- The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1)
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Kim M, Kim TH, Lee HH
- KMID: 2200913
- J Menopausal Med.
- 2016 Apr;22(1):6-8.
- doi: 10.6118/jmm.2016.22.1.6
The Jun activation-domain binding protein 1 (Jab1) recognize a potential coactivator of activator protein 1 (AP-1) such as c-fos, c-jun transcription factor and the fifth subunit of the COP9 signalosome... -
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- Expression of p27 Protein in Adenoma and Adenocarcinoma of the Colorectum
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Son HJ, Kang MJ
- KMID: 2334251
- J Korean Soc Coloproctol.
- 2001 Oct;17(5):251-258.
PURPOSE: The cyclin-dependent kinase inhibitor p27kip1 protein is a negative regulator of the cell division cycle, and its degradation is required for entry into the S phase. Loss of p27(kip1)... -
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- Expression of Cyclin Dependent Kinase Inhibitors of KIP Family in Gastric Cancer
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Lee SJ, Joo YE, Kim HS, Choi SK, Rew JS, Park CS, Kim SJ
- KMID: 1113428
- Korean J Gastroenterol.
- 2005 Aug;46(2):84-93.
BACKGROUND/AIMS: The cyclin-dependent kinase inhibitors (CDKI) including p21, p27, and p57 of the kinase inhibitor protein (KIP) family are negative regulators of cell cycle progression and potentially act as... -
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- MicroRNA-186 targets SKP2 to induce p27(Kip1)-mediated pituitary tumor cell cycle deregulation and modulate cell proliferation
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He Z, Chen L, Wang Q, Yin C, Hu J, Hu X, Fei F, Tang J
- KMID: 2443605
- Korean J Physiol Pharmacol.
- 2019 May;23(3):171-179.
- doi: 10.4196/kjpp.2019.23.3.171
Pituitary tumors are usually benign but can occasionally exhibit hormonal and proliferative behaviors. Dysregulation of the G1/S restriction point largely contributes to the over-proliferation of pituitary tumor cells. F-box protein... -
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- Subcellular Localization of p27(kip1) in Breast Cancer and Its Prognostic Significance
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Hong SH, Kim DC, Cho SH, Hong YS
- KMID: 2277665
- Korean J Pathol.
- 2006 Jun;40(3):185-192.
BACKGROUND: p27 is a member of the cyclin-dependent kinase (CDK) inhibitors that arrest the progression of the cell cycle; thus, it acts as a tumor suppressor gene. The loss or... -
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- Expression of p27kip1 and Cyclin D1 in Serous Epithelial Ovarian Tumors
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Kwon SY, Chang ES, Kwon KY, Park KK, Kim SK
- KMID: 2275607
- Korean J Pathol.
- 2001 Jun;35(3):220-225.
BACKGROUND: p27kip1 is a member of the Cip/Kip family of the cyclin-dependent kinase inhibitors and is a potential tumor suppressor gene. Decreased expression of p27kip1 is associated with high histologic... -
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- Significance of the Expression of Cyclin-Dependent Kinase Inhibitor, p27Kip1, in Human Breast Cancer
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Song SY, Kim DH, Suh YL, Ko YH, Kim DS, Nam SJ, Yang JH
- KMID: 2275703
- Korean J Pathol.
- 1998 Dec;32(12):1081-1088.
p27Kip1 protein, a negative cell cycle regulator in G1 progression, has been reported to be related with human cancers including colon, breast and non-small cell lung carcinomas. To elucidate a... -
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- Aberrant Cell Cycle Regulation in Cervical Carcinoma
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Kim YT, Zhao M
- KMID: 2158138
- Yonsei Med J.
- 2005 Oct;46(5):597-613.
- doi: 10.3349/ymj.2005.46.5.597
Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However,... -
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- p27 Loss Is Associated with Poor Prognosis in Gastroenteropancreatic Neuroendocrine Tumors
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Kim HS, Lee HS, Nam KH, Choi J, Kim WH
- KMID: 2380376
- Cancer Res Treat.
- 2014 Oct;46(4):383-392.
- doi: 10.4143/crt.2013.102
PURPOSE: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogeneous disease group originating from the neuroendocrine cells. Identification of prognostic markers, related to neuroendocrine tissue-selective tumorigenesis, is necessary to find therapeutic targets. MATERIALS... -
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- Expression of p27Kip1 Protein in Carcinoma of the Urinary Bladder
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Kim KK, Kim JR
- KMID: 2275655
- Korean J Pathol.
- 2000 May;34(5):341-348.
The cyclin-dependent kinase (cdk) inhibitor p27Kip1 gene is a powerful molecular determinant of cell cycle progression. Loss of expression of p27Kip1 has recently been shown to be predictive of disease... -
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- Expression of Cell Cycle Related Genes in HL60 Cells Undergoing Apoptosis by X-irradiation
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Kim JH, Park IK
- KMID: 2323691
- J Korean Soc Ther Radiol Oncol.
