- The Generation and Application of Patient-Derived Xenograft Model for Cancer Research
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Jung J, Seol HS, Chang S
- KMID: 2403469
- Cancer Res Treat.
- 2018 Jan;50(1):1-10.
- doi: 10.4143/crt.2017.307
Establishing an appropriate preclinical model is crucial for translational cancer research. The most common way that has been adopted by far is grafting cancer cell lines, derived from patients. Although... -
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- Preclinical Experience in Stem Cell Therapy for Digestive Tract Diseases
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Jeon MS, Hong SS
- KMID: 1018400
- Korean J Gastroenterol.
- 2011 Sep;58(3):133-138.
- doi: 10.4166/kjg.2011.58.3.133
Adult stem cells are multipotent and self-renewing cells that contain several functions; i) migration and homing potential: stem cells can migrate to injured and inflamed tissues. ii) differentiation potential: stem... -
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- Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart
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Okada JI, Washio T, Sugiura S, Hisada T
- KMID: 2455805
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):295-303.
- doi: 10.4196/kjpp.2019.23.5.295
A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and... -
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- Stem Cells in Drug Screening for Neurodegenerative Disease
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Kim HJ, Jin CY
- KMID: 2285433
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):1-9.
- doi: 10.4196/kjpp.2012.16.1.1
Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us... -
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- Sequence-Dependent Radiosensitization of Histone Deacetylase Inhibitors Trichostatin A and SK-7041
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Kim JH, Kim IH, Shin JH, Kim HJ, Kim IA
- KMID: 2167644
- Cancer Res Treat.
- 2013 Dec;45(4):334-342.
PURPOSE: This preclinical study is to determine whether the capacity of histone deacetylase (HDAC) inhibitors to enhance radiation response depends on temporal sequences of HDAC inhibition and irradiation. MATERIALS AND METHODS:... -
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- Enhanced Chemotherapeutic Drug Delivery to Tumor Tissue by High Intensity Focused Ultrasound
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Jung JT, Lee DH, Hwang JH
- KMID: 783156
- Korean J Gastroenterol.
- 2009 Apr;53(4):216-220.
Cancer is the first leading cause of death in Korea. Systemic chemotherapy is currently the standard treatment for a wide variety of cancers; however, in the majority of cases, cure... -
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- Modeling of Human Genetic Diseases Via Cellular Reprogramming
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Kang MY, Suh JH, Han YM
- KMID: 1428896
- J Genet Med.
- 2012 Dec;9(2):67-72.
- doi: 10.5734/JGM.2012.9.2.67
The generation of induced pluripotent stem cells (iPSCs) derived from patients' somatic cells provides a new paradigm for studying human genetic diseases. Human iPSCs which have similar properties of human... -
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- Correlative Effect between in vivo Hollow Fiber Assay and Xenografts Assay in Drug Screening
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Lee KH, Rhee KH
- KMID: 2270839
- Cancer Res Treat.
- 2005 Jun;37(3):196-200.
PURPOSE: This study was carried out to assess the usage of an in vivo hollow fiber assay to screen drugs with highly predictive accuracy. MATERIALS AND METHODS: The assay systems... -
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- Availability of Toxicologic Screening Tests in the Emergency Department
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Um IK, Park JS, Han KS, Cho H, Choi SH, Lee SW, Hong YS
- KMID: 2203634
- J Korean Soc Clin Toxicol.
- 2011 Jun;9(1):26-29.
PURPOSE: The role of a point of care test (POCT) is currently becoming important when treating patients and making decisions in the emergency department. It also plays a role for... -
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- Higher Binding Affinity and In Vitro Potency of Reslizumab for Interleukin-5 Compared With Mepolizumab
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Liddament , Husten J, Estephan T, Laine D, Mabon D, Pukac L, Lyons J, Clarke AW, Doyle A
- KMID: 2431860
- Allergy Asthma Immunol Res.
- 2019 Mar;11(2):291-298.
- doi: 10.4168/aair.2019.11.2.291
Reslizumab and mepolizumab are recently approved monoclonal antibodies for the treatment of severe (uncontrolled) eosinophilic asthma. Both are effective in neutralizing the function of interleukin-5 (IL-5). This study is the... -
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- Induced Pluripotent Stem Cells as a Novel Tool in Psychiatric Research
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Kim S, Kim MK, Oh D, Lee SH, Kim B
- KMID: 2316592
- Psychiatry Investig.
- 2016 Jan;13(1):8-17.
