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Novel foot-and-mouth disease virus in Korea, July-August 2014

Park JH, Tark D, Lee KN, Lee SY, Ko MK, Lee HS, Kim SM, Ko YJ, Seo MG, Chun JE, Lee MH, Kim B

Despite nation-wide immunization with O, A, and Asia 1 type vaccines in Republic of Korea, foot-and-mouth disease type O occurred again in July 2014 after three years and three months....
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A reverse transcription loop-mediated isothermal amplification assay to rapidly diagnose foot-and-mouth disease virus C

Ding YZ, Zhou JH, Ma LN, Qi YN, Wei G, Zhang J, Zhang YG

A reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay was developed to rapidly detect foot-and-mouth disease virus serotype C (FMDV C). By testing 10-fold serial dilutions of FMDV C samples, sensitivity...
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Establishment of optimal disinfection condition of weak acid hypochlorous solution for prevention of avian influenza and foot-and-mouth disease virus transmission

Kim JY, Yun DS, Lee HY, Jeong WS, Park SC

This study examined the disinfection conditions (exposure time, 0–30 min; exposure temperature, 4℃–65℃) of hypochlorous acid water (HOCl) in automobile disinfection equipment. The study tested poliovirus type 1 (PV1), low...
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The expressions of HSP70 and alphaB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs

Gulbahar M, Kabak YB, Karayigit , Yarim M, Guvenc T, Parlak U

This study describes the expression of heat shock protein70 (HSP70) and alpha-basic-crystallin (alpha-BC) and their association with apoptosis and some related adaptor proteins in the pathogenesis of foot-and-mouth disease virus...
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Stable Expression of Bovine Integrin Beta-6 Increases Susceptibility of Goat Kidney Cell Line to Foot-and-mouth Disease Virus

Kim SM, Kim SK, Lee KN, Park JH, Kim B

The integrins αvβ1, αvβ3, αvβ6, and αvβ8 are known to be the natural receptors of foot-and-mouth disease virus (FMDV). Among them, integrin αvβ6 is considered a major receptor for FMDV....
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Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain

Kim RH, Chu JQ, Park JN, Lee SY, Lee YJ, Ko MK, Hwang JH, Lee KN, Kim SM, Tark D, Ko YJ, Lee HS, Seo MG, Park ME, Kim B, Park JH

We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of...
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Dietary germanium biotite supplementation enhances the induction of antibody responses to foot-and-mouth disease virus vaccine in pigs

Lee JA, Jung BG, Jung M, Kim TH, Yoo HS, Lee BJ

We evaluated the potential ability of germanium biotite (GB) to stimulate the production of antibodies specific for foot-and-mouth disease virus (FMDV). To this aim, we measured the total FMDV-specific antibody...
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Increased humoral antibody response of foot-and-mouth disease virus vaccine in growing pigs pre-treated with poly-γ-glutamic acid

Lee JH, Kang IJ, Kim AR, Noh YS, Chung HC, Park BK

This study was conducted to determine if humoral antibody response of foot-and-mouth disease (FMD) vaccine improved in 8-week-old growing pigs born to well-vaccinated sows pre-treated with 60 mg of poly-γ-glutamic...
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Conditions for the disinfectant efficacy test under subzero temperatures

Chae WS, Jeong W, Lee HJ

To establish appropriate conditions for a disinfectant efficacy test at subzero temperatures, this study examined mixtures of frozen foot-and-mouth disease virus or avian influenza virus solutions and disinfectant diluents at...
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Synthetic and Adenovirus Delivered Small Interference RNA Pools Targeting Conserved Regions of Foot-and-Mouth Disease Virus

Kim SM, Lee KN, Ko YJ, Joo YS, Kim HS, Park JH

Foot-and-mouth disease (FMD) is an economically significant animal disease because of the speed of its transmission. Routine vaccination may not be effective for early protection in an outbreak situation. Small...
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Influence of vaccine potency and booster administration of foot-and-mouth disease vaccines on the antibody response in calves with maternal antibodies

Çokçalışkan C, Türkoğlu T, Uzunlu E, Sareyyüpoğlu B, Hancı I, İpek A, Arslan A, Babak A, İldeniz G, Gülyaz V

