J Korean Med Sci.  2003 Aug;18(4):618-620. 10.3346/jkms.2003.18.4.618.

Congenital Neuroblastoma with Multiple Metastases: A Case Report

• Sul HJ
• Kang DY

• KMID: 648922
• DOI: http://doi.org/10.3346/jkms.2003.18.4.618

Abstract

Neuroblastomas are derived from the neural crest ectoderm, and are the most common solid abdominal masses of infancy. Congenital neuroblastoma, however, is rare. We report a rare case of congenital neuroblastoma with multiple metastases found at autopsy, performed at 2 days after birth. He was born by cesarian section and weighed 2,350 g. His respiration was weak and abdomen was distended. The patient died 2 days after birth. Postmortem examination revealed a relatively well demarcated ovoid mass, in the left adrenal, with necrosis and hemorrhage. Multiple small metastatic tumor nodules in the liver, lung, kidney, brain, rib, thyroid glands, and spleen, were noted. The histopathological pictures confirmed the diagnosis of neuroblastoma of the adrenal with multiple metastasis.

Keyword

Neuroblastoma; Congenital; Neoplasm Metastases; Adrenal Gland Neoplasms

MeSH Terms

Adrenal Gland Neoplasms/congenital/*diagnosis/pathology
Autopsy
Chromogranins/biosynthesis
Cytoplasm/metabolism
Human
Immunohistochemistry
Infant, Newborn
Male
Necrosis
Neoplasm Metastasis
Neuroblastoma/congenital/*diagnosis/pathology
Phosphopyruvate Hydratase/biosynthesis