J Biomed Transl Res.  2016 Sep;17(3):52-57. 10.12729/jbtr.2016.17.3.052.

Interleukin-10 polymorphism (-1082, G/A) on acute rejection risk in solid organ transplant recipients in a Caucasian population: a meta-analysis

• Jang HM

• KMID: 2368697
• DOI: http://doi.org/10.12729/jbtr.2016.17.3.052

Abstract

Cytokines may play an important role in the acute rejection (AR) of solid organ transplantation. Many studies have investigated the association between interleukin-10 gene (IL-10) polymorphisms and risk of AR. The aim of this study was to determine the relationship between IL-10 polymorphism (-1082, G/A) and AR risk after solid organ transplantation in Caucasian population. A comprehensive electronic search of PUBMED, Google Scholar, and Korean databases was performed. Meta-analysis was performed using comprehensive meta-analysis software (Biostat, NJ,USA). We assessed the pooled p-value, odds ratio (OR), and 95% confidence interval (CI) to measure the association between the risk of AR and IL-10 polymorphism (-1082, G/A). The OR and 95% CI were used to evaluate the strength of the association. P-values less than 0.05 were considered statistically significant. Fourteen case-control studies were included in this meta-analysis. In overall analysis, we observed that IL-10 polymorphism (-1082, G/A) was associated with the AR in liver transplantation (G allele vs. A allele, OR = 1.436, 95% CI = 1.006-2.050, p = 0.046 in fixed model). However, IL-10 polymorphism (-1082, G/A) did not show any significant association with solid organ transplantation and renal transplantation (p>0.05 in each model, respectively). Our meta-analysis suggests that IL-10 polymorphism (-1082, G/A) may be related to susceptibility of AR in liver transplantation recipients.

Keyword

IL-10; polymorphism; acute rejection; meta-analysis; transplantation

MeSH Terms

Alleles
Case-Control Studies
Cytokines
Interleukin-10*
Kidney Transplantation
Liver Transplantation
Odds Ratio
Organ Transplantation
Transplantation
Transplants*
Cytokines
Interleukin-10