Exp Mol Med.  2005 Apr;37(2):128-132.

Common interleukin 10 polymorphism associated with decreased risk of tuberculosis

• Shin HD
• Park BL
• Kim LH
• Cheong HS
• Lee IH
• Park SK

Abstract

Interleukin 10 (IL10) is a powerful TH2-cell cytokine that inhibits lymphocyte replication and secretion of inflammatory cytokines. The genetic associations of polymorphisms in IL10 with clinical manifestations of tuberculosis (TB) were examined in a large number of patients with clinical TB infection (n=459) and normal controls (n=871). One common promoter SNP (IL10 -592 A>C) was found to be significantly associated with decreased risk of TB manifestation. The frequency of the "C"-bearing genotype was higher in normal controls than in patients with clinical TB infection (P=0.005, OR=0.69). A summary of the genetic effect of IL10 -1082 A>G, the other nearby promoter SNP, in other ethnic groups is also presented.

Keyword

IL10; polymorphism; tuberculosis

MeSH Terms

Adolescent
Adult
Aged
Aged, 80 and over
*Genetic Predisposition to Disease
Genotype
Humans
Interleukin-10/*genetics
Korea
Middle Aged
Polymorphism, Single Nucleotide
Research Support, Non-U.S. Gov't
Risk
Tuberculosis, Pulmonary/*genetics