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Colocalization of Interferon Regulatory Factor 7 (IRF7) with Latent Membrane Protein 1 (LMP1) of Epstein-Barr Virus

Kim IW, Park HS

Interferon regulatory factor 7 (IRF7) is one of the transcriptional factors for the activation of type I Interferon (IFN) genes. It is known that IRF7 and the latent membrane protein...
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Biochemical Characteristics of a Korean Patient with Mucolipidosis III (Pseudo-Hurler Polydystrophy)

Song J, Lee DS, Cho HI, Kim JQ, Cho TJ

We performed a biochemical study on the patient with mucolipidosis III (ML-III, pseudo-Hurler polydystrophy) in Korea. Confluent fibroblasts from the patient and from normal controls were cultured for 4, 12,...
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Localization of actin and myosin in Cryptosporidium parvum using immunogold staining

Yu JR, Chai JY

The location of actin and myosin of the several stages of Cryptosporidium parvum was observed. The tissue antigen of C. parvum was prepared through immunosuppression of ICR mice with Depomedrol....
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Molecular Motor Proteins of the Kinesin Superfamily Proteins (KIFs): Structure, Cargo and Disease

Seog DH, Lee DH, Lee SK

Intracellular organelle transport is essential for morphogenesis and functioning of the cell. Kinesins and kinesin-related proteins make up a large superfamily of molecular motors that transport cargoes such as vesicles,...
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Angiotensin II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase

Ha TS, Park HY, Seong SB, Ahn HY

Angiotensin II (Ang II) induces the pathological process of vascular structures, including renal glomeruli by hemodynamic and nonhemodynamic direct effects. In kidneys, Ang II plays an important role in the...
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The Role of Foxo3 in Leydig Cells

Choi YS, Song JE, Kong BS, Hong JW, Novelli S, Lee EJ

PURPOSE: Foxo3 in female reproduction has been reported to regulate proliferation of granulose cells that form follicles. There are no reports so far that discuss on the role of Foxo3...
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Expression of Beta-catenin and E-cadherin in Early Gastric Cancer: Correlation with Clinicopathologic Parameters

Song BJ, Park YJ, Kim HS, Kim CN, Chang SH

  • KMID: 772610
  • Korean J Gastroenterol.
  • 2004 Feb;43(2):82-89.
BACKGROUND/AIMS: Beta-catenin is known to perform two unrelated functions in cadherin-mediated cell to cell adhesion system and Wnt pathway. Recent studies reported cytoplasmic and nuclear accumulation of beta-catenin by...
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Polycystin-1 Expression in Fetal, Adult and Autosomal Dominant Polycystic Kidney

Chae SW, Cho EY, Park MS, Lee KB, Kim H, Kim U

The mutation of the PKD1 gene causes autosomal dominant polycystic kidney disease (ADPKD), and the PKD1 gene encodes polycystin-1 (PC-1). PC-1 is thought to be a cell-cell/matrix adhesion receptor molecule...
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Endoplasmic reticulum retention and degradation of T cell antigen receptor beta chain

Lee SJ

  • KMID: 1109299
  • Exp Mol Med.
  • 1998 Sep;30(3):159-164.
The T cell antigen receptor-CD3 (TCR/CD3) complex is assembled in the endoplasmic reticulum (ER) of T cells after synthesis of individual chains, and is transported to the cell surface for immune recognition...
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Na+-Ca2+ exchanger modulates Ca2+ content in intracellular Ca2+ stores in rat osteoblasts

Jung SY, Park YJ, Park YJ, Cha SH, Lee MZ, Suh CK

  • KMID: 756068
  • Exp Mol Med.
  • 2007 Aug;39(4):458-468.
Na+ -Ca2+ exchanger (NCX) transports Ca2+ coupled with Na+ across the plasma membrane in a bi-directional mode. Ca2+ flux via NCX mediates osteogenic processes, such as formation of extracellular matrix...
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Expression of Inducible Nitric Oxide Synthase Is Increased in Rat Barrett's Esophagus Induced by Duodenal Contents Reflux

