Exp Mol Med.  2005 Apr;37(2):128-132.

Common interleukin 10 polymorphism associated with decreased risk of tuberculosis

Affiliations
  • 1Department of Genetic Epidemiology, SNP Genetics, Inc., 11th Floor, MaeHun B/D, 13 Jongno 4-ga, Jongno-gu, Seoul, Korea. pulmo116@empal.com
  • 2Clinical Research Center for Tuberculosis, National Masan Tuberculosis Hospital, 486 Gapo-dong, Masan, Korea.

Abstract

Interleukin 10 (IL10) is a powerful TH2-cell cytokine that inhibits lymphocyte replication and secretion of inflammatory cytokines. The genetic associations of polymorphisms in IL10 with clinical manifestations of tuberculosis (TB) were examined in a large number of patients with clinical TB infection (n=459) and normal controls (n=871). One common promoter SNP (IL10 -592 A>C) was found to be significantly associated with decreased risk of TB manifestation. The frequency of the "C"-bearing genotype was higher in normal controls than in patients with clinical TB infection (P=0.005, OR=0.69). A summary of the genetic effect of IL10 -1082 A>G, the other nearby promoter SNP, in other ethnic groups is also presented.

Keyword

IL10; polymorphism; tuberculosis
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