Foot-and-mouth disease is one of the most important viral diseases of cloven-hoofed animals. Mass vaccination is an effective method to control the disease and is frequently utilized in endemic regions....
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Genetic identification and serological evaluation of commercial inactivated foot-and-mouth disease virus vaccine in pigs

Je SH, Kwon T, Yoo SJ, Lee DU, Seo SW, Byun JJ, Shin JY, Lyoo YS

Vaccination is considered a frequently used tool to prevent and control foot-and-mouth disease (FMD). However, the effectiveness of conventional FMD virus (FMDV) vaccines in pigs has been controversial because the...
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Establishment and evaluation of a murine alphavbeta3-integrin-expressing cell line with increased susceptibility to Foot-and-mouth disease virus

Zhang W, Lian K, Yang F, Yang Y, Zhu Z, Zhu Z, Cao W, Mao R, Jin Y, He J, Guo J, Liu X, Zheng H

Integrin alphavbeta3 plays a major role in various signaling pathways, cell apoptosis, and tumor angiogenesis. To examine the functions and roles of alphavbeta3 integrin, a stable CHO-677 cell line expressing...
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Development of synthetic peptide ELISA based on nonstructural protein 2C of foot and mouth disease virus

Oem JK, Kye SJ, Lee KN, Park JH, Kim YJ, Song HJ, Yeh M

  • KMID: 1090767
  • J Vet Sci.
  • 2005 Dec;6(4):317-325.
It was reported that the sera of convalescent animals contain antibodies to foot and mouth disease (FMD) virus (FMDV) 2C, highly conserved nonstructural protein (NSP), whereas the sera of vaccinated...
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Targeted Delivery of VP1 Antigen of Foot-and-mouth Disease Virus to M Cells Enhances the Antigen-specific Systemic and Mucosal Immune Response

Kim SH, Lee HY, Jang YS

Application of vaccine materials through oral mucosal route confers great economical advantage in animal farming industry due to much less vaccination cost compared with that of injection-based vaccination. In particular,...
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Evaluation of infectivity and transmission of different Asian foot-and-mouth disease viruses in swine

Pacheco JM, Mason PW

Most isolates of foot-and-mouth disease virus (FMDV) display a broad host range. Since the late 1990s, the genetic lineage of PanAsia topotype FMDV serotype O has caused epidemics in the...
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Enhanced immune response with foot and mouth disease virus VP1 and interleukin-1 fusion genes

Park JH, Kim SJ, Oem JK, Lee KN, Kim YJ, Kye SJ, Park JY, Joo YS

The capsid of the foot and mouth disease (FMD) virus carries the epitopes that are critical for inducing the immune response. In an attempt to enhance the specific immune response,...
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Development of a Lightcycler-based reverse transcription polymerase chain reaction for the detection of foot-and-mouth disease virus

Oem JK, Kye SJ, Lee KN, Kim YJ, Park JY, Park JH, Joo YS, Song HJ

  • KMID: 1091201
  • J Vet Sci.
  • 2005 Sep;6(3):207-212.
One step TaqMan real-time reverse transcription polymerase chain reaction (R/T RT-PCR)using a set of primers/probes was developed for the detection of foot-and-mouth disease (FMD)virus. The gene-specific probes labeled fluorogen for...
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Identification and antigenic site analysis of foot-and-mouth disease virus from pigs and cattle in Korea

Oem JK, Lee KN, Cho IS, Kye SJ, Park JY, Park JH, Kim YJ, Joo YS, Song HJ

  • KMID: 1114852
  • J Vet Sci.
  • 2005 Jun;6(2):117-124.
From May to June 2002, a total of 16 foot-and mouth disease (FMD) outbreaks due to the serotype O virus, Pan Asia strain, were recorded in Korea. The viruses were...
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Comparative study of codon substitution patterns in foot-and-mouth disease virus (serotype O)

Ahn I, Bae SE, Son HS

We compared genetic variations in the VP1 gene of foot-and-mouth disease viruses (FMDVs) isolated since 2000 from various region of the world. We analyzed relative synonymous codon usage (RSCU) and...
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