- doi: 10.4306/pi.2016.13.1.8
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a valuable opportunity to study neurodevelopmental and neurodegenerative psychiatric diseases by offering an unlimited source for patient-specific neuronal and... -
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- Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy
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Kim CY, Park SH, Jeong M, Kwon OS, Doh H, Kang SH, Robbins PD, Kim BM, Seol DW, Kim BG
- KMID: 1123370
- Exp Mol Med.
- 2011 Oct;43(10):580-586.
- doi: 10.3858/emm.2011.43.10.065
Malignant glioma is the most frequent type in brain tumors. The prognosis of this tumor has not been significantly improved for the past decades and the average survival of patients... -
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- Mesenchymal stem cells in acute myeloid leukemia: a focus on mechanisms involved and therapeutic concepts
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Fathi E, Sanaat Z, Farahzadi
- KMID: 2459381
- Blood Res.
- 2019 Sep;54(3):165-174.
- doi: 10.5045/br.2019.54.3.165
Drug resistance in cancer, especially in leukemia, creates a dilemma in treatment planning. Consequently, studies related to the mechanisms underlying drug resistance, the molecular pathways involved in this phenomenon, and... -
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- The Control of Drug Release and Vascular Endothelialization after Hyaluronic Acid-Coated Paclitaxel Multi-Layer Coating Stent Implantation in Porcine Coronary Restenosis Model
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Bae IH, Jeong MH, Kim JH, Park YH, Lim KS, Park DS, Shim JW, Kim JH, Ahn Y, Hong YJ, Sim DS
- KMID: 2365291
- Korean Circ J.
- 2017 Jan;47(1):123-131.
- doi: 10.4070/kcj.2016.0203
BACKGROUND AND OBJECTIVES: Hyaluronic acid (HA) is highly biocompatible with cells and the extracellular matrix. In contrast to degradation products of a synthetic polymer, degradation products of HA do not... -
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- Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells
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An D, Kim K, Kim J
- KMID: 2170631
- Biomol Ther.
- 2014 Jul;22(4):355-362.
We have developed a fully automated high throughput drug screening (HTDS) system based on the microfluidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell... -
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- Recent Advances for Enhancing Drug Metabolizing Functions of Hepatocyte-like Cells Derived from Human Pluripotent Stem Cells
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Han J, Kim JH
- KMID: 2129472
- Hanyang Med Rev.
- 2015 Nov;35(4):196-206.
- doi: 10.7599/hmr.2015.35.4.196
Hepatocyte-like cells (HLCs) derived from human pluripotent stem cells are a promising cell source for drug screening and toxicity tests. Thus, various hepatic differentiating protocols have been developed, leading to... -
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- Ischemic Stroke after Use of Cannabis: a Case Report and Review of Literature
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Jung JS, Park YW, Lee SA, Song TJ, Lim SM
- KMID: 2421548
- Investig Magn Reson Imaging.
- 2018 Sep;22(3):168-171.
- doi: 10.13104/imri.2018.22.3.168
Cannabis or marijuana is the most commonly used recreational drug after alcohol in the world, and usage is generally recognized as having few serious adverse effects. However, usage is restricted... -
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- In Vitro Infectivity Assessment by Drug Susceptibility Comparison of Recombinant Leishmania major Expressing Enhanced Green Fluorescent Protein or EGFP-Luciferase Fused Genes with Wild-Type Parasite
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Sadeghi S, Seyed N, Etemadzadeh MH, Abediankenari S, Rafati S, Taheri T
- KMID: 2381755
- Korean J Parasitol.
- 2015 Aug;53(4):385-394.
- doi: 10.3347/kjp.2015.53.4.385
Leishmaniasis is a worldwide uncontrolled parasitic disease due to the lack of effective drug and vaccine. To speed up effective drug development, we need powerful methods to rapidly assess drug... -
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- Acebutolol, a Cardioselective Beta Blocker, Promotes Glucose Uptake in Diabetic Model Cells by Inhibiting JNK-JIP1 Interaction
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Li Y, Jung NY, Yoo JC, Kim Y, Yi GS
- KMID: 2421723
- Biomol Ther.
- 2018 Sep;26(5):458-463.
- doi: 10.4062/biomolther.2017.123
The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development... -
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- Applications of kidney organoids derived from human pluripotent stem cells
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Kim YK, Nam SA, Yang CW
- KMID: 2415990
- Korean J Intern Med.
- 2018 Jul;33(4):649-659.
- doi: 10.3904/kjim.2018.198
The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing... -
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