Bae JD, Jung KH, Ahn WS, Bae SH, Jang TJ

Barrett's esophagus is a premalignant condition of esophageal adenocarcinoma. Inducible nitric oxide synthase (iNOS) is induced by cytokines and can generate locally high concentrations of nitric oxide (NO), whose metabolites...
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Ethyl Pyruvate Has Anti-Inflammatory and Delayed Myocardial Protective Effects after Regional Ischemia/Reperfusion Injury

Jang IS, Park MY, Shin IW, Sohn JT, Lee HK, Chung YK

PURPOSE: Ethyl pyruvate has anti-inflammatory properties and protects organs from ischemia/reperfusion (I/R)-induced tissue injury. The aim of this study was to determine whether ethyl pyruvate decreases the inflammatory response after...
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Reactive Astrocytes Expressing Intense Estrogen Receptor-alpha Immunoreactivities Have Much Elongated Cytoplasmic Processes: An Autopsy Case of Human Cerebellar Tissue with Multiple Genitourinary and Gastrointestinal Anomalies

Kim EJ, Oh CS, Kim J, Kim WH, Chung YH, Shin DH

We performed an immunohistochemical study on the estrogen receptor alpha (ER-alpha) distribution in the cerebellum of a human neonate with multiple congenital anomalies, that had been acquired during autopsy. Although...
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Recurrent Mesectodermal Leiomyoma of the Ciliary Body: A Case Report

Park SH, Lee JH, Chae YS, Kim CH

A 19-yr-old woman with a previous history of a mass of the right ciliary body presented with a decreased visual acuity of right eye. Clinicoradiologic examinations suggested a recurrent mass...
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RET/PTC and CK19 Expression in Papillary Thyroid Carcinoma and Its Clinicopathologic Correlation

Shin E, Chung WY, Yang WI, Park CS, Hong SW

Recently, the rearrangement of RET proto-oncogene has been reported to be the most common genetic change in papillary thyroid carcinoma (PTC). However, its prevalence has been reported variably and its relation...
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NF-kappaB Binding Activity and Cyclooxygenase-2 Expression in Persistent betaCCI(4)-Treated Rat Liver Injury

Kim SH, Chu HJ, Kang DH, Song GA, Cho M, Yang US, Kim HJ, Chung HY

The involvement of NF-kappaB binding activity is known to be important in the mechanism of acute liver injury and in the induction of cyclooxygenase (COX-2). This study was performed to...
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Heat shock protein 70 alters the endosome-lysosomal localization of huntingtin

Kang BS, Ahn JY, Kim MK, Kim HJ, Kang L, Lim HC, Park KS, Lee JS, Seo JS, Cha CI, Kim SU, Park YJ, Kim M

  • KMID: 1103679
  • Exp Mol Med.
  • 2007 Feb;39(1):38-46.
Huntington's disease is caused by CAG trinucleotide expansions in the gene encoding huntingtin. N- terminal fragments of huntingtin with polyglutamine produce aggregates in the endosome-lysosomal system, where proteolytic fragments of...
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Congenital Neuroblastoma with Multiple Metastases: A Case Report

Sul HJ, Kang DY

Neuroblastomas are derived from the neural crest ectoderm, and are the most common solid abdominal masses of infancy. Congenital neuroblastoma, however, is rare. We report a rare case of congenital...
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Prognostic Effect of cytoplasmic CD79a Expression in Acute Myeloid Leukemia with t(8;21)

Chung HJ, Chi HS, Cho YU, Lee EH, Jang S, Park CJ, Seo EJ

BACKGROUND: Although cytoplasmic CD79a (cytCD79a) is a highly lineage-specific marker of B lymphoid cells and plays an important role in the diagnosis of acute leukemia, its clinical significance is...
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