Clin Exp Vaccine Res.  2015 Jan;4(1):114-118. 10.7774/cevr.2015.4.1.114.

Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain

Affiliations
  • 1Animal and Plant Quarantine Agency, Anyang, Korea. parkjhvet@korea.kr
  • 2Clinical Research Center of the Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.

Abstract

We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in the pigs, dairy goats or suckling mice, but neutralizing antibodies were raised 5-6 days after the virus challenge. The utilization of O Manisa as a safe vaccine strain will increase if recombinant viruses can be manipulated by inserting or removing a marker gene for differential serology or replacing the protective gene from another serotype.

Keyword

Foot-and-mouth disease; Vaccine; Molecular cloning

MeSH Terms

Animals
Antibodies, Neutralizing
Clone Cells*
Cloning, Molecular
DNA, Complementary*
Foot-and-Mouth Disease
Foot-and-Mouth Disease Virus*
Goats
Humans
Mice
Parents
Swine
Virulence*
Antibodies, Neutralizing
DNA, Complementary
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