Korean J Otolaryngol-Head Neck Surg.  2001 Nov;44(11):1164-1167.

Expression of Vascular Cell Adhesion Molecule-1 on Vascular Endothelium in Nasal Polyps with Topical Steroid Treatment

• Min YG
• Jung YH
• Kim JW
• Rhee CS
• Lee SS
• Won TB
• Oh SJ

Abstract

BACKGROUND AND OBJECTIVES: Topical steroid therapy may play an important role in reducing the vascular cell adhesion molecule-1(VCAM-1) expression in the nasal polyp. Various adhesion molecules such as VCAM-1 promote formation of nasal polyp and they show different sensitivity to steroid therapy. Changes in the VCAM-1 expression after a 8-week intranasal steroid treatment were investigated.
MATERIALS AND METHODS
The endothelial expression of VCAM-1 in biopsy specimens from the nasal polyps and inferior turbinates was investigated using the immunohistochemical staining in 20 patients with nasal polyposis. Biopsy specimens were obtained before, immediately after and 2 months after treatment with 100g fluticasone propionate in each nostril twice daily. The immunohistochemical activity in pretreatment and posttreatment specimens was analyzed.
RESULTS
The VCAM-1 expression was significantly higher in the nasal polyps than in inferior turbinates(p=0.002). Immediately after the treatment, the VCAM-1 expression in the nasal polyps was significantly reduced(p=0.001). But the VCAM-1 expression in nasal polyps returned to the pretreatment level 2 months after the treatment.
CONCLUSIONS
Intranasal steroid therapy may have an anti-inflammatory effect on nasal polyps by down regulating the VCAM-1 expression

Keyword

Vascular cell adhesion molecule-1; Nasal polyps; Steroids; Vascular endothelium

MeSH Terms

Biopsy
Cell Adhesion
Diethylpropion
Endothelium, Vascular*
Humans
Nasal Polyps*
Steroids
Turbinates
Vascular Cell Adhesion Molecule-1*
Fluticasone
Diethylpropion
Steroids
Vascular Cell Adhesion Molecule-1