J Korean Med Sci.  1999 Oct;14(5):526-530. 10.3346/jkms.1999.14.5.526.

c-Myc expression is related with cell proliferation and associated with poor clinical outcome in human gastric cancer

• Han S
• Kim HY
• Park K
• Cho HJ
• Lee MS
• Kim HJ
• Kim YD

• KMID: 646020
• DOI: http://doi.org/10.3346/jkms.1999.14.5.526

Abstract

We underwent protein assay for Myc expression in 76 human gastric cancer tissues using immunohistochemistry. Expression of Myc protein was analyzed according to proliferative indices measured by flow cytometry. Levels of Myc protein expression was evaluated by correlating with biologic and clinical parameters. In 36 (47.4%) of 76 primary gastric cancers, overexpression of Myc was observed. We could observe expression of Myc protein in a significant portion of early gastric cancer (42.9%). Expression of Myc protein was demonstrated to be more frequent in poorly differentiated cancer cells (p=0.043). However, expression of Myc protein had little influence over progress or extent of the disease. Expression of Myc protein was significantly correlated with increased proliferative activity (p=0.032) and patients with high levels of Myc expression had poor disease-free survival. In a certain proportion of human gastric cancer, Myc protein may function as a regulator of cancer cell growth and expression of Myc may represent an aggressive phenotype of gastric cancer.

Keyword

Cell division; Stomach neoplasms; Immunohistochemistry; Proto-oncogene proteins, myc; Prognosis; Survival

MeSH Terms

Adult
Aged
Cell Division
Female
Flow Cytometry
Human
Immunohistochemistry
Lymphatic Metastasis
Male
Middle Age
Neoplasm Invasiveness
Neoplasm Staging
Proto-Oncogene Proteins c-myc/analysis*
Stomach/pathology
Stomach/chemistry
Stomach Neoplasms/pathology
Stomach Neoplasms/mortality
Stomach Neoplasms/chemistry*
Survival Rate