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Effect of Roxithromycin and Intranasal Fluticasone Spray in Reducing Symptoms of Chronic Sinusitis, Polyp Size and IL-4 in Allergic Patients

Kim BG, Lee DM, Jo JH, Jung DG, Kang JM, Kim SW

  • KMID: 2223307
  • J Rhinol.
  • 2003 Nov;10(1, 2):37-41.
Nasal polyp is an intractable condition usually associated with chronic hyperplastic sinusitis with allergic rhinitis. IL-4 is known to contribute to the inflammatory reaction by enhancing binding of inflammatory cells...
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Assessment of leukotriene E4 in exhaled breath condensate as a marker of inflammation and therapeutic effect in allergic rhinitis children

Kwak BO, Park YM

PURPOSE: Recent studies have shown that the cysteinyl leukotriene (cysLT) of exhaled breath condensate (EBC) could be predictive of inflammatory status and effectiveness of treatment in allergic disease. The aim...
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Effect of Inhaled Fluticasone Propionate on Hypothalamic-Pituitary-Adrenal Axis in Bronchial Asthma Patient

Hwang JK, Lee HM, No YW, Park GY, Park CW, Park JK, Jeong SH, Nam GH, Kim HK, Park HY, Kang MH

BACKGROUND: Inhaled glucocorticoids are the medical treatment of choice in asthma patients. Fluticasone propionate is one of the most effective inhaled corticosteroids and has been reported to have minimal effect...
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The Efficacy of Inhaled Corticosteroid on Chronic Idiopathic Cough

Han B, Jang SH, Kim YJ, Park S, Hwang YI, Kim DG, Kim CH, Hyun IG, Jung KS

  • KMID: 2319279
  • Tuberc Respir Dis.
  • 2009 Nov;67(5):422-429.
BACKGROUND: The discomfort caused by chronic cough, that is persistent for more than 3 weeks, causes a number of patients to seek medical attention. However, the underlying disorder often remains...
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Analysis of Induced Sputum to Examine the Effects of Inhaled Corticosteroid on the IL-8 and Myeloperoxidase in Asthmatic Subjects

Lee KH, Lee JY, Lee KM, Lee YH, Lee MA, Lee SJ, Park KS

  • KMID: 2314251
  • Pediatr Allergy Respir Dis.
  • 2001 Dec;11(4):300-309.
PURPOSE: The of this study was to describe the changes of airway inflammation in children with stable, steriod naive asthma after inhaling fluticasone by using serial induced sputum. We...
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Different anti-remodeling effect of nilotinib and fluticasone in a chronic asthma model

Kang HS, Rhee CK, Lee HY, Yoon HK, Kwon SS, Lee SY

BACKGROUND/AIMS: Inhaled corticosteroids are the most effective treatment currently available for asthma, but their beneficial effect against airway remodeling is limited. The tyrosine kinase inhibitor nilotinib has inhibitory activity against...
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Effect of Short Term Treatment with Different Dosage of Inhaled Flucatisone Propionate on Basal Cortisol Concentration

Kim HJ, Kim HS, Lee H, Lim ST, Moon SG, Park JH, Lee HB, Lee YC, Rhee YK

  • KMID: 2318086
  • Tuberc Respir Dis.
  • 1997 Oct;44(5):1063-1071.
BACKGROUND: The efficacy of oral corticosteroids in the treatment of chronic asthma is undisputed, but their long-term use is associated with adverse side-effects, including supression of the hypothalamic-pituitary adrenal axis...
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An open, Multi center, Randomized, Parallel Group Study to Compare the Effectiveness and Safety of Fluticasone Plus Tulobuterol Versus Twice the Dose of Fluticasone Alone in Asthmatic Children

Jeon YH, Yang HJ, Yoo Y, Kim YH, Jeong JT, Lee HR, Pyun BY

  • KMID: 2314940
  • Pediatr Allergy Respir Dis.
  • 2009 Jun;19(2):125-136.
PURPOSE: We aim to compare the effectiveness and safety of fluticasone propionate (Flt) plus tulobuterol (Hk) versus high-dose Flt alone in controlling asthma in children. METHODS: Fifty three children aged 4...
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Fluticasone Propionate and Beclomethasone Dipropionate in Asthmatic Patients

Yang DK, Kim YS, Ahn CM, Ko WK, Chang J, Kim SK, Lee WY

  • KMID: 2318245
  • Tuberc Respir Dis.
  • 1999 Nov;47(5):629-641.
BACKGROUND: Corticosteroid is most potent and effective anti-inflammatory medication currently available and inhaled form has been used in the long-term control of asthma. Fluticasone propionate(Flixotide/Flovent : FP) is highly potent...
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Pharmacokinetic characteristics of fluticasone, salmeterol and tiotropium after concurrent inhalation

