- Follistatin Mitigates Myofibroblast Differentiation and Collagen Synthesis of Fibroblasts from Scar Tissue around Injured Flexor Tendons
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Kang YM, Lee SK, Chun YM, Choi YR, Moon SH, Lee HM, Kang HJ
- KMID: 2466340
- Yonsei Med J.
- 2020 Jan;61(1):85-93.
- doi: 10.3349/ymj.2020.61.1.85
PURPOSE: The aim of this study was to investigate the effect of FST gene on the inhibition of fibrosis in fibroblastic cells from scar tissue around repaired zone II flexor... -
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- Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model
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Yun IS, Kang E, Ahn HM, Kim YO, Rah DK, Roh TS, Lee WJ, Yun CO
- KMID: 2457481
- Yonsei Med J.
- 2019 Sep;60(9):854-863.
- doi: 10.3349/ymj.2019.60.9.854
PURPOSE: Relaxin (RLX) is a transforming growth factor-β1 (TGF-β1) antagonist that is believed to function as a potent collagen re-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads)... -
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- Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine
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Venkatesan JK, Rey-Rico A, Cucchiarini M
- KMID: 2455044
- Tissue Eng Regen Med.
- 2019 Aug;16(4):345-355.
- doi: 10.1007/s13770-019-00179-x
BACKGROUND: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains hindered by... -
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- Genetic Mutation Profiles in Korean Patients with Inherited Retinal Diseases
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Kim MS, Joo K, Seong MW, Kim MJ, Park KH, Park SS, Woo SJ
- KMID: 2456270
- J Korean Med Sci.
- 2019 Jun;34(21):e161.
- doi: 10.3346/jkms.2019.34.e161
BACKGROUND: Because of genetically and phenotypically heterogenous features, identification of causative genes for inherited retinal diseases (IRD) is essential for diagnosis and treatment in coming gene therapy era. To date,... -
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- Effects of TGF-β1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells
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Salkın H, Gönen ZB, Ergen E, Bahar D, Çetin M
- KMID: 2447235
- Int J Stem Cells.
- 2019 Mar;12(1):170-182.
- doi: 10.15283/ijsc18051
OBJECTIVE: The aim of our study was to investigate the effect of Transforming growth factor beta-1 (TGF-β1) gene therapy on the surface markers, multilineage differentiation, viability, apoptosis, cell cycle, DNA... -
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- Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury
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Shin JE, Han J, Lim JH, Eun HS, Park KI
- KMID: 2440695
- Neonatal Med.
- 2019 Feb;26(1):1-16.
- doi: 10.5385/nm.2019.26.1.1
Neonatal hypoxic-ischemic (HI) brain injury is a major cause of neonatal mortality and long-term neurodevelopmental disabilities. Although promising neuroprotective interventions have been studied, the current management of HI brain injury... -
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- Genetic Hearing Loss and Gene Therapy
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Carpena NT, Lee MY
- KMID: 2439210
- Genomics Inform.
- 2018 Dec;16(4):e20.
- doi: 10.5808/GI.2018.16.4.e20
Genetic hearing loss crosses almost all the categories of hearing loss which includes the following: conductive, sensory, and neural; syndromic and nonsyndromic; congenital, progressive, and adult onset; high-frequency, low-frequency, or... -
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- Sodium Iodide Symporter (NIS) in the Management of Patients with Thyroid Carcinoma
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Chung JK, Kim HW, Youn H, Cheon GJ
- KMID: 2422792
- Nucl Med Mol Imaging.
- 2018 Oct;52(5):325-326.
- doi: 10.1007/s13139-018-0540-y
Although radioiodine has been applied in thyroid diseases including carcinoma for over 70 years, it was only in 1996 that the basic molecular mechanism of iodine uptake was identified. Iodide... -
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- Progress of Hemophilia A Therapeutics in Korea
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Kim DH, Kim SK
- KMID: 2435419
- Clin Pediatr Hematol Oncol.
- 2018 Apr;25(1):17-22.
- doi: 10.15264/cpho.2018.25.1.17
Over the past several decades, hemophilia treatment in Korea has progressed dramatically. It has become possible to prevent hemophilia complications by maintenance treatment as well as on-demand treatment with the... -
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- A Survey of the Neuro-Oncology Landscape
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Lukas RV, Wu J, Dey M, Buerki RA, Byrne RW, Dohrmann G
- KMID: 2399593
- J Clin Neurol.
- 2018 Jan;14(1):8-15.
- doi: 10.3988/jcn.2018.14.1.8
The field of neuro-oncology is evolving rapidly. Many important advances have recently been reported, and other promising investigations have the potential to soon make substantial impacts in the field, especially... -
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- The Future Medical Science and Colorectal Surgeons
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Kim YJ
- KMID: 2439836
- Ann Coloproctol.
