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BACKGROUND: Melanocortin-1 receptor (Mc1r), a key signaling receptor for melanogenesis, has been reported to mediate migration of B16F10 melanoma cells. Interestingly, this activity appears to be a part of the...
The homologous regulation of pituitary Gonadotropin Releasing Hormone Receptor (GnRH-R) mRNA expression by GnRH has been well demonstrated. However, the regulation of the ovarian GnRH-R is poorly...
PURPOSE: The biologic behavior of tumor cells is partially controlled by the microenvironment.
We investigated the expression levels of several genes involved in metastasis and drug response
in RENCA cells growing in...
Previously it has been shown that persistent activation of the stimulatory
adenylyl cyclase pathway with cholera toxin (CT) downregulates the Gs alpha
polypeptide (80%) in a cAMP-independent manner in C6 glioma cells...
Two intracellular signal pathways mediated by cAMP and protein kinase C (PKC)
were involved in the regulation of FN gene expression (Lee et al., Exp. Mol.
Med. 30: 240, 1998). In this...
We studied the regulation of fibronectin (FN) gene expression by cAMP and
phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells.
Dibutyryl cAMP increased FN synthesis and mRNA levels, while PMA inhibited...