Korean J Gastroenterol.
2009 Apr;53(4):216-220.
Enhanced Chemotherapeutic Drug Delivery to Tumor Tissue by High Intensity Focused Ultrasound
- Affiliations
-
- 1Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. jungjt@cu.ac.kr
- 2Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea.
- 3University of Washington College of Medicine, Seattle, United State
Abstract
- Cancer is the first leading cause of death in Korea. Systemic chemotherapy is currently the standard treatment for a wide variety of cancers; however, in the majority of cases, cure is not achieved, and the attendant side effects of the treatment are considerable. The effectiveness of chemotherapy in cancers depends on the adequate delivery of the chemotherapeutic agent to cancer cells. The achievement of uniform drug delivery of chemotherapeutic agents throughout tumors is limited by the anomalous vascularization and blood vessel permeability. Ultrasound has an ever-increasing role in the delivery of therapeutic agents including chemotherapeutic agents, proteins, and genetic materials. Ultrasound technology allows for the use of focused ultrasound energy for therapeutic purposes by delivering high-intensity focused ultrasound for applications such as tissue ablation, and enhanced drug delivery. We reviewed recent work in the emerging field of ultrasound-based therapeutics, with particular emphasis on the delivery of drugs to tumor tissue.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- High-Intensity Focused Ultrasound Therapy: an Overview for Radiologists
- Current status of high-intensity focused ultrasound for the management of uterine adenomyosis
- Magnetic Resonance-Guided Focused Ultrasound : Current Status and Future Perspectives in Thermal Ablation and Blood-Brain Barrier Opening
- High Intensity Focused Ultrasound Treatment-Induced Tumor Lysis Syndrome in Uterine Myoma Patient
- Ultrasound-guided drug delivery in cancer
