Exp Mol Med.  2017 Feb;49(2):e292. 10.1038/emm.2016.144.

HOXC10 suppresses browning of white adipose tissues

Affiliations
  • 1Metabolism in Human Diseases Unit, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. Weiping_Han@sbic.a-star.edu.sg
  • 2Cardiovascular and Metabolic Disorder Program, Duke-NUS Graduate Medical School, Singapore, Singapore.
  • 3Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Abstract

Given that increased thermogenesis in white adipose tissue, also known as browning, promotes energy expenditure, significant efforts have been invested to determine the molecular factors involved in this process. Here we show that HOXC10, a homeobox domain-containing transcription factor expressed in subcutaneous white adipose tissue, is a suppressor of genes involved in browning white adipose tissue. Ectopic expression of HOXC10 in adipocytes suppresses brown fat genes, whereas the depletion of HOXC10 in adipocytes and myoblasts increases the expression of brown fat genes. The protein level of HOXC10 inversely correlates with brown fat genes in subcutaneous white adipose tissue of cold-exposed mice. Expression of HOXC10 in mice suppresses cold-induced browning in subcutaneous white adipose tissue and abolishes the beneficial effect of cold exposure on glucose clearance. HOXC10 exerts its effect, at least in part, by suppressing PRDM16 expression. The results support that HOXC10 is a key negative regulator of the process of browning in white adipose tissue.


MeSH Terms

Adipocytes
Adipose Tissue, Brown
Adipose Tissue, White
Animals
Ectopic Gene Expression
Energy Metabolism
Genes, Homeobox
Glucose
Mice
Myoblasts
Thermogenesis
Transcription Factors
Glucose
Transcription Factors
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