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Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial

Woo SD, Ye YM, Lee Y, Lee SH, Shin YS, Park JH, Choi H, Lee HY, Shin HJ, Park HS

PURPOSE: Asthma control in older asthmatics is often less effective, which may be attributed to small airway dysfunction and poor inhalation technique. We compared the efficacy of 2 inhalers (fluticasone...
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The Effects of Olfactory Training with Intranasal Corticosteroid Spray in Korean Patients with Olfactory Dysfunction

Jung YD, Kim DS, Kang BJ, Shin SH, Ye MK

BACKGROUND AND OBJECTIVES: Olfactory training is an alternative treatment based on modulation of the regeneration process of the olfactory system via repeated exposure to odors. Our study aimed to investigate...
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Efficacy and predictors of response to inhaled corticosteroid treatment for chronic cough

Hong JY, Kim JH, Park S, Hwang YI, Jung KS, Jang SH

BACKGROUND/AIMS: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial. METHODS: We conducted a prospective observational study...
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Pharmacokinetic characteristics of fluticasone, salmeterol and tiotropium after concurrent inhalation

Sunwoo J, Rhee SJ, Lee S, Lee SW, Jung J, Son H, Jang IJ

Chronic obstructive pulmonary disease (COPD) is a type of progressive, obstructive lung disease characterized by long-term poor airflow. The symptoms of COPD may be relieved and its progression delayed by...
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Assessment of leukotriene E4 in exhaled breath condensate as a marker of inflammation and therapeutic effect in allergic rhinitis children

Kwak BO, Park YM

PURPOSE: Recent studies have shown that the cysteinyl leukotriene (cysLT) of exhaled breath condensate (EBC) could be predictive of inflammatory status and effectiveness of treatment in allergic disease. The aim...
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Different anti-remodeling effect of nilotinib and fluticasone in a chronic asthma model

Kang HS, Rhee CK, Lee HY, Yoon HK, Kwon SS, Lee SY

BACKGROUND/AIMS: Inhaled corticosteroids are the most effective treatment currently available for asthma, but their beneficial effect against airway remodeling is limited. The tyrosine kinase inhibitor nilotinib has inhibitory activity against...
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Three-month Treatment Response and Exacerbation in Chronic Obstructive Pulmonary Disease

Lee JS, Rhee CK, Yoo KH, Lee JH, Yoon HI, Kim TH, Kim WJ, Lee J, Lim SY, Park TS, Lee JS, Lee SW, Lee SD, Oh YM

The aim of this study was to investigate relationships between acute exacerbation and Forced Expiratory Volume 1 second (FEV1) improvement after treatment with combined long-acting beta-agonist (LABA) and inhaled corticosteroid...
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Suppressive effects of long-term treatment with inhaled steroids on hypothalamic-pituitary-adrenal axis in asthma

Sim DW, Choi IS, Kim SH

PURPOSE: Long-term treatment with inhaled steroids (ICS), especially fluticasone that developed lately, may suppress the hypothalamic-pituitary-adrenal (HPA) axis. This study investigated the relationship between ICS use and HPA axis suppression...
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Improvement of Eosinophilic Otitis Media by Optimized Asthma Treatment

Tanaka Y, Nonaka M, Yamamura Y, Tagaya E, Pawankar R, Yoshihara

Eosinophilic otitis media (EOM) shows a very high rate of association with asthma, and intractable otitis media involves marked eosinophil infiltration into the middle ear. The middle ear space is...
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The Efficacy of Immediate Diet for Reducing Local Adverse Events of Inhaled Corticosteroid: A Pilot Study

Lee MK, Lee WY, Yong SJ, Shin KC, Kim CW, Lee JH, Jung S, Jung YR, Kim HS, Yu TS, Kim SH

  • KMID: 2319898
  • Tuberc Respir Dis.
  • 2012 Aug;73(2):93-99.
BACKGROUND: Local adverse events associated with inhaled corticosteroid use, including dysphonia, pharyngitis and oral candidiasis, can affect adherence for treatment. 'Mouth rinsing method' has been used for reducing local adverse...
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The role of inhaled and/or nasal corticosteroids on the bronchodilator response

Lee JK, Suh DI, Koh YY

BACKGROUND: To compare the profiles of the bronchodilator response (BDR) among children with asthma and/or allergic rhinitis (AR) and to determine whether BDR in these children is reduced by treatment...
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Effects of Smoking Cessation on Airflow Obstruction and Quality of Life in Asthmatic Smokers