- 1998 Dec;16(4):377-388.
PURPOSE: To evaluate changes in expression of cell cycle related genes during apoptosis induced in HL60 cells by X-irradiation to understand molecular biologic aspects in mechanism of radiation therapy. MATERIAL... -
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- Expression of p27Kip1 Protein Associated with Poor Clinical Outcome in Human Gastric Cancer
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Bu DS, Han SH, Bae BN, Kim KH, Kim HJ, Kim YD, Kim HY, Park KM
- KMID: 1895841
- J Korean Surg Soc.
- 2001 Aug;61(2):153-157.
PURPOSE: p27Kip1 protein is an inhibitor of cyclin-dependent kinases and is thought to be a potential prognostic indicator for numerous human cancers. We investigated the expression of p27Kip1 in gastric... -
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- Expression of p27kip1 Protein in Astrocytic Tumors
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Kim DY, Son HJ, Chung MJ, Kang MJ
- KMID: 1955975
- J Korean Neurosurg Soc.
- 2001 Apr;30(4):443-450.
OBJECTIVE: The cyclin-dependent kinase inhibitor p27kip1 protein is a negative regulator of the cell cycle, and its degradation is required for entry into the S phase. Loss of p27kip1... -
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- Expression of p27Kip1 Protein in Colorectal Adenocarcinoma
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Lee HI, Kim DH, Nam ES, Park HR, Chae SW, Park CJ, Kim JR, Shin HS
- KMID: 1725654
- Korean J Pathol.
- 2000 Feb;34(2):132-137.
p27Kip1 has been recognized as a negative regulator of cell cycle. Reduced level of p27 expression is associated with development and aggressiveness of several human tumors. To investigate the role... -
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- Expression of Proteins Related Cell Cycle and Apoptosis during Diethylnitrosamine (DEN)-induced Hepatocarcinogenesis in Rats
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Sim WJ, Kim YS, Choi YS, Kim BG, Cha SJ, Lim HM, Park ES
- KMID: 1476240
- J Korean Surg Soc.
- 2008 Dec;75(6):359-367.
PURPOSE: To explore the role of cell cycle and apoptosis regulators during hepatocarcinogenesis, the expression of cell cycle-related proteins (cyclin D1 and p27kip1) and apoptosis-related proteins (p53, survivin, caspase 3). METHODS:... -
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- The Mechanisms of Growth Inhibition by Transforming Growth Factor-beta1 in Cervical Carcinoma Cell Lines
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Kim MR, Kim JW, Han GT, Lee JM, Jung JK, Namkoong S, Kim SJ, Lee HY, Kim SP
- KMID: 2260917
- Korean J Obstet Gynecol.
- 1998 Apr;41(4):1061-1069.
Transforming growth factor- 1 (TGF- 1) is known to be a potent growth inhibitor of many cell types including most epithelial cells. However, the molecular mechanism of TGF- 1 action... -
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- Expression of p27Kip1 Protein and Correlation with Clinicopathologic Factors in Colorectal Carcinoma
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Hong BK, Kim HJ, Lee TJ, Park YG, Ji GC, Chang IT, Park SI, Lee JH
- KMID: 2145216
- J Korean Surg Soc.
- 2001 May;60(5):536-541.
PURPOSE: The p27Kip1 gene has been recognized as a negative regulator of the cell cycle and a potential tumor suppressor gene. Reduced expression of the p27Kip1 protein has been reported... -
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- Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma
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Chen L, Yuan D, Wang GL, Wang Y, Wu YY, Zhu J
- KMID: 2157846
- J Korean Med Sci.
- 2010 Oct;25(10):1438-1442.
- doi: 10.3346/jkms.2010.25.10.1438
The aim of this study was to investigate the expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma (HCC) and their clinicopathological significance. The expression of Tspan-1, Jab1 and... -
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- Do Helper T Cell Subtypes in Lymphocytic Thyroiditis Play a Role in the Antitumor Effect?
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Yang SW, Kang SH, Kim KR, Choi IH, Chang HS, Oh YL, Hong SW
- KMID: 2353600
- J Pathol Transl Med.
- 2016 Sep;50(5):377-384.
- doi: 10.4132/jptm.2016.07.25
BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently accompanied by lymphocytic thyroiditis (LT). Some reports claim that Hashimoto's thyroiditis (the clinical form of LT) enhances the likelihood of PTC; however, others... -
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- Growth Inhibition of Hepatocellular Carcinoma Huh7 Cells by Lactobacillus casei Extract
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Han DJ, Kim JB, Park SY, Yang MG, Kim H
- KMID: 1793166
- Yonsei Med J.
- 2013 Sep;54(5):1186-1193.
- doi: 10.3349/ymj.2013.54.5.1186
PURPOSE: Lactobacillus casei (L. casei) is known to exert anti-proliferation effects on many types of cancer cells. However, the effect of L. casei on liver cancer has not been reported.... -
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