- 2017 Dec;33(6):207-209.
- doi: 10.3393/ac.2017.33.6.207
Future medical technology breakthroughs will build from the incredible progress made in computers, biotechnology, and nanotechnology and from the information learned from the human genome. With such technology and information,... -
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- Effects of Next-Generation Low-Energy Extracorporeal Shockwave Therapy on Erectile Dysfunction in an Animal Model of Diabetes
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Jeong HC, Jeon SH, Qun ZG, Kim KS, Choi SW, Bashraheel F, Bae WJ, Kim SJ, Cho HJ, Ha US, Hong SH, Lee JY, Moon DG, Kim SW
- KMID: 2398568
- World J Mens Health.
- 2017 Dec;35(3):186-195.
- doi: 10.5534/wjmh.17024
PURPOSE: Gene therapy, stem cell therapy, and low-energy extracorporeal shockwave therapy (ESWT) have been investigated as treatments for refractory erectile dysfunction (ED), but inconclusive evidence has been obtained. We investigated... -
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- AAV-Mediated Astrocyte-Specific Gene Expression under Human ALDH1L1 Promoter in Mouse Thalamus
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Koh W, Park YM, Lee SE, Lee CJ
- KMID: 2398423
- Exp Neurobiol.
- 2017 Dec;26(6):350-361.
- doi: 10.5607/en.2017.26.6.350
Adeno-associated virus (AAV)-mediated gene delivery has been proposed to be an essential tool of gene therapy for various brain diseases. Among several cell types in the brain, astrocyte has become... -
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- Glaucoma, Stem Cells, and Gene Therapy: Where Are We Now?
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Daliri K, Ljubimov A, Hekmatimoghaddam S
- KMID: 2400866
- Int J Stem Cells.
- 2017 Nov;10(2):119-128.
- doi: 10.15283/ijsc17029
Glaucoma is the second most common cause of blindness, affecting 70~80 million people around the world. The death of retinal ganglion cells (RGCs) is the main cause of blindness related... -
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- Current Treatment Options for Bilateral Vocal Fold Paralysis: A State-of-the-Art Review
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Li Y, Garrett G, Zealear D
- KMID: 2395733
- Clin Exp Otorhinolaryngol.
- 2017 Sep;10(3):203-212.
- doi: 10.21053/ceo.2017.00199
Vocal fold paralysis (VFP) refers to neurological causes of reduced or absent movement of one or both vocal folds. Bilateral VFP (BVFP) is characterized by inspiratory dyspnea due to narrowing... -
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- Keyword network analysis in stem cell research area
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Jang HL
- KMID: 2394591
- J Biomed Transl Res.
- 2017 Sep;18(3):75-83.
- doi: 10.12729/jbtr.2017.18.3.075
This study conducted a social network analysis to investigate stem cell research which was actively being studied as an alternative for the treatment of intractable diseases due to infinite proliferation... -
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- Follistatin N terminus differentially regulates muscle size and fat in vivo
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Zheng H, Qiao C, Tang R, Li J, Bulaklak K, Huang Z, Zhao C, Dai Y, Li J, Xiao X
- KMID: 2394308
- Exp Mol Med.
- 2017 Sep;49(9):e377.
- doi: 10.1038/emm.2017.135
Delivery of follistatin (FST) represents a promising strategy for both muscular dystrophies and diabetes, as FST is a robust antagonist of myostatin and activin, which are critical regulators of skeletal... -
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- Identification of Pathogenic Variants in the CHM Gene in Two Korean Patients With Choroideremia
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Bae K, Song JS, Lee C, Kim NK, Park WY, Kim BJ, Ki CS, Kim SJ
- KMID: 2383921
- Ann Lab Med.
- 2017 Sep;37(5):438-442.
- doi: 10.3343/alm.2017.37.5.438
Choroideremia is a rare X-linked disorder causing progressive chorioretinal atrophy. Affected patients develop night blindness with progressive peripheral vision loss and eventual blindness. Herein, we report two Korean families with... -
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- Ultrasound-guided drug delivery in cancer
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Mullick Chowdhury S, Lee T, Willmann J
- KMID: 2384793
- Ultrasonography.
- 2017 Jul;36(3):171-184.
- doi: 10.14366/usg.17021
Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing... -
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- Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor
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Hwang Y, Kim D, Chang D, Ahn B, Kim YB, Kim G
- KMID: 2412580
- J Vet Sci.
- 2017 Jun;18(2):257-260.
- doi: 10.4142/jvs.2017.18.2.257
This is the first case report to describe the tumor regressive effect of systemic human neural stem cell (NSC)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared... -
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