Jang AS, Park SW, Kim DJ, Uh S, Kim YH, Whang HG, Lim GI, Park CS

PURPOSE: Smoking elicits airway inflammation and airflow obstruction in patients with asthma, even after smoking cessation. The aim of this study was to examine the effects of smoking cessation on...
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Comparison for the Effects of Triple Therapy with Salmeterol/Fluticasone Propionate and Tiotropium Bromide versus Individual Components in Patients of Severe COPD Combined with Bronchial Hyperresponsiveness

Sohn JY, Kim SR, Park SJ, Lee HB, Lee YC, Rhee YK

  • KMID: 2319294
  • Tuberc Respir Dis.
  • 2009 Dec;67(6):536-544.
BACKGROUND: A combination of salmeterol and fluticasone propionate (SFC) and tiotropium bromide (TIO) is commonly prescribed for COPD patients but there is little data on their effectiveness, particularly in COPD...
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The Efficacy of Inhaled Corticosteroid on Chronic Idiopathic Cough

Han B, Jang SH, Kim YJ, Park S, Hwang YI, Kim DG, Kim CH, Hyun IG, Jung KS

  • KMID: 2319279
  • Tuberc Respir Dis.
  • 2009 Nov;67(5):422-429.
BACKGROUND: The discomfort caused by chronic cough, that is persistent for more than 3 weeks, causes a number of patients to seek medical attention. However, the underlying disorder often remains...
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An open, Multi center, Randomized, Parallel Group Study to Compare the Effectiveness and Safety of Fluticasone Plus Tulobuterol Versus Twice the Dose of Fluticasone Alone in Asthmatic Children

Jeon YH, Yang HJ, Yoo Y, Kim YH, Jeong JT, Lee HR, Pyun BY

  • KMID: 2314940
  • Pediatr Allergy Respir Dis.
  • 2009 Jun;19(2):125-136.
PURPOSE: We aim to compare the effectiveness and safety of fluticasone propionate (Flt) plus tulobuterol (Hk) versus high-dose Flt alone in controlling asthma in children. METHODS: Fifty three children aged 4...
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Economic Evaluations of Alternative Inhaled Steroid Medications in Patients with Asthma

  • KMID: 2234477
  • Korean J Asthma Allergy Clin Immunol.
  • 2008 Mar;28(1):26-34.
BACKGROUND: Asthma requires enormous social costs and deteriorates quality of life. Inhaled corticosteroids (ICSs) including budesonide (BUD), fluticasone propionate (FP), and ciclesonide (CIC) are currently considered the standard therapy for...
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The Effects of Corticosteroids on IL-6, IL-8 and RANTES Production from RSV-infected Epithelial Cells

  • KMID: 2299655
  • Korean J Asthma Allergy Clin Immunol.
  • 2005 Dec;25(4):305-312.
BACKGROUND: RSV induces the production of cytokines and chemokines in airway epithelial cells. Corticosteroids (CSs) can inhibit the production. OBJECTIVE: We examined whether the inhibitory effect of CSs on cytokines and...
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Effects of Corticosteroids on RANTES Production in Human Bronchial Epithelial Cell with Respiratory Syncytial Virus Infection

Lee EJ, Jeoun HJ, Yoon JS, Lee Y, Han JW, Lee JS

  • KMID: 2314389
  • Pediatr Allergy Respir Dis.
  • 2005 Sep;15(3):290-299.
PURPOSE: Respiratory syncytial virus (RSV) which is the most common cause of bronchiolitis in infants is an important triggering factor of asthma exacerbation in children. This virus stimulates chemokine such...
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The Efficacy and Safety of Inhaled Steroid Therapy for Prevention of Recurrent Wheezing after Bronchiolitis

Kim SR, Lim KH, Kim MJ, Kim YH, Jung JA, Yang S, Hwang IT, Lee HR

  • KMID: 2314352
  • Pediatr Allergy Respir Dis.
  • 2004 Dec;14(4):392-401.
PURPOSE: The purpose of this study was to evaluate the efficacy and metabolism of inhaled steroids to prevent recurrent wheezing after bronchiolitis. METHODS: Sixty two patients were randomly divided into...
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Effect of Intranasal Corticosteroid Therapy for Perennial Nonallergic Rhinitis and Perennial Allergic Rhinitis

Choi JM, sung MH, Lee SW, Bae YJ, Wang CW, Jung JA

  • KMID: 2314335
  • Pediatr Allergy Respir Dis.
  • 2004 Sep;14(3):199-206.
PURPOSE: The efficacy of intranasal corticosteroids for the treatment of allergic rhinitis has been reported. But the efficacy of intranasal corticosteroids has not been compared between perennial nonallergic rhinitis (PNAR)...
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