- Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
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Han S, Huh J, Kim W, Jeong S, Min DS, Jung Y
- KMID: 2155391
- Exp Mol Med.
- 2014 Dec;46(12):e126.
- doi: 10.1038/emm.2014.86
Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Therefore, PLD is... -
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- Inflammation and Cancer Development in Pancreatic and Biliary Tract Cancer
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Lee SH, Park SW
- KMID: 2373366
- Korean J Gastroenterol.
- 2015 Dec;66(6):325-339.
- doi: 10.4166/kjg.2015.66.6.325
Chronic inflammation has been known to be a risk for many kinds of cancers, including pancreatic and biliary tract cancer. Recently, inflammatory process has emerged as a key mediator of... -
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- Clinicopathlogic and Immunohistochemical Characteristics of Triple Negative Invasive Lobular Carcinoma
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Koo JS, Jung W
- KMID: 1106442
- Yonsei Med J.
- 2011 Jan;52(1):89-97.
- doi: 10.3349/ymj.2011.52.1.89
PURPOSE: Our study is performed to find out clinicopathlogic and immunohistochemical (IHC) characteristics of triple negative invasive lobular carcinoma (ILC), as has been demonstrated in their invasive ductal counterparts. MATERIALS... -
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- Increasing the alpha 2, 6 Sialylation of Glycoproteins May Contribute to Metastatic Spread and Therapeutic Resistance in Colorectal Cancer
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Park JJ, Lee M
- KMID: 1712321
- Gut Liver.
- 2013 Nov;7(6):629-641.
Abnormal glycosylation due to dysregulated glycosyltransferases and glycosidases is a key phenomenon of many malignancies, including colorectal cancer (CRC). In particular, increased ST6 Gal I (beta-galactoside alpha 2, 6 sialyltransferase)... -
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- EGF Induced RET Inhibitor Resistance in CCDC6-RET Lung Cancer Cells
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Chang H, Sung JH, Moon SU, Kim HS, Kim JW, Lee JS
- KMID: 2374183
- Yonsei Med J.
- 2017 Jan;58(1):9-18.
- doi: 10.3349/ymj.2017.58.1.9
PURPOSE: Rearrangement of the proto-oncogene rearranged during transfection (RET) has been newly identified potential driver mutation in lung adenocarcinoma. Clinically available tyrosine kinase inhibitors (TKIs) target RET kinase activity, which... -
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- Immunophenotypes of Glycogen Rich Clear Cell Carcinoma
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Kim SE, Koo JS, Jung WH
- KMID: 1414256
- Yonsei Med J.
- 2012 Nov;53(6):1142-1146.
- doi: 10.3349/ymj.2012.53.6.1142
PURPOSE: Glycogen rich clear cell carcinoma (GRCC) of the breast is a rare subtype of invasive ductal carcinoma and involves a poor prognosis. In the literature, less than 150 cases... -
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- VEGF as a Predictor for Response to Definitive Chemoradiotherapy and COX-2 as a Prognosticator for Survival in Esophageal Squamous Cell Carcinoma
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Yoon MS, Nam TK, Lee JS, Cho SH, Song JY, Ahn SJ, Chung IJ, Jeong JU, Chung WK, Nah BS
- KMID: 1777881
- J Korean Med Sci.
- 2011 Apr;26(4):513-520.
- doi: 10.3346/jkms.2011.26.4.513
We investigated the patterns of pretreatment expression of the epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and cyclooxygenase-2 (COX-2) by immunohistochemical staining and determined their correlation with... -
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- Combined treatment with silibinin and either sorafenib or gefitinib enhances their growth-inhibiting effects in hepatocellular carcinoma cells
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Gu HR, Park SC, Choi SJ, Lee JC, Kim YC, Han CJ, Kim J, Yang KY, Kim YJ, Noh GY, No SH, Jeong JH
- KMID: 2155291
- Clin Mol Hepatol.
- 2015 Mar;21(1):49-59.
- doi: 10.3350/cmh.2015.21.1.49
BACKGROUND/AIMS: Silibinin, the main component of silymarin, is used as a hepatoprotectant and exhibits anticancer effects against various cancer cells. This study evaluated the effects of a combination of silibinin... -
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- Clinicopathologic and Molecular Characteristics of Lung Adenocarcinoma Arising in Young Patients
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Kim L, Kim KH, Yoon YH, Ryu JS, Choi SJ, Park IS, Han JY, Kim JM, Chu YC
- KMID: 1782135
- J Korean Med Sci.
- 2012 Sep;27(9):1027-1036.
- doi: 10.3346/jkms.2012.27.9.1027
Lung cancer rarely occurs in young patients. Recent studies have demonstrated that epidemiologic data are closely correlated to some molecular characteristics. We investigated the clinicopathologic characteristics of lung adenocarcinoma in... -
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- Correlation between EGFR and c-erbB-2 oncoprotein status and response to neoadjuvant chemotherapy in cervical carcinoma
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Kim JW, Kim YT, Kim DK
- KMID: 711638
- Yonsei Med J.
- 1999 Jun;40(3):207-214.
- doi: 10.3349/ymj.1999.40.3.207
Neoadjuvant chemotherapy prior to definitive radical surgery or radiotherapy may be effective in reducing tumor volume or clinical stage and may even enhance pelvic control and survival. However,... -
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- Role of STAT3 as a Negative Regulator in Mac2- Binding Protein Expression
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Park YP, Kim JT, Yang Y, Lim JS, Yoon DY, Kim JW, Lee HG
- KMID: 854872
- Korean J Lab Med.
- 2008 Jun;28(3):230-238.
- doi: 10.3343/kjlm.2008.28.3.230
BACKGROUND: Mac-2 binding protein (Mac-2BP) is a secreted glycoprotein from the culture fluid of several human cancer cells, especially breast, lung, and gastric cells. Mac-2BP plays a role in immune... -
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