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A Case of Combination Therapy with Finasteride and Low Dose Dutasteride in the Treatment of Androgenetic Alopecia

Lee SY, Chun SW, Kim JB, Ro BI

  • KMID: 2371094
  • Korean J Dermatol.
  • 2017 Feb;55(2):147-148.
No abstract available.
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Positive Role of Dutasteride in the Treatment of Localized Prostate Cancer

Kim JH

Dual inhibition of both 5AR1 and 5AR2 by dutasteride provides greater and more consistent inhibition of the conversion of testosterone to dihydrotestosterone (DHT) than selective inhibition of 5AR2 alone. Beyond...
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The Different Reduction Rate of Prostate-Specific Antigen in Dutasteride and Finasteride

Choi YH, Cho SY, Cho IR

  • KMID: 2314614
  • Korean J Urol.
  • 2010 Oct;51(10):704-708.
PURPOSE: To compare and analyze the therapeutic effects and changes in the prostate-specific antigen (PSA) level with treatment with finasteride or dutasteride for benign prostatic hyperplasia (BPH) for 1 year. MATERIALS...
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The Effect of Dutasteride on Serum Prostate-specific Antigen (PSA) in Patients with Benign Prostate Hypertrophy

Lee GH, Hong JH, Kim HJ

  • KMID: 2330634
  • J Korean Continence Soc.
  • 2008 Jun;12(1):42-47.
PURPOSE: 5alpha reductase, dutasteride, has widely used to treat enlarged prostate (BPH). By suppressing the conversion of testosterone to dihydrotestosterone it decreases serum prostate-specific antigen (PSA) which is very important...
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Clinical Significance of Transrectal Ultrasonography and Efficacy of Dutasteride Treatment in Patients with Hemospermia

Kim YJ, Hwang EC, Kim SO, Jung SI, Kang TW, Kwon DD, Park K, Ryu SB

PURPOSE: The aims of this study were to investigate the clinical significance of transrectal ultrasonography (TRUS) and the efficacy of dutasteride (5alpha-reductase inhibitor) in patients with hemospermia. MATERIALS AND METHODS: From...
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The Effect of Two Weeks of Treatment with Dutasteride on Bleeding after Transurethral Resection of the Prostate

Kim KS, Jeong WS, Park SY, Kim YT, Moon HS

PURPOSE: Dutasteride affects the prostate by reducing intraprostatic dihydrotestosterone and prostate tissue vascularity. We evaluated the effect of pretreatment with dutasteride for two weeks on perioperative and postoperative bleeding during...
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Effects of Medication with Dutasteride on Detection of Prostate Cancer in Patients with Serum Prostate-specific Antigen Level of 4~10 ng/ml

Shin JS, Cho SR

  • KMID: 2298767
  • Korean J Androl.
  • 2008 Apr;26(1):29-34.
Purpose: We assessed the effects of medication with dutasteride on serum prostate-specific antigen (PSA), PSA density (PSAD) and prostate volume to avoid unnecessary biopsies. Materials and Methods: Between 2005 and 2007...
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Significance of intraprostatic architecture and regrowth velocity for considering discontinuation of dutasteride after combination therapy with an alpha blocker: A prospective, pilot study

Shindo T, Hashimoto , Shimizu T, Itoh N, Masumori N

PURPOSE: We conducted a prospective single-center study to evaluate the possibility of discontinuation of dutasteride after combination therapy with an alpha blocker for benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: We...
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The Effect of Short Term Dutasteride Therapy on Microvessel Density in Benign Prostatic Hyperplasia

Woo JH, Kang JY, Kim EK, Yoo TK

  • KMID: 2311982
  • Korean J Urol.
  • 2008 Jun;49(6):515-519.
PURPOSE: Several studies have shown that finasteride limits hematuria in patients with benign prostatic hyperplasia(BPH). However, there are few reports addressing dutasteride therapy. We evaluated the effect of dutasteride on...
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Changes in Sexual Function in Benign Prostatic Hyperplasia Patients Taking Dutasteride: 1-Year Follow-Up Results

