Ultrasonography.  2017 Jul;36(3):171-184. 10.14366/usg.17021.

Ultrasound-guided drug delivery in cancer

• Mullick Chowdhury S
• Lee T
• Willmann J

• KMID: 2384793
• DOI: http://doi.org/10.14366/usg.17021

Abstract

Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.

Keyword

Ultrasonography; Drug delivery systems; Cancer therapy; Genetic therapy; Microbubbles

MeSH Terms

Drug Delivery Systems
Genetic Therapy
Microbubbles
Ultrasonography

Reference

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