J Korean Surg Soc.  2001 Aug;61(2):153-157.

Expression of p27Kip1 Protein Associated with Poor Clinical Outcome in Human Gastric Cancer

• Bu DS
• Han SH
• Bae BN
• Kim KH
• Kim HJ
• Kim YD
• Kim HY
• Park KM

Abstract

PURPOSE: p27Kip1 protein is an inhibitor of cyclin-dependent kinases and is thought to be a potential prognostic indicator for numerous human cancers. We investigated the expression of p27Kip1 in gastric cancer in order to estimate its clinical utility.
METHODS
Immunohistochemical assay for p27Kip1 protein was performed in 64 patients with primary gastric cancer. The correlation between p27Kip1 and clinical-biological parameters including patient survival was analyzed.
RESULTS
p27Kip1 expression was suppressed in 40 (62.5%) of 64 gastric cancer patients. Expression of p27Kip1 was significantly reduced in poorly differentiated cancers (82.1%, 23/28; P=0.015) and was also reduced in tumors with a high S-phase fraction as compared with tumors showing a low S-phase fraction (86.7%, 26/30, 41.2%, 14/34; P=0.0002). In univariate analysis, the extent of the disease (P<0.001), and reduced expression of p27Kip1 (P=0.0006) were statistically significant to predict the patient's outcome, however depth of invasion (P=0.008) and pathologic stage (P=0.009) emerged as significant prognostic indicators in the multivariate analysis.
CONCLUSION
The expression of p27Kip1 is closely linked with cell proliferation and differentiation of human gastric cancer. p27Kip1 appears to have potential as a prognostic marker in the management of gastric cancer patients.

Keyword

Cell proliferation; Immunohistochemistry; Prognosis; Gastric cancer; p27Kip1

MeSH Terms

Cell Proliferation
Cyclin-Dependent Kinase Inhibitor p27*
Cyclin-Dependent Kinases
Humans*
Immunohistochemistry
Multivariate Analysis
Prognosis
Stomach Neoplasms*
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases