi SH, Park SH, Kim IH, Kim DG, Park CK
- KMID: 2378110
- Cancer Res Treat.
- 2017 Apr;49(2):387-398.
- doi: 10.4143/crt.2016.106
PURPOSE: Homeobox (HOX) genes are essential developmental regulators that should normally be in the silenced state in an adult brain. The aberrant expression of HOX genes has been associated with... -
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- The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation
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Yeo CD, Kang N, Choi SY, Kim BN, Park CK, Kim JW, Kim YK, Kim SJ
- KMID: 2387703
- Korean J Intern Med.
- 2017 Jul;32(4):589-599.
- doi: 10.3904/kjim.2016.302
A hypoxic microenvironment leads to cancer progression and increases the metastatic potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. The hypoxic response pathway can... -
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- Currarino triad with Mullerian duct anomaly in mother and daughter without MNX1 gene mutation
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Kim SH, Paek SH, Kim HY, Jung SE, Park KW
- KMID: 2149932
- Ann Surg Treat Res.
- 2016 Jan;90(1):49-52.
- doi: 10.4174/astr.2016.90.1.49
The Currarino triad is a unique complex of congenital caudal anomalies, including anorectal malformation, sacral bony defect and presacral mass. This triad may be associated with Mullerian duct anomalies, such... -
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