Sunwoo J, Rhee SJ, Lee S, Lee SW, Jung J, Son H, Jang IJ

Chronic obstructive pulmonary disease (COPD) is a type of progressive, obstructive lung disease characterized by long-term poor airflow. The symptoms of COPD may be relieved and its progression delayed by...
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The Effects of Olfactory Training with Intranasal Corticosteroid Spray in Korean Patients with Olfactory Dysfunction

Jung YD, Kim DS, Kang BJ, Shin SH, Ye MK

BACKGROUND AND OBJECTIVES: Olfactory training is an alternative treatment based on modulation of the regeneration process of the olfactory system via repeated exposure to odors. Our study aimed to investigate...
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The role of inhaled and/or nasal corticosteroids on the bronchodilator response

Lee JK, Suh DI, Koh YY

BACKGROUND: To compare the profiles of the bronchodilator response (BDR) among children with asthma and/or allergic rhinitis (AR) and to determine whether BDR in these children is reduced by treatment...
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Effects of Smoking Cessation on Airflow Obstruction and Quality of Life in Asthmatic Smokers

Jang AS, Park SW, Kim DJ, Uh S, Kim YH, Whang HG, Lim GI, Park CS

PURPOSE: Smoking elicits airway inflammation and airflow obstruction in patients with asthma, even after smoking cessation. The aim of this study was to examine the effects of smoking cessation on...
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The Effect of Glucocorticosteroids on Eosinophil Apoptosis Primed by Cultured Nasal Polyp Epithelial Cell Supernatant

Shin SH, Ye MK, Choi JW, Kim SK, Jeong HS, Park JS

  • KMID: 2274765
  • Korean J Otolaryngol-Head Neck Surg.
  • 2000 Nov;43(11):1196-1201.
BACKGROUND AND OBJECTIVES: Eosinophil infiltration into inflammatory site is a characteristic histological finding in patients with allergic rhinitis, bronchial asthma, and nasal polyps. The regulation of eosinophil survival and apoptosis...
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Suppressive effects of long-term treatment with inhaled steroids on hypothalamic-pituitary-adrenal axis in asthma

Sim DW, Choi IS, Kim SH

PURPOSE: Long-term treatment with inhaled steroids (ICS), especially fluticasone that developed lately, may suppress the hypothalamic-pituitary-adrenal (HPA) axis. This study investigated the relationship between ICS use and HPA axis suppression...
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Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial

Woo SD, Ye YM, Lee Y, Lee SH, Shin YS, Park JH, Choi H, Lee HY, Shin HJ, Park HS

PURPOSE: Asthma control in older asthmatics is often less effective, which may be attributed to small airway dysfunction and poor inhalation technique. We compared the efficacy of 2 inhalers (fluticasone...
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Comparison for the Effects of Triple Therapy with Salmeterol/Fluticasone Propionate and Tiotropium Bromide versus Individual Components in Patients of Severe COPD Combined with Bronchial Hyperresponsiveness

Sohn JY, Kim SR, Park SJ, Lee HB, Lee YC, Rhee YK

  • KMID: 2319294
  • Tuberc Respir Dis.
  • 2009 Dec;67(6):536-544.
BACKGROUND: A combination of salmeterol and fluticasone propionate (SFC) and tiotropium bromide (TIO) is commonly prescribed for COPD patients but there is little data on their effectiveness, particularly in COPD...
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Efficacy and predictors of response to inhaled corticosteroid treatment for chronic cough

Hong JY, Kim JH, Park S, Hwang YI, Jung KS, Jang SH

BACKGROUND/AIMS: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial. METHODS: We conducted a prospective observational study...
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Expression of Vascular Cell Adhesion Molecule-1 on Vascular Endothelium in Nasal Polyps with Topical Steroid Treatment

Min YG, Jung YH, Kim JW, Rhee CS, Lee SS, Won TB, Oh SJ

  • KMID: 2275824
  • Korean J Otolaryngol-Head Neck Surg.
  • 2001 Nov;44(11):1164-1167.
BACKGROUND AND OBJECTIVES: Topical steroid therapy may play an important role in reducing the vascular cell adhesion molecule-1(VCAM-1) expression in the nasal polyp. Various adhesion molecules such as VCAM-1 promote...
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Improvement of Eosinophilic Otitis Media by Optimized Asthma Treatment

Tanaka Y, Nonaka M, Yamamura Y, Tagaya E, Pawankar R, Yoshihara

Eosinophilic otitis media (EOM) shows a very high rate of association with asthma, and intractable otitis media involves marked eosinophil infiltration into the middle ear. The middle ear space is...
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