- Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter
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Im SS, Kim JW, Kim TH, Song XL, Kim SY, Kim HI, Ahn YH
- KMID: 755748
- Exp Mol Med.
- 2005 Apr;37(2):101-110.
In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-gamma in the liver. Rosiglitazone, PPAR-gamma agonist, activated the GLUT2... -
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- Common interleukin 10 polymorphism associated with decreased risk of tuberculosis
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Shin HD, Park BL, Kim LH, Cheong HS, Lee IH, Park SK
- KMID: 755751
- Exp Mol Med.
- 2005 Apr;37(2):128-132.
Interleukin 10 (IL10) is a powerful TH2-cell cytokine that inhibits lymphocyte replication and secretion of inflammatory cytokines. The genetic associations of polymorphisms in IL10 with clinical manifestations of tuberculosis (TB)... -
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- Analysis of the factors affecting the accuracy of detection for single base alterations by oligonucleotide microarray
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Liu S, Li Y, Fu X, Qiu M, Jiang B, Wu H, Li R, Mao Y, Xie Y
- KMID: 755744
- Exp Mol Med.
- 2005 Apr;37(2):71-77.
The oligonucleotide microarray, a high-throughput polymorphism detection technology, holds great promise for the characterization of complex genetic variance. To achieve greater sensitivity and specificity for it to be an effective... -
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- Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro
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Hur JM, Shim JS, Jung HJ, Kwon HJ
- KMID: 755752
- Exp Mol Med.
- 2005 Apr;37(2):133-137.
In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of... -
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- HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1
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Shin JY, Hur W, Wang JS, Jang JW, Kim CW, Bae SH, Jang SK, Yang SH, Sung YC, Kwon OJ, Yoon SK
- KMID: 755753
- Exp Mol Med.
- 2005 Apr;37(2):138-145.
Liver cirrhosis is one of the major complications of hepatitis C virus (HCV) infection, but the mechanisms underlying HCV-related fibrogenesis are still not clear. Although the roles of HCV core... -
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- In vivo characterization of the integrin beta3 as a receptor for Hantaan virus cellular entry
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Song JW, Song KJ, Baek LJ, Frost B, Poncz M, Park KS
- KMID: 755750
- Exp Mol Med.
- 2005 Apr;37(2):121-127.
Binding of viruses to cell surface molecules is an essential step in viral infection. In vitro studies suggested that the alpha v beta3 integrin receptor is the epithelial cell receptor... -
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- Obesity and genetic polymorphism of ERCC2 and ERCC4 as modifiers of risk of breast cancer
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Lee SA, Lee KM, Park WY, Kim B, Nam J, Yoo KY, Noh DY, Ahn SH, Hirvonen A, Kang D
- KMID: 755746
- Exp Mol Med.
- 2005 Apr;37(2):86-90.
To evaluate the relationship of genetic polymorphisms of ERCC2 and ERCC4 genes, both involved in nucleotide excision repair (NER), and the risk of breast cancer, a hospital-based case-control study was... -
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- CD137 induces adhesion and cytokine production in human monocytic THP-1 cells
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Choi JW, Lee HW, Roh GS, Kim HH, Kwack KB
- KMID: 755745
- Exp Mol Med.
- 2005 Apr;37(2):78-85.
CD137, which is expressed on activated T cells, plays a critical role in inflammatory responses. However, the exact role that CD137 plays in monocytes is not fully known. Here we... -
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- Antitumor activity of spinasterol isolated from Pueraria roots
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Jeon GC, Park MS, Yoon DY, Shin CH, Sin HS, Um SJ
- KMID: 755749
- Exp Mol Med.
- 2005 Apr;37(2):111-120.
We purified phytoestrogens from Pueraria root (Pueraria mirifica from Thailand and Pueraria lobata from Korea), which is used as a rejuvenating folk medicine in Thailand and China. Dried, powdered plant... -
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- Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells
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Jung SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH
- KMID: 755747
- Exp Mol Med.
- 2005 Apr;37(2):91-100.
The calcium sensing receptor (CaSR) plays an important role for sensing local changes in the extracellular calcium concentration ([Ca2+]o) in bone remodeling. Although the function of CaSR is known, the... -
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