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Follistatin Mitigates Myofibroblast Differentiation and Collagen Synthesis of Fibroblasts from Scar Tissue around Injured Flexor Tendons

Kang YM, Lee SK, Chun YM, Choi YR, Moon SH, Lee HM, Kang HJ

PURPOSE: The aim of this study was to investigate the effect of FST gene on the inhibition of fibrosis in fibroblastic cells from scar tissue around repaired zone II flexor...
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Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model

Yun IS, Kang E, Ahn HM, Kim YO, Rah DK, Roh TS, Lee WJ, Yun CO

PURPOSE: Relaxin (RLX) is a transforming growth factor-β1 (TGF-β1) antagonist that is believed to function as a potent collagen re-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads)...
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Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine

Venkatesan JK, Rey-Rico A, Cucchiarini M

BACKGROUND: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains hindered by...
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Genetic Mutation Profiles in Korean Patients with Inherited Retinal Diseases

Kim MS, Joo K, Seong MW, Kim MJ, Park KH, Park SS, Woo SJ

BACKGROUND: Because of genetically and phenotypically heterogenous features, identification of causative genes for inherited retinal diseases (IRD) is essential for diagnosis and treatment in coming gene therapy era. To date,...
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Effects of TGF-β1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells

Salkın H, Gönen ZB, Ergen E, Bahar D, Çetin M

OBJECTIVE: The aim of our study was to investigate the effect of Transforming growth factor beta-1 (TGF-β1) gene therapy on the surface markers, multilineage differentiation, viability, apoptosis, cell cycle, DNA...
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Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury

Shin JE, Han J, Lim JH, Eun HS, Park KI

Neonatal hypoxic-ischemic (HI) brain injury is a major cause of neonatal mortality and long-term neurodevelopmental disabilities. Although promising neuroprotective interventions have been studied, the current management of HI brain injury...
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Progress of Hemophilia A Therapeutics in Korea

Kim DH, Kim SK

Over the past several decades, hemophilia treatment in Korea has progressed dramatically. It has become possible to prevent hemophilia complications by maintenance treatment as well as on-demand treatment with the...
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Genetic Hearing Loss and Gene Therapy

Carpena NT, Lee MY

Genetic hearing loss crosses almost all the categories of hearing loss which includes the following: conductive, sensory, and neural; syndromic and nonsyndromic; congenital, progressive, and adult onset; high-frequency, low-frequency, or...
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Sodium Iodide Symporter (NIS) in the Management of Patients with Thyroid Carcinoma

Chung JK, Kim HW, Youn H, Cheon GJ

Although radioiodine has been applied in thyroid diseases including carcinoma for over 70 years, it was only in 1996 that the basic molecular mechanism of iodine uptake was identified. Iodide...
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A Survey of the Neuro-Oncology Landscape

Lukas RV, Wu J, Dey M, Buerki RA, Byrne RW, Dohrmann G

The field of neuro-oncology is evolving rapidly. Many important advances have recently been reported, and other promising investigations have the potential to soon make substantial impacts in the field, especially...
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Current Treatment Options for Bilateral Vocal Fold Paralysis: A State-of-the-Art Review

Li Y, Garrett G, Zealear D

Vocal fold paralysis (VFP) refers to neurological causes of reduced or absent movement of one or both vocal folds. Bilateral VFP (BVFP) is characterized by inspiratory dyspnea due to narrowing...
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Keyword network analysis in stem cell research area

Jang HL

This study conducted a social network analysis to investigate stem cell research which was actively being studied as an alternative for the treatment of intractable diseases due to infinite proliferation...
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Follistatin N terminus differentially regulates muscle size and fat in vivo

Zheng H, Qiao C, Tang R, Li J, Bulaklak K, Huang Z, Zhao C, Dai Y, Li J, Xiao X

Delivery of follistatin (FST) represents a promising strategy for both muscular dystrophies and diabetes, as FST is a robust antagonist of myostatin and activin, which are critical regulators of skeletal...
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Identification of Pathogenic Variants in the CHM Gene in Two Korean Patients With Choroideremia

Bae K, Song JS, Lee C, Kim NK, Park WY, Kim BJ, Ki CS, Kim SJ

Choroideremia is a rare X-linked disorder causing progressive chorioretinal atrophy. Affected patients develop night blindness with progressive peripheral vision loss and eventual blindness. Herein, we report two Korean families with...
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Ultrasound-guided drug delivery in cancer

Mullick Chowdhury S, Lee T, Willmann J

Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing...
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Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor

Hwang Y, Kim D, Chang D, Ahn B, Kim YB, Kim G

This is the first case report to describe the tumor regressive effect of systemic human neural stem cell (NSC)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared...
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Gene Therapy for Hearing Protection

Lee MY

Sensorineural hearing loss (SNHL) does not recover and only few exceptions exist. It is mostly due to the reason that hair cells in the cochlea cannot regenerate once damaged. Therefore,...
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Detection of Autoantibodies against Aquaporin-1 in the Sera of Patients with Primary Sjögren's Syndrome

Alam J, Choi YS, Koh JH, Kwok SK, Park SH, Song YW, Park K, Choi Y

The pathophysiology of glandular dysfunction in Sjögren's syndrome (SS) has not been fully elucidated. Previously, we reported the presence of autoantibodies to AQP-5 in patients with SS, which was associated...
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Stem Cell Therapy for Neonatal Disorders: Prospects and Challenges

Chang YS, Ahn SY, Sung S, Park WS

Despite recent advances in neonatal medicine, neonatal disorders, such as bronchopulmonary dysplasia and intraventricular hemorrhage in preterm neonates and hypoxic ischemic encephalopathy in term neonates, remain major causes of mortality...
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Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study

Jung BK, Lee WJ, Kang E, Ahn HM, Kim YO, Rah DK, Yun CO, Yun IS

BACKGROUND: Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a...
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