Chi BH, Kim SC

  • KMID: 2315428
  • Korean J Urol.
  • 2011 Sep;52(9):632-636.
PURPOSE: Sexual adverse events (AEs), a major cause for discontinuing 5alpha-reductase inhibitor (5ARI) therapy for benign prostatic hyperplasia (BPH), are known to occur most frequently early in therapy and appear...
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Post-marketing Surveillance of the Safety of Dutasteride Prescribed to Korean Patients with Benign Prostate Hyperplasia

Kim JH, Bae JY, Oh SY, Lee YS

  • KMID: 2334523
  • J Korean Soc Clin Pharmacol Ther.
  • 2012 Jun;20(1):85-94.
BACKGROUND: Dutasteride is an inhibitor of both types I and II 5 alpha-reductase and was approved in Korea in April 2004. This post-marketing surveillance was to assess the safety of...
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Retrospective Pharmacotherapeutic Evaluation of Dutasteride not Approved by US FDA for Androgenetic Alopecia in Korea

Cheon YJ, Kim JT, Lim SC

BACKGROUND: Androgenetic alopecia (AGA), one of alopecias, requires continuous treatment in order to prevent or stop it, and patient's compliance is very important. Currently, only two drugs (finasteride, minoxidil) have...
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Early dutasteride monotherapy in men with detectable serum prostate-specific antigen levels following radical prostatectomy: A prospective trial

Shin YS, Lee JW, Kim MK, Jeong YB, Park SC

PURPOSE: To investigate the effects of early administration of dutasteride in patients with detectable serum prostate-specific antigen (PSA) levels after radical prostatectomy (RP). MATERIALS AND METHODS: A prospective open-label study, with...
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Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment

Sung HH, Yu J, Kang SJ, Chae MR, So I, Park JK, Lee SW

PURPOSE: The current study is aimed to assess whether a longer duration of 5α-reductase inhibitor (5α-RI) exposure was associated with higher rate of permanent erectile dysfunction (ED) in a rat...
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Comparison of Clinical Efficacy of Finasteride and Dutasteride as 5-alpha Reductase Inhibitor

Choi H, Chang YS, Park BH, Ko DH, Moon YJ, Kim JB

PURPOSE: To compare the clinical therapeutic efficacy of finasteride and dutasteride as 5-alpha reductase inhibitor (5-ARI) in the medical treatment of benign prostate hyperplasia. MATERIALS AND METHODS: From July 2007 to...
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Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia

Choi GS, Kim JH, Oh SY, Park JM, Hong JS, Lee YS, Lee WS

BACKGROUND: After the approval of dutastride for androgenic alopecia (AGA) in 2009, Korean authority required a post-marketing surveillance to obtain further data on its safety profile. OBJECTIVE: The objective was to...
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Association of Polymorphisms in the Prostate-Specific Antigen (PSA) Gene Promoter with Serum PSA Level and PSA Changes after Dutasteride Treatment in Korean Men with Benign Prostatic Hypertrophy

Park SW, Kim CS, Lee G

  • KMID: 2314582
  • Korean J Urol.
  • 2010 Dec;51(12):824-830.
PURPOSE: Studies of genetic variation in the prostate-specific antigen (PSA) gene have improved the diagnostic accuracy of PSA for diagnosing prostate diseases in Caucasians. However, the reference ranges and pharmacokinetics...
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Current Status of 5alpha-Reductase Inhibitors in Prostate Disease Management

Kang DI, Chung JI

  • KMID: 2316025
  • Korean J Urol.
  • 2013 Apr;54(4):213-219.
The key enzyme in the androgen synthesis and androgen receptor pathways is 5alpha-reductase (5-AR), which occurs as three isoenzymes. Types I and II 5-ARs the most important clinically, and two...
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Impact of Treatment With Statins on Prostate-Specific Antigen and Prostate Volume in Patients With Benign Prostatic Hyperplasia

Lee SH, Park TJ, Bae MH, Choi SH, Cho YS, Joo KJ, Kwon CH, Park HJ

  • KMID: 2315955
  • Korean J Urol.
  • 2013 Nov;54(11):750-755.
PURPOSE: We investigated the impact on prostate-specific antigen (PSA) and prostate volume (PV) of statin medication for 1 year in patients with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: We retrospectively...
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Hair characteristics and androgenetic alopecia in Koreans

Choi GS

The scalp hair is composed of one hundred thousand of hairs. Each hair goes through the three phases of the hair cycle, which causes the hair to